Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway
Zearalenone (ZEA) and deoxynivalenol (DON) are two common mycotoxins produced by the genus and have potential immunotoxic effects that may lead to a weak immune response against bacterial infections. ( ), a food-borne pathogenic microorganism ubiquitous in the environment, actively multiplies in the...
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creator | Feng, Nannan Zhong, Fang Cai, Guodong Zheng, Wanglong Zou, Hui Gu, Jianhong Yuan, Yan Zhu, Guoqiang Liu, Zongping Bian, Jianchun |
description | Zearalenone (ZEA) and deoxynivalenol (DON) are two common mycotoxins produced by the genus
and have potential immunotoxic effects that may lead to a weak immune response against bacterial infections.
(
), a food-borne pathogenic microorganism ubiquitous in the environment, actively multiplies in the liver, where hepatocytes are capable of resistance through mediated innate immune responses. At present, it is not clear if ZEA and DON affect hepatocyte immune responses to
infection or the mechanisms involved. Therefore, in this study, in vivo and in vitro models were used to investigate the effects of ZEA and DON on the innate immune responses of hepatocytes and related molecules after
infection. In vivo studies revealed that ZEA and DON inhibited the toll-like receptors 2 (TLR2)/nuclear factor kappa-B (NFκB) pathway in the liver tissue of
-infected mice, downregulating the expression levels of Nitric oxide (NO), in the liver and repressing the immune response. In addition, ZEA and DON inhibited Lipoteichoic acid (LTA)-induced expression of TLR2 and myeloid differentiation factor 88 (MyD88) in Buffalo Rat Liver (BRL 3A) cells in vitro, downregulating the TLR2/NFκB signaling pathway and resulting in the decreased expression levels of NO, causing immunosuppressive effects. In summary, ZEA and DON can negatively regulate NO levels through TLR2/NFκB, inhibiting the innate immune responses of the liver, and aggravate
infections in mouse livers. |
doi_str_mv | 10.3390/ijms24119664 |
format | Article |
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and have potential immunotoxic effects that may lead to a weak immune response against bacterial infections.
(
), a food-borne pathogenic microorganism ubiquitous in the environment, actively multiplies in the liver, where hepatocytes are capable of resistance through mediated innate immune responses. At present, it is not clear if ZEA and DON affect hepatocyte immune responses to
infection or the mechanisms involved. Therefore, in this study, in vivo and in vitro models were used to investigate the effects of ZEA and DON on the innate immune responses of hepatocytes and related molecules after
infection. In vivo studies revealed that ZEA and DON inhibited the toll-like receptors 2 (TLR2)/nuclear factor kappa-B (NFκB) pathway in the liver tissue of
-infected mice, downregulating the expression levels of Nitric oxide (NO), in the liver and repressing the immune response. In addition, ZEA and DON inhibited Lipoteichoic acid (LTA)-induced expression of TLR2 and myeloid differentiation factor 88 (MyD88) in Buffalo Rat Liver (BRL 3A) cells in vitro, downregulating the TLR2/NFκB signaling pathway and resulting in the decreased expression levels of NO, causing immunosuppressive effects. In summary, ZEA and DON can negatively regulate NO levels through TLR2/NFκB, inhibiting the innate immune responses of the liver, and aggravate
infections in mouse livers.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24119664</identifier><identifier>PMID: 37298614</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Bacterial infections ; Cytokines ; Deoxynivalenol ; Edema ; Food contamination & poisoning ; Fusarium ; Fusarium - metabolism ; Gram-positive bacteria ; Hepatocytes ; Hepatocytes - metabolism ; Immune response ; Immune system ; Immunity, Innate ; In vivo methods and tests ; Infections ; Innate immunity ; Kinases ; Lipoteichoic acid ; Listeria ; Listeria monocytogenes ; Listeriosis ; Liver ; Mice ; Mycotoxins ; Mycotoxins - metabolism ; MyD88 protein ; NF-kappa B - metabolism ; NF-κB protein ; Nitric oxide ; Phosphorylation ; Protein expression ; Proteins ; Rats ; Signal Transduction ; TLR2 protein ; Toll-Like Receptor 2 - genetics ; Toll-Like Receptor 2 - metabolism ; Toll-like receptors ; Zearalenone ; Zearalenone - metabolism</subject><ispartof>International journal of molecular sciences, 2023-06, Vol.24 (11), p.9664</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-abe38ef0df7020cf87749c79c56beda4fcd75f5afef8043d446f07b3fa9405d23</cites><orcidid>0000-0001-9071-8363 ; 0000-0001-8023-0751 ; 0000-0002-0939-331X ; 0000-0002-1658-5328</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253956/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253956/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37298614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Nannan</creatorcontrib><creatorcontrib>Zhong, Fang</creatorcontrib><creatorcontrib>Cai, Guodong</creatorcontrib><creatorcontrib>Zheng, Wanglong</creatorcontrib><creatorcontrib>Zou, Hui</creatorcontrib><creatorcontrib>Gu, Jianhong</creatorcontrib><creatorcontrib>Yuan, Yan</creatorcontrib><creatorcontrib>Zhu, Guoqiang</creatorcontrib><creatorcontrib>Liu, Zongping</creatorcontrib><creatorcontrib>Bian, Jianchun</creatorcontrib><title>Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Zearalenone (ZEA) and deoxynivalenol (DON) are two common mycotoxins produced by the genus
and have potential immunotoxic effects that may lead to a weak immune response against bacterial infections.
(
), a food-borne pathogenic microorganism ubiquitous in the environment, actively multiplies in the liver, where hepatocytes are capable of resistance through mediated innate immune responses. At present, it is not clear if ZEA and DON affect hepatocyte immune responses to
infection or the mechanisms involved. Therefore, in this study, in vivo and in vitro models were used to investigate the effects of ZEA and DON on the innate immune responses of hepatocytes and related molecules after
infection. In vivo studies revealed that ZEA and DON inhibited the toll-like receptors 2 (TLR2)/nuclear factor kappa-B (NFκB) pathway in the liver tissue of
-infected mice, downregulating the expression levels of Nitric oxide (NO), in the liver and repressing the immune response. In addition, ZEA and DON inhibited Lipoteichoic acid (LTA)-induced expression of TLR2 and myeloid differentiation factor 88 (MyD88) in Buffalo Rat Liver (BRL 3A) cells in vitro, downregulating the TLR2/NFκB signaling pathway and resulting in the decreased expression levels of NO, causing immunosuppressive effects. In summary, ZEA and DON can negatively regulate NO levels through TLR2/NFκB, inhibiting the innate immune responses of the liver, and aggravate
infections in mouse livers.</description><subject>Animals</subject><subject>Bacterial infections</subject><subject>Cytokines</subject><subject>Deoxynivalenol</subject><subject>Edema</subject><subject>Food contamination & poisoning</subject><subject>Fusarium</subject><subject>Fusarium - metabolism</subject><subject>Gram-positive bacteria</subject><subject>Hepatocytes</subject><subject>Hepatocytes - metabolism</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity, Innate</subject><subject>In vivo methods and tests</subject><subject>Infections</subject><subject>Innate immunity</subject><subject>Kinases</subject><subject>Lipoteichoic acid</subject><subject>Listeria</subject><subject>Listeria monocytogenes</subject><subject>Listeriosis</subject><subject>Liver</subject><subject>Mice</subject><subject>Mycotoxins</subject><subject>Mycotoxins - metabolism</subject><subject>MyD88 protein</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB protein</subject><subject>Nitric oxide</subject><subject>Phosphorylation</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Rats</subject><subject>Signal Transduction</subject><subject>TLR2 protein</subject><subject>Toll-Like Receptor 2 - genetics</subject><subject>Toll-Like Receptor 2 - metabolism</subject><subject>Toll-like receptors</subject><subject>Zearalenone</subject><subject>Zearalenone - metabolism</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdks9u1DAQxiMEov-4cUaWuHDoUsd24viESmHbSktBS7lwiRxnvOtVYi-2U5oH48JD9Jnwdku1cJrxzO_7NGNNlr3M8VtKBT4xqz4QlueiLNmTbD9nhEwwLvnTnXwvOwhhhTGhpBDPsz3KiajKnO1nv6ZDkN4MPfo0KhfdrbEBfQfpZQfWWUDStugDuNvRmpv7Wofm0A4K0AWsZXRqjIAurZWb0PdDkswhrJ0NSasjeBSXgGYmpNRI1Du7kbgFWAhJp0FF4yxqxvRYmsZEYxf3kuvZnJxcTe9-v0dfzcLKbtP4IuPypxyPsmdadgFePMTD7Nv04_XZxWT2-fzy7HQ2UZTjOJEN0Ao0bjXHBCtdcc6E4kIVZQOtZFq1vNCF1KArzGjLWKkxb6iWguGiJfQwe7f1XQ9ND60CG9PH1GtveunH2klT_9uxZlkv3E2dY1JQUZTJ4c2Dg3c_Bgix7k1Q0HXSghtCTSrCyqoSXCT09X_oyg0-Lb6l0oCU0EQdbynlXQge9OM0Oa43B1HvHkTCX-1u8Aj_vQD6BxDit8o</recordid><startdate>20230602</startdate><enddate>20230602</enddate><creator>Feng, Nannan</creator><creator>Zhong, Fang</creator><creator>Cai, Guodong</creator><creator>Zheng, Wanglong</creator><creator>Zou, Hui</creator><creator>Gu, Jianhong</creator><creator>Yuan, Yan</creator><creator>Zhu, Guoqiang</creator><creator>Liu, Zongping</creator><creator>Bian, Jianchun</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9071-8363</orcidid><orcidid>https://orcid.org/0000-0001-8023-0751</orcidid><orcidid>https://orcid.org/0000-0002-0939-331X</orcidid><orcidid>https://orcid.org/0000-0002-1658-5328</orcidid></search><sort><creationdate>20230602</creationdate><title>Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway</title><author>Feng, Nannan ; Zhong, Fang ; Cai, Guodong ; Zheng, Wanglong ; Zou, Hui ; Gu, Jianhong ; Yuan, Yan ; Zhu, Guoqiang ; Liu, Zongping ; Bian, Jianchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-abe38ef0df7020cf87749c79c56beda4fcd75f5afef8043d446f07b3fa9405d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Bacterial infections</topic><topic>Cytokines</topic><topic>Deoxynivalenol</topic><topic>Edema</topic><topic>Food contamination & poisoning</topic><topic>Fusarium</topic><topic>Fusarium - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Nannan</au><au>Zhong, Fang</au><au>Cai, Guodong</au><au>Zheng, Wanglong</au><au>Zou, Hui</au><au>Gu, Jianhong</au><au>Yuan, Yan</au><au>Zhu, Guoqiang</au><au>Liu, Zongping</au><au>Bian, Jianchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-06-02</date><risdate>2023</risdate><volume>24</volume><issue>11</issue><spage>9664</spage><pages>9664-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Zearalenone (ZEA) and deoxynivalenol (DON) are two common mycotoxins produced by the genus
and have potential immunotoxic effects that may lead to a weak immune response against bacterial infections.
(
), a food-borne pathogenic microorganism ubiquitous in the environment, actively multiplies in the liver, where hepatocytes are capable of resistance through mediated innate immune responses. At present, it is not clear if ZEA and DON affect hepatocyte immune responses to
infection or the mechanisms involved. Therefore, in this study, in vivo and in vitro models were used to investigate the effects of ZEA and DON on the innate immune responses of hepatocytes and related molecules after
infection. In vivo studies revealed that ZEA and DON inhibited the toll-like receptors 2 (TLR2)/nuclear factor kappa-B (NFκB) pathway in the liver tissue of
-infected mice, downregulating the expression levels of Nitric oxide (NO), in the liver and repressing the immune response. In addition, ZEA and DON inhibited Lipoteichoic acid (LTA)-induced expression of TLR2 and myeloid differentiation factor 88 (MyD88) in Buffalo Rat Liver (BRL 3A) cells in vitro, downregulating the TLR2/NFκB signaling pathway and resulting in the decreased expression levels of NO, causing immunosuppressive effects. In summary, ZEA and DON can negatively regulate NO levels through TLR2/NFκB, inhibiting the innate immune responses of the liver, and aggravate
infections in mouse livers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37298614</pmid><doi>10.3390/ijms24119664</doi><orcidid>https://orcid.org/0000-0001-9071-8363</orcidid><orcidid>https://orcid.org/0000-0001-8023-0751</orcidid><orcidid>https://orcid.org/0000-0002-0939-331X</orcidid><orcidid>https://orcid.org/0000-0002-1658-5328</orcidid><oa>free_for_read</oa></addata></record> |
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source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
subjects | Animals Bacterial infections Cytokines Deoxynivalenol Edema Food contamination & poisoning Fusarium Fusarium - metabolism Gram-positive bacteria Hepatocytes Hepatocytes - metabolism Immune response Immune system Immunity, Innate In vivo methods and tests Infections Innate immunity Kinases Lipoteichoic acid Listeria Listeria monocytogenes Listeriosis Liver Mice Mycotoxins Mycotoxins - metabolism MyD88 protein NF-kappa B - metabolism NF-κB protein Nitric oxide Phosphorylation Protein expression Proteins Rats Signal Transduction TLR2 protein Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptors Zearalenone Zearalenone - metabolism |
title | Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway |
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