DNA replication fidelity and cancer
Abstract Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors ( p oint muta...
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| Veröffentlicht in: | Seminars in cancer biology 2010-10, Vol.20 (5), p.281-293 |
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| container_title | Seminars in cancer biology |
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| creator | Preston, Bradley D Albertson, Tina M Herr, Alan J |
| description | Abstract Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors ( p oint mutation in stability or PIN) in carcinogenesis. |
| doi_str_mv | 10.1016/j.semcancer.2010.10.009 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1044-579X |
| ispartof | Seminars in cancer biology, 2010-10, Vol.20 (5), p.281-293 |
| issn | 1044-579X 1096-3650 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cancer Chromosome Aberrations DNA Damage DNA Mismatch Repair DNA polymerase DNA Repair - genetics DNA Replication - genetics DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Gene Rearrangement Hematology, Oncology and Palliative Medicine Humans Microsatellite Instability Mismatch repair Mutation Mutator Neoplasms - genetics Point Mutation Proofreading |
| title | DNA replication fidelity and cancer |
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