Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature communications 2015-04, Vol.6 (1), p.6416-6416, Article 6416
Hauptverfasser: Nussbaum, Claudia, Bannenberg, Sarah, Keul, Petra, Gräler, Markus H., Gonçalves-de-Albuquerque, Cassiano F., Korhonen, Hanna, von Wnuck Lipinski, Karin, Heusch, Gerd, de Castro Faria Neto, Hugo C., Rohwedder, Ina, Göthert, Joachim R., Prasad, Vysakh Pushpa, Haufe, Günter, Lange-Sperandio, Baerbel, Offermanns, Stefan, Sperandio, Markus, Levkau, Bodo
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 6416
container_issue 1
container_start_page 6416
container_title Nature communications
container_volume 6
creator Nussbaum, Claudia
Bannenberg, Sarah
Keul, Petra
Gräler, Markus H.
Gonçalves-de-Albuquerque, Cassiano F.
Korhonen, Hanna
von Wnuck Lipinski, Karin
Heusch, Gerd
de Castro Faria Neto, Hugo C.
Rohwedder, Ina
Göthert, Joachim R.
Prasad, Vysakh Pushpa
Haufe, Günter
Lange-Sperandio, Baerbel
Offermanns, Stefan
Sperandio, Markus
Levkau, Bodo
description Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P 3 ) and Gα q , PLCβ and Ca 2+ . Intra-arterial S1P administration increases leukocyte rolling, while S1P 3 deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P 3 . Histamine and epinephrine require S1P 3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P 1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P 1 −/− mice. In agreement with a dominant pro-rolling effect of S1P 3 , FTY720 inhibits rolling in control and S1P 1 −/− but not in S1P 3 −/− mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action. The lipid sphingosine-1-phosphate (S1P) is known to mediate leukocyte recruitment in inflammation. Here, Nussbaum et al. show that S1P, via its receptor S1P3, also regulates leukocyte rolling on endothelium by promoting the presentation of the adhesion molecule P-selectin on the endothelial surface.
doi_str_mv 10.1038/ncomms7416
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4396399</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3642795471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-5f3a87fb54dc917029eec5842174e677327ae02337885a82016475c974918c893</originalsourceid><addsrcrecordid>eNplkV1LHDEYhUOxVFFv-gPKQG9KZTRfM8ncCCJ-gVCh7XXIZN_dic0kYzJTWH-9GVbtWnOThPPk5LwchD4TfEwwkyfehL5PgpP6A9qjmJOSCMp2ts676DCle5wXa4jk_BPapZVkVDC8h9qfQ2f9KiTroSTl0IU0dHqEIoKBYQyxYMUQQx9GSIWD6U8w61kNzuVnRbsu-tBaZx_nG_hFGDtwVrvirkzgwIzWH6CPS-0SHD7v--j35cWv8-vy9sfVzfnZbWkqLMeyWjItxbKt-MI0RGDaAJhKckoEh1qIHFgDpowJKSstKSY1F5VpBM9TGdmwfXS68R2mtoeFAT9G7dQQba_jWgVt1VvF206twl_FWVOzZjb49mwQw8MEaVS9TQac0x7ClBSp60ZyjKs6o1__Q-_DFH0eb6Yk5ZQSkqnvG8rEkFKE5WsYgtXcnvrXXoa_bMd_RV-6ysDRBkhZ8iuIW3--t3sCbgWlYw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1668242211</pqid></control><display><type>article</type><title>Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin</title><source>MEDLINE</source><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Springer Nature OA Free Journals</source><creator>Nussbaum, Claudia ; Bannenberg, Sarah ; Keul, Petra ; Gräler, Markus H. ; Gonçalves-de-Albuquerque, Cassiano F. ; Korhonen, Hanna ; von Wnuck Lipinski, Karin ; Heusch, Gerd ; de Castro Faria Neto, Hugo C. ; Rohwedder, Ina ; Göthert, Joachim R. ; Prasad, Vysakh Pushpa ; Haufe, Günter ; Lange-Sperandio, Baerbel ; Offermanns, Stefan ; Sperandio, Markus ; Levkau, Bodo</creator><creatorcontrib>Nussbaum, Claudia ; Bannenberg, Sarah ; Keul, Petra ; Gräler, Markus H. ; Gonçalves-de-Albuquerque, Cassiano F. ; Korhonen, Hanna ; von Wnuck Lipinski, Karin ; Heusch, Gerd ; de Castro Faria Neto, Hugo C. ; Rohwedder, Ina ; Göthert, Joachim R. ; Prasad, Vysakh Pushpa ; Haufe, Günter ; Lange-Sperandio, Baerbel ; Offermanns, Stefan ; Sperandio, Markus ; Levkau, Bodo</creatorcontrib><description>Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P 3 ) and Gα q , PLCβ and Ca 2+ . Intra-arterial S1P administration increases leukocyte rolling, while S1P 3 deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P 3 . Histamine and epinephrine require S1P 3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P 1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P 1 −/− mice. In agreement with a dominant pro-rolling effect of S1P 3 , FTY720 inhibits rolling in control and S1P 1 −/− but not in S1P 3 −/− mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action. The lipid sphingosine-1-phosphate (S1P) is known to mediate leukocyte recruitment in inflammation. Here, Nussbaum et al. show that S1P, via its receptor S1P3, also regulates leukocyte rolling on endothelium by promoting the presentation of the adhesion molecule P-selectin on the endothelial surface.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms7416</identifier><identifier>PMID: 25832730</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/31 ; 13/51 ; 13/95 ; 14/1 ; 14/63 ; 631/250/249/2510/2100 ; 631/45/287/1196 ; 631/80/79 ; 64/110 ; 64/60 ; 692/698/1543/1565/1597 ; Animals ; Calcium - metabolism ; Endothelium, Vascular - metabolism ; Epinephrine - metabolism ; GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism ; Histamine - metabolism ; Human Umbilical Vein Endothelial Cells ; Humanities and Social Sciences ; Humans ; Immunohistochemistry ; Leukocyte Rolling - genetics ; Lysophospholipids - metabolism ; Male ; Mast Cells - metabolism ; Mice ; Mice, Knockout ; multidisciplinary ; Muscle, Skeletal - blood supply ; P-Selectin - metabolism ; Phospholipase C beta - metabolism ; Phosphotransferases (Alcohol Group Acceptor) - metabolism ; Receptors, Lysosphingolipid - genetics ; Receptors, Lysosphingolipid - metabolism ; Science ; Science (multidisciplinary) ; Sphingosine - analogs &amp; derivatives ; Sphingosine - metabolism ; Venules</subject><ispartof>Nature communications, 2015-04, Vol.6 (1), p.6416-6416, Article 6416</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Apr 2015</rights><rights>Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-5f3a87fb54dc917029eec5842174e677327ae02337885a82016475c974918c893</citedby><cites>FETCH-LOGICAL-c508t-5f3a87fb54dc917029eec5842174e677327ae02337885a82016475c974918c893</cites><orcidid>0000-0002-7689-3613 ; 0000000276893613</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396399/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396399/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25832730$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nussbaum, Claudia</creatorcontrib><creatorcontrib>Bannenberg, Sarah</creatorcontrib><creatorcontrib>Keul, Petra</creatorcontrib><creatorcontrib>Gräler, Markus H.</creatorcontrib><creatorcontrib>Gonçalves-de-Albuquerque, Cassiano F.</creatorcontrib><creatorcontrib>Korhonen, Hanna</creatorcontrib><creatorcontrib>von Wnuck Lipinski, Karin</creatorcontrib><creatorcontrib>Heusch, Gerd</creatorcontrib><creatorcontrib>de Castro Faria Neto, Hugo C.</creatorcontrib><creatorcontrib>Rohwedder, Ina</creatorcontrib><creatorcontrib>Göthert, Joachim R.</creatorcontrib><creatorcontrib>Prasad, Vysakh Pushpa</creatorcontrib><creatorcontrib>Haufe, Günter</creatorcontrib><creatorcontrib>Lange-Sperandio, Baerbel</creatorcontrib><creatorcontrib>Offermanns, Stefan</creatorcontrib><creatorcontrib>Sperandio, Markus</creatorcontrib><creatorcontrib>Levkau, Bodo</creatorcontrib><title>Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P 3 ) and Gα q , PLCβ and Ca 2+ . Intra-arterial S1P administration increases leukocyte rolling, while S1P 3 deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P 3 . Histamine and epinephrine require S1P 3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P 1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P 1 −/− mice. In agreement with a dominant pro-rolling effect of S1P 3 , FTY720 inhibits rolling in control and S1P 1 −/− but not in S1P 3 −/− mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action. The lipid sphingosine-1-phosphate (S1P) is known to mediate leukocyte recruitment in inflammation. Here, Nussbaum et al. show that S1P, via its receptor S1P3, also regulates leukocyte rolling on endothelium by promoting the presentation of the adhesion molecule P-selectin on the endothelial surface.</description><subject>13/31</subject><subject>13/51</subject><subject>13/95</subject><subject>14/1</subject><subject>14/63</subject><subject>631/250/249/2510/2100</subject><subject>631/45/287/1196</subject><subject>631/80/79</subject><subject>64/110</subject><subject>64/60</subject><subject>692/698/1543/1565/1597</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Epinephrine - metabolism</subject><subject>GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism</subject><subject>Histamine - metabolism</subject><subject>Human Umbilical Vein Endothelial Cells</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leukocyte Rolling - genetics</subject><subject>Lysophospholipids - metabolism</subject><subject>Male</subject><subject>Mast Cells - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>multidisciplinary</subject><subject>Muscle, Skeletal - blood supply</subject><subject>P-Selectin - metabolism</subject><subject>Phospholipase C beta - metabolism</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - metabolism</subject><subject>Receptors, Lysosphingolipid - genetics</subject><subject>Receptors, Lysosphingolipid - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sphingosine - analogs &amp; derivatives</subject><subject>Sphingosine - metabolism</subject><subject>Venules</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkV1LHDEYhUOxVFFv-gPKQG9KZTRfM8ncCCJ-gVCh7XXIZN_dic0kYzJTWH-9GVbtWnOThPPk5LwchD4TfEwwkyfehL5PgpP6A9qjmJOSCMp2ts676DCle5wXa4jk_BPapZVkVDC8h9qfQ2f9KiTroSTl0IU0dHqEIoKBYQyxYMUQQx9GSIWD6U8w61kNzuVnRbsu-tBaZx_nG_hFGDtwVrvirkzgwIzWH6CPS-0SHD7v--j35cWv8-vy9sfVzfnZbWkqLMeyWjItxbKt-MI0RGDaAJhKckoEh1qIHFgDpowJKSstKSY1F5VpBM9TGdmwfXS68R2mtoeFAT9G7dQQba_jWgVt1VvF206twl_FWVOzZjb49mwQw8MEaVS9TQac0x7ClBSp60ZyjKs6o1__Q-_DFH0eb6Yk5ZQSkqnvG8rEkFKE5WsYgtXcnvrXXoa_bMd_RV-6ysDRBkhZ8iuIW3--t3sCbgWlYw</recordid><startdate>20150402</startdate><enddate>20150402</enddate><creator>Nussbaum, Claudia</creator><creator>Bannenberg, Sarah</creator><creator>Keul, Petra</creator><creator>Gräler, Markus H.</creator><creator>Gonçalves-de-Albuquerque, Cassiano F.</creator><creator>Korhonen, Hanna</creator><creator>von Wnuck Lipinski, Karin</creator><creator>Heusch, Gerd</creator><creator>de Castro Faria Neto, Hugo C.</creator><creator>Rohwedder, Ina</creator><creator>Göthert, Joachim R.</creator><creator>Prasad, Vysakh Pushpa</creator><creator>Haufe, Günter</creator><creator>Lange-Sperandio, Baerbel</creator><creator>Offermanns, Stefan</creator><creator>Sperandio, Markus</creator><creator>Levkau, Bodo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Pub. Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7689-3613</orcidid><orcidid>https://orcid.org/0000000276893613</orcidid></search><sort><creationdate>20150402</creationdate><title>Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin</title><author>Nussbaum, Claudia ; Bannenberg, Sarah ; Keul, Petra ; Gräler, Markus H. ; Gonçalves-de-Albuquerque, Cassiano F. ; Korhonen, Hanna ; von Wnuck Lipinski, Karin ; Heusch, Gerd ; de Castro Faria Neto, Hugo C. ; Rohwedder, Ina ; Göthert, Joachim R. ; Prasad, Vysakh Pushpa ; Haufe, Günter ; Lange-Sperandio, Baerbel ; Offermanns, Stefan ; Sperandio, Markus ; Levkau, Bodo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-5f3a87fb54dc917029eec5842174e677327ae02337885a82016475c974918c893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13/31</topic><topic>13/51</topic><topic>13/95</topic><topic>14/1</topic><topic>14/63</topic><topic>631/250/249/2510/2100</topic><topic>631/45/287/1196</topic><topic>631/80/79</topic><topic>64/110</topic><topic>64/60</topic><topic>692/698/1543/1565/1597</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Epinephrine - metabolism</topic><topic>GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism</topic><topic>Histamine - metabolism</topic><topic>Human Umbilical Vein Endothelial Cells</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leukocyte Rolling - genetics</topic><topic>Lysophospholipids - metabolism</topic><topic>Male</topic><topic>Mast Cells - metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>multidisciplinary</topic><topic>Muscle, Skeletal - blood supply</topic><topic>P-Selectin - metabolism</topic><topic>Phospholipase C beta - metabolism</topic><topic>Phosphotransferases (Alcohol Group Acceptor) - metabolism</topic><topic>Receptors, Lysosphingolipid - genetics</topic><topic>Receptors, Lysosphingolipid - metabolism</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sphingosine - analogs &amp; derivatives</topic><topic>Sphingosine - metabolism</topic><topic>Venules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nussbaum, Claudia</creatorcontrib><creatorcontrib>Bannenberg, Sarah</creatorcontrib><creatorcontrib>Keul, Petra</creatorcontrib><creatorcontrib>Gräler, Markus H.</creatorcontrib><creatorcontrib>Gonçalves-de-Albuquerque, Cassiano F.</creatorcontrib><creatorcontrib>Korhonen, Hanna</creatorcontrib><creatorcontrib>von Wnuck Lipinski, Karin</creatorcontrib><creatorcontrib>Heusch, Gerd</creatorcontrib><creatorcontrib>de Castro Faria Neto, Hugo C.</creatorcontrib><creatorcontrib>Rohwedder, Ina</creatorcontrib><creatorcontrib>Göthert, Joachim R.</creatorcontrib><creatorcontrib>Prasad, Vysakh Pushpa</creatorcontrib><creatorcontrib>Haufe, Günter</creatorcontrib><creatorcontrib>Lange-Sperandio, Baerbel</creatorcontrib><creatorcontrib>Offermanns, Stefan</creatorcontrib><creatorcontrib>Sperandio, Markus</creatorcontrib><creatorcontrib>Levkau, Bodo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied &amp; Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nussbaum, Claudia</au><au>Bannenberg, Sarah</au><au>Keul, Petra</au><au>Gräler, Markus H.</au><au>Gonçalves-de-Albuquerque, Cassiano F.</au><au>Korhonen, Hanna</au><au>von Wnuck Lipinski, Karin</au><au>Heusch, Gerd</au><au>de Castro Faria Neto, Hugo C.</au><au>Rohwedder, Ina</au><au>Göthert, Joachim R.</au><au>Prasad, Vysakh Pushpa</au><au>Haufe, Günter</au><au>Lange-Sperandio, Baerbel</au><au>Offermanns, Stefan</au><au>Sperandio, Markus</au><au>Levkau, Bodo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2015-04-02</date><risdate>2015</risdate><volume>6</volume><issue>1</issue><spage>6416</spage><epage>6416</epage><pages>6416-6416</pages><artnum>6416</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P 3 ) and Gα q , PLCβ and Ca 2+ . Intra-arterial S1P administration increases leukocyte rolling, while S1P 3 deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P 3 . Histamine and epinephrine require S1P 3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P 1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P 1 −/− mice. In agreement with a dominant pro-rolling effect of S1P 3 , FTY720 inhibits rolling in control and S1P 1 −/− but not in S1P 3 −/− mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action. The lipid sphingosine-1-phosphate (S1P) is known to mediate leukocyte recruitment in inflammation. Here, Nussbaum et al. show that S1P, via its receptor S1P3, also regulates leukocyte rolling on endothelium by promoting the presentation of the adhesion molecule P-selectin on the endothelial surface.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25832730</pmid><doi>10.1038/ncomms7416</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7689-3613</orcidid><orcidid>https://orcid.org/0000000276893613</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2041-1723
ispartof Nature communications, 2015-04, Vol.6 (1), p.6416-6416, Article 6416
issn 2041-1723
2041-1723
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4396399
source MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA Free Journals
subjects 13/31
13/51
13/95
14/1
14/63
631/250/249/2510/2100
631/45/287/1196
631/80/79
64/110
64/60
692/698/1543/1565/1597
Animals
Calcium - metabolism
Endothelium, Vascular - metabolism
Epinephrine - metabolism
GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism
Histamine - metabolism
Human Umbilical Vein Endothelial Cells
Humanities and Social Sciences
Humans
Immunohistochemistry
Leukocyte Rolling - genetics
Lysophospholipids - metabolism
Male
Mast Cells - metabolism
Mice
Mice, Knockout
multidisciplinary
Muscle, Skeletal - blood supply
P-Selectin - metabolism
Phospholipase C beta - metabolism
Phosphotransferases (Alcohol Group Acceptor) - metabolism
Receptors, Lysosphingolipid - genetics
Receptors, Lysosphingolipid - metabolism
Science
Science (multidisciplinary)
Sphingosine - analogs & derivatives
Sphingosine - metabolism
Venules
title Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T04%3A52%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sphingosine-1-phosphate%20receptor%203%20promotes%20leukocyte%20rolling%20by%20mobilizing%20endothelial%20P-selectin&rft.jtitle=Nature%20communications&rft.au=Nussbaum,%20Claudia&rft.date=2015-04-02&rft.volume=6&rft.issue=1&rft.spage=6416&rft.epage=6416&rft.pages=6416-6416&rft.artnum=6416&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/ncomms7416&rft_dat=%3Cproquest_pubme%3E3642795471%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1668242211&rft_id=info:pmid/25832730&rfr_iscdi=true