The effect of membrane polarization on the time course of the end-plate current in frog sartorius muscle

1. Intracellular recordings of the end-plate current at different membrane potentials were made, using a voltage-clamp technique. 2. When the membrane potential is varied between about +40 and -120 mV, the half-decline time of the end-plate current increases from about 0·6 msec to about 1·6 msec....

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Veröffentlicht in:The Journal of physiology 1969-10, Vol.204 (2), p.493-502
1. Verfasser: Kordas, M
Format: Artikel
Sprache:eng
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Zusammenfassung:1. Intracellular recordings of the end-plate current at different membrane potentials were made, using a voltage-clamp technique. 2. When the membrane potential is varied between about +40 and -120 mV, the half-decline time of the end-plate current increases from about 0·6 msec to about 1·6 msec. 3. It is suggested that the stability of receptor—mediator complex is affected by the membrane potential.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1969.sp008926