Longer-Term Outcomes After Kidney Transplantation From Seronegative Deceased Donors at Increased Risk for Blood-Borne Viral Infection

Transmission of human immunodeficiency virus and hepatitis C to transplant recipients has drawn attention of the use of allografts from seronegative donors at increased risk for blood-borne viral infection (DIRVI). We performed a cohort study of 7803 kidney transplant recipients whose kidneys were r...

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Veröffentlicht in:Transplantation 2011-06, Vol.91 (11), p.1211-1217
Hauptverfasser: REESE, Peter P, HALPERN, Scott D, DELAURO, Gina, BLUMBERG, Emily, WENG, Francis L, CAPLAN, Arthur, THOMASSON, Arwin, SHULTS, Justine, FELDMAN, Harold I, ASCH, David A, BLOOM, Roy, NATHAN, Howard, HASZ, Richard, ROTH, Joseph, REITSMA, William, KREFSKI, Louis, GOERLITZ, Fred
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Sprache:eng
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Zusammenfassung:Transmission of human immunodeficiency virus and hepatitis C to transplant recipients has drawn attention of the use of allografts from seronegative donors at increased risk for blood-borne viral infection (DIRVI). We performed a cohort study of 7803 kidney transplant recipients whose kidneys were recovered through one of two organ procurement organizations from 1996 to 2007. Detailed organ procurement organization data on donor risk factors were linked to recipient data from the Organ Procurement and Transplantation Network. Median recipient follow-up was 3.9 years. Three hundred sixty-eight (5%) patients received DIRVI kidneys, a third of which were procured from donors with a history of injection drug use or commercial sex work. Compared with standard criteria kidney recipients, DIRVI kidney recipients were more likely to be human immunodeficiency virus positive or black. In multivariable Cox regression, using DIRVI recipients as the reference, recipients of standard criteria donor kidneys had lower mortality (hazard ratio [HR] 0.71, P
ISSN:0041-1337
1534-6080
DOI:10.1097/TP.0b013e318218d59a