The effect of membrane polarization on the time course of the end-plate current in frog sartorius muscle
1. Intracellular recordings of the end-plate current at different membrane potentials were made, using a voltage-clamp technique. 2. When the membrane potential is varied between about +40 and -120 mV, the half-decline time of the end-plate current increases from about 0·6 msec to about 1·6 msec....
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Veröffentlicht in: | The Journal of physiology 1969-10, Vol.204 (2), p.493-502 |
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Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | 1. Intracellular recordings of the end-plate current at different membrane potentials were made, using a voltage-clamp technique.
2. When the membrane potential is varied between about +40 and -120 mV, the half-decline time of the end-plate current increases
from about 0·6 msec to about 1·6 msec.
3. It is suggested that the stability of receptorâmediator complex is affected by the membrane potential. |
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ISSN: | 0022-3751 1469-7793 |
DOI: | 10.1113/jphysiol.1969.sp008926 |