Fusarium Mycotoxins Zearalenone and Deoxynivalenol Reduce Hepatocyte Innate Immune Response after the Listeria monocytogenes Infection by Inhibiting the TLR2/NFκB Signaling Pathway

Zearalenone (ZEA) and deoxynivalenol (DON) are two common mycotoxins produced by the genus and have potential immunotoxic effects that may lead to a weak immune response against bacterial infections. ( ), a food-borne pathogenic microorganism ubiquitous in the environment, actively multiplies in the...

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Veröffentlicht in:	International journal of molecular sciences 2023-06, Vol.24 (11), p.9664
Hauptverfasser:	Feng, Nannan, Zhong, Fang, Cai, Guodong, Zheng, Wanglong, Zou, Hui, Gu, Jianhong, Yuan, Yan, Zhu, Guoqiang, Liu, Zongping, Bian, Jianchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial infections Cytokines Deoxynivalenol Edema Food contamination & poisoning Fusarium Fusarium - metabolism Gram-positive bacteria Hepatocytes Hepatocytes - metabolism Immune response Immune system Immunity, Innate In vivo methods and tests Infections Innate immunity Kinases Lipoteichoic acid Listeria Listeria monocytogenes Listeriosis Liver Mice Mycotoxins Mycotoxins - metabolism MyD88 protein NF-kappa B - metabolism NF-κB protein Nitric oxide Phosphorylation Protein expression Proteins Rats Signal Transduction TLR2 protein Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptors Zearalenone Zearalenone - metabolism
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