DNA replication fidelity and cancer

Abstract Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors ( p oint muta...

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Veröffentlicht in:Seminars in cancer biology 2010-10, Vol.20 (5), p.281-293
Hauptverfasser: Preston, Bradley D, Albertson, Tina M, Herr, Alan J
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors ( p oint mutation in stability or PIN) in carcinogenesis.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2010.10.009