Molecular adaptation of Borrelia burgdorferi in the murine host
An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia burgdorferi, the Lyme disease spirochete. For the first step, regardless whether the initial inocula of B. burgdorferi expressed either all (cultured spirochetes)...
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Veröffentlicht in: | The Journal of experimental medicine 2002-07, Vol.196 (2), p.275-280 |
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description | An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia burgdorferi, the Lyme disease spirochete. For the first step, regardless whether the initial inocula of B. burgdorferi expressed either all (cultured spirochetes) or less than 40 (host-adapted spirochetes) of the 137 lipoprotein genes, the spirochetes were modulated to transcribe 116 of the genes within 10 d after being introduced to the murine host. This step of adaptation was induced by the microenvironment of the host tissue. During the second step, which was forced by host immune selection pressure and occurred between 17 and 30 d after infection, B. burgdorferi down-regulated most of the lipoprotein genes and expressed less than 40 of the 137 genes. This novel adaptation mechanism could be a critical step for B. burgdorferi to proceed to chronic infection, as the pathogen would be cleared at the early stage of infection if the spirochetes failed to undergo this process. |
doi_str_mv | 10.1084/jem.20020770 |
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For the first step, regardless whether the initial inocula of B. burgdorferi expressed either all (cultured spirochetes) or less than 40 (host-adapted spirochetes) of the 137 lipoprotein genes, the spirochetes were modulated to transcribe 116 of the genes within 10 d after being introduced to the murine host. This step of adaptation was induced by the microenvironment of the host tissue. During the second step, which was forced by host immune selection pressure and occurred between 17 and 30 d after infection, B. burgdorferi down-regulated most of the lipoprotein genes and expressed less than 40 of the 137 genes. This novel adaptation mechanism could be a critical step for B. burgdorferi to proceed to chronic infection, as the pathogen would be cleared at the early stage of infection if the spirochetes failed to undergo this process.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.20020770</identifier><identifier>PMID: 12119353</identifier><language>eng</language><publisher>United States: The Rockefeller University Press</publisher><subject>Adaptation, Physiological ; Animals ; Antibodies, Bacterial - biosynthesis ; Arachnid Vectors - microbiology ; Bacterial Proteins - genetics ; Borrelia burgdorferi - genetics ; Borrelia burgdorferi - growth & development ; Borrelia burgdorferi - immunology ; Borrelia burgdorferi - physiology ; Brief Definitive Report ; Gene Expression Profiling ; Genes, Bacterial ; Lipoproteins - genetics ; Lyme Disease - immunology ; Lyme Disease - microbiology ; Mice ; Mice, Inbred C3H ; Mice, SCID ; Oligonucleotide Array Sequence Analysis ; Ticks - microbiology</subject><ispartof>The Journal of experimental medicine, 2002-07, Vol.196 (2), p.275-280</ispartof><rights>Copyright © 2002, The Rockefeller University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-3385d0edd57b85633f90eae6ade9beab5d927b3f70115d4a18382adbd389fdea3</citedby><cites>FETCH-LOGICAL-c411t-3385d0edd57b85633f90eae6ade9beab5d927b3f70115d4a18382adbd389fdea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12119353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Fang Ting</creatorcontrib><creatorcontrib>Nelson, F Kenneth</creatorcontrib><creatorcontrib>Fikrig, Erol</creatorcontrib><title>Molecular adaptation of Borrelia burgdorferi in the murine host</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia burgdorferi, the Lyme disease spirochete. For the first step, regardless whether the initial inocula of B. burgdorferi expressed either all (cultured spirochetes) or less than 40 (host-adapted spirochetes) of the 137 lipoprotein genes, the spirochetes were modulated to transcribe 116 of the genes within 10 d after being introduced to the murine host. This step of adaptation was induced by the microenvironment of the host tissue. During the second step, which was forced by host immune selection pressure and occurred between 17 and 30 d after infection, B. burgdorferi down-regulated most of the lipoprotein genes and expressed less than 40 of the 137 genes. This novel adaptation mechanism could be a critical step for B. burgdorferi to proceed to chronic infection, as the pathogen would be cleared at the early stage of infection if the spirochetes failed to undergo this process.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Antibodies, Bacterial - biosynthesis</subject><subject>Arachnid Vectors - microbiology</subject><subject>Bacterial Proteins - genetics</subject><subject>Borrelia burgdorferi - genetics</subject><subject>Borrelia burgdorferi - growth & development</subject><subject>Borrelia burgdorferi - immunology</subject><subject>Borrelia burgdorferi - physiology</subject><subject>Brief Definitive Report</subject><subject>Gene Expression Profiling</subject><subject>Genes, Bacterial</subject><subject>Lipoproteins - genetics</subject><subject>Lyme Disease - immunology</subject><subject>Lyme Disease - microbiology</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, SCID</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Ticks - microbiology</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT1PwzAQhi0EoqWwMaNMTKTcxXHjLCCo-JJALDBbTnxpXSVxsRMk_j1BlK-J6aS7R6_e08PYIcIUQaanK2qmCUACWQZbbIwihTgXXG6z8bBNYgTIRmwvhBUApqmY7bIRJog5F3zMzh9cTWVfax9po9ed7qxrI1dFl857qq2Oit4vjPMVeRvZNuqWFDW9ty1FSxe6fbZT6TrQwWZO2PP11dP8Nr5_vLmbX9zHZYrYxZxLYYCMEVkhxYzzKgfSNNOG8oJ0IUyeZAWvMkAUJtUouUy0KQyXeWVI8wk7-8xd90VDpqS287pWa28b7d-U01b9vbR2qRbuVSXDo_kQN2HHmwDvXnoKnWpsKKmudUuuDyrDHIZe6b8gylRIATiAJ59g6V0InqrvNgjqQ40a1KgvNQN-9PuDH3jjgr8D6SqLYg</recordid><startdate>20020715</startdate><enddate>20020715</enddate><creator>Liang, Fang Ting</creator><creator>Nelson, F Kenneth</creator><creator>Fikrig, Erol</creator><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20020715</creationdate><title>Molecular adaptation of Borrelia burgdorferi in the murine host</title><author>Liang, Fang Ting ; Nelson, F Kenneth ; Fikrig, Erol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-3385d0edd57b85633f90eae6ade9beab5d927b3f70115d4a18382adbd389fdea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Antibodies, Bacterial - biosynthesis</topic><topic>Arachnid Vectors - microbiology</topic><topic>Bacterial Proteins - genetics</topic><topic>Borrelia burgdorferi - genetics</topic><topic>Borrelia burgdorferi - growth & development</topic><topic>Borrelia burgdorferi - immunology</topic><topic>Borrelia burgdorferi - physiology</topic><topic>Brief Definitive Report</topic><topic>Gene Expression Profiling</topic><topic>Genes, Bacterial</topic><topic>Lipoproteins - genetics</topic><topic>Lyme Disease - immunology</topic><topic>Lyme Disease - microbiology</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, SCID</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Ticks - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Fang Ting</creatorcontrib><creatorcontrib>Nelson, F Kenneth</creatorcontrib><creatorcontrib>Fikrig, Erol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Fang Ting</au><au>Nelson, F Kenneth</au><au>Fikrig, Erol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular adaptation of Borrelia burgdorferi in the murine host</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2002-07-15</date><risdate>2002</risdate><volume>196</volume><issue>2</issue><spage>275</spage><epage>280</epage><pages>275-280</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>An analysis of expression of 137 lipoprotein genes on the course of murine infection revealed a two-step molecular adaptation by Borrelia burgdorferi, the Lyme disease spirochete. For the first step, regardless whether the initial inocula of B. burgdorferi expressed either all (cultured spirochetes) or less than 40 (host-adapted spirochetes) of the 137 lipoprotein genes, the spirochetes were modulated to transcribe 116 of the genes within 10 d after being introduced to the murine host. This step of adaptation was induced by the microenvironment of the host tissue. During the second step, which was forced by host immune selection pressure and occurred between 17 and 30 d after infection, B. burgdorferi down-regulated most of the lipoprotein genes and expressed less than 40 of the 137 genes. This novel adaptation mechanism could be a critical step for B. burgdorferi to proceed to chronic infection, as the pathogen would be cleared at the early stage of infection if the spirochetes failed to undergo this process.</abstract><cop>United States</cop><pub>The Rockefeller University Press</pub><pmid>12119353</pmid><doi>10.1084/jem.20020770</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adaptation, Physiological Animals Antibodies, Bacterial - biosynthesis Arachnid Vectors - microbiology Bacterial Proteins - genetics Borrelia burgdorferi - genetics Borrelia burgdorferi - growth & development Borrelia burgdorferi - immunology Borrelia burgdorferi - physiology Brief Definitive Report Gene Expression Profiling Genes, Bacterial Lipoproteins - genetics Lyme Disease - immunology Lyme Disease - microbiology Mice Mice, Inbred C3H Mice, SCID Oligonucleotide Array Sequence Analysis Ticks - microbiology |
title | Molecular adaptation of Borrelia burgdorferi in the murine host |
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