Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts
Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze...
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creator | López-Montemayor, Paloma Zavala, Judith Montalvo-Parra, María Dolores Guerrero-Ramírez, Guillermo Isaac Mayolo-Deloisa, Karla Enriquez-Ochoa, Daniela Martínez-García, Bernardo Loya-García, Denise Guerrero-Martínez, Alba Miriam Valdez-García, Jorge Eugenio |
description | Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250 μg/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24 h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased (P |
doi_str_mv | 10.1155/2021/5814221 |
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Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250 μg/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24 h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased (P<0.01) in HPF treated with 250 μg/mL of S. dendroideum when compared with untreated HPF. The total phenolic concentration in the S. dendroideum lyophilized was 33.67 mg gallic acid equivalents (GAE)/g. Antioxidant activity was 384.49 mM Trolox equivalents/mL. The main phenolic compounds identified by HPLC analysis were the kaempferol-3-O-glycoside, kaempferol-3-O-rhamnoside, kaempferol-3-O-neohesperidoside-7-O-α-rhamnopyranoside, and kaempferol-3-O-glycoside-7-O-rhamnoside. Conclusions. S. dendroideum decreases the proliferation of HPF and the expression of VEGF and CTGF. The phenolic compound concentration, antioxidant activity, and phytochemical profile may play a role in these effects.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/5814221</identifier><identifier>PMID: 34707671</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Acids ; Antioxidants ; Cell viability ; Connective tissue growth factor ; Enzymes ; Evidence-based medicine ; Fibroblasts ; Gallic acid ; Gene expression ; High-performance liquid chromatography ; Kaempferol ; Keratin ; Phenolic compounds ; Polyphenols ; Reagents ; Sedum dendroideum ; Vascular endothelial growth factor ; Vitamin E</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021, p.5814221-7</ispartof><rights>Copyright © 2021 Paloma López-Montemayor et al.</rights><rights>Copyright © 2021 Paloma López-Montemayor et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Paloma López-Montemayor et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c405t-1b4a7f0e3c90f6c948783759ac513526fc373c06db1bfef5adc0c1a61067b153</cites><orcidid>0000-0001-8454-1602 ; 0000-0002-4789-5134 ; 0000-0001-9144-6574 ; 0000-0002-6116-5816 ; 0000-0002-9985-5716 ; 0000-0001-5778-6591 ; 0000-0003-4415-7301 ; 0000-0001-8828-720X ; 0000-0002-2826-2518</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545536/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8545536/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34707671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Santin, José Roberto</contributor><contributor>José Roberto Santin</contributor><creatorcontrib>López-Montemayor, Paloma</creatorcontrib><creatorcontrib>Zavala, Judith</creatorcontrib><creatorcontrib>Montalvo-Parra, María Dolores</creatorcontrib><creatorcontrib>Guerrero-Ramírez, Guillermo Isaac</creatorcontrib><creatorcontrib>Mayolo-Deloisa, Karla</creatorcontrib><creatorcontrib>Enriquez-Ochoa, Daniela</creatorcontrib><creatorcontrib>Martínez-García, Bernardo</creatorcontrib><creatorcontrib>Loya-García, Denise</creatorcontrib><creatorcontrib>Guerrero-Martínez, Alba Miriam</creatorcontrib><creatorcontrib>Valdez-García, Jorge Eugenio</creatorcontrib><title>Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250 μg/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24 h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased (P<0.01) in HPF treated with 250 μg/mL of S. dendroideum when compared with untreated HPF. The total phenolic concentration in the S. dendroideum lyophilized was 33.67 mg gallic acid equivalents (GAE)/g. Antioxidant activity was 384.49 mM Trolox equivalents/mL. The main phenolic compounds identified by HPLC analysis were the kaempferol-3-O-glycoside, kaempferol-3-O-rhamnoside, kaempferol-3-O-neohesperidoside-7-O-α-rhamnopyranoside, and kaempferol-3-O-glycoside-7-O-rhamnoside. Conclusions. S. dendroideum decreases the proliferation of HPF and the expression of VEGF and CTGF. The phenolic compound concentration, antioxidant activity, and phytochemical profile may play a role in these effects.</description><subject>Acids</subject><subject>Antioxidants</subject><subject>Cell viability</subject><subject>Connective tissue growth factor</subject><subject>Enzymes</subject><subject>Evidence-based medicine</subject><subject>Fibroblasts</subject><subject>Gallic acid</subject><subject>Gene expression</subject><subject>High-performance liquid chromatography</subject><subject>Kaempferol</subject><subject>Keratin</subject><subject>Phenolic compounds</subject><subject>Polyphenols</subject><subject>Reagents</subject><subject>Sedum dendroideum</subject><subject>Vascular endothelial growth factor</subject><subject>Vitamin 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chromatography</topic><topic>Kaempferol</topic><topic>Keratin</topic><topic>Phenolic compounds</topic><topic>Polyphenols</topic><topic>Reagents</topic><topic>Sedum dendroideum</topic><topic>Vascular endothelial growth factor</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>López-Montemayor, Paloma</creatorcontrib><creatorcontrib>Zavala, Judith</creatorcontrib><creatorcontrib>Montalvo-Parra, María Dolores</creatorcontrib><creatorcontrib>Guerrero-Ramírez, Guillermo Isaac</creatorcontrib><creatorcontrib>Mayolo-Deloisa, Karla</creatorcontrib><creatorcontrib>Enriquez-Ochoa, Daniela</creatorcontrib><creatorcontrib>Martínez-García, Bernardo</creatorcontrib><creatorcontrib>Loya-García, Denise</creatorcontrib><creatorcontrib>Guerrero-Martínez, Alba Miriam</creatorcontrib><creatorcontrib>Valdez-García, Jorge Eugenio</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription 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Santin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>5814221</spage><epage>7</epage><pages>5814221-7</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250 μg/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24 h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased (P<0.01) in HPF treated with 250 μg/mL of S. dendroideum when compared with untreated HPF. The total phenolic concentration in the S. dendroideum lyophilized was 33.67 mg gallic acid equivalents (GAE)/g. Antioxidant activity was 384.49 mM Trolox equivalents/mL. The main phenolic compounds identified by HPLC analysis were the kaempferol-3-O-glycoside, kaempferol-3-O-rhamnoside, kaempferol-3-O-neohesperidoside-7-O-α-rhamnopyranoside, and kaempferol-3-O-glycoside-7-O-rhamnoside. Conclusions. S. dendroideum decreases the proliferation of HPF and the expression of VEGF and CTGF. The phenolic compound concentration, antioxidant activity, and phytochemical profile may play a role in these effects.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34707671</pmid><doi>10.1155/2021/5814221</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8454-1602</orcidid><orcidid>https://orcid.org/0000-0002-4789-5134</orcidid><orcidid>https://orcid.org/0000-0001-9144-6574</orcidid><orcidid>https://orcid.org/0000-0002-6116-5816</orcidid><orcidid>https://orcid.org/0000-0002-9985-5716</orcidid><orcidid>https://orcid.org/0000-0001-5778-6591</orcidid><orcidid>https://orcid.org/0000-0003-4415-7301</orcidid><orcidid>https://orcid.org/0000-0001-8828-720X</orcidid><orcidid>https://orcid.org/0000-0002-2826-2518</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acids Antioxidants Cell viability Connective tissue growth factor Enzymes Evidence-based medicine Fibroblasts Gallic acid Gene expression High-performance liquid chromatography Kaempferol Keratin Phenolic compounds Polyphenols Reagents Sedum dendroideum Vascular endothelial growth factor Vitamin E |
title | Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts |
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