Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through...

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Veröffentlicht in:	Nature communications 2015-04, Vol.6 (1), p.6416-6416, Article 6416
Hauptverfasser:	Nussbaum, Claudia, Bannenberg, Sarah, Keul, Petra, Gräler, Markus H., Gonçalves-de-Albuquerque, Cassiano F., Korhonen, Hanna, von Wnuck Lipinski, Karin, Heusch, Gerd, de Castro Faria Neto, Hugo C., Rohwedder, Ina, Göthert, Joachim R., Prasad, Vysakh Pushpa, Haufe, Günter, Lange-Sperandio, Baerbel, Offermanns, Stefan, Sperandio, Markus, Levkau, Bodo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 13/95 14/1 14/63 631/250/249/2510/2100 631/45/287/1196 631/80/79 64/110 64/60 692/698/1543/1565/1597 Animals Calcium - metabolism Endothelium, Vascular - metabolism Epinephrine - metabolism GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism Histamine - metabolism Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans Immunohistochemistry Leukocyte Rolling - genetics Lysophospholipids - metabolism Male Mast Cells - metabolism Mice Mice, Knockout multidisciplinary Muscle, Skeletal - blood supply P-Selectin - metabolism Phospholipase C beta - metabolism Phosphotransferases (Alcohol Group Acceptor) - metabolism Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism Science Science (multidisciplinary) Sphingosine - analogs & derivatives Sphingosine - metabolism Venules
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