Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats
A nano-based delivery system was developed to improve the oral absorption of daidzein, which has poor hydrophilicity and lipophilicity. A daidzein-phospholipid complex (DPC) was firstly prepared to improve its lipophilicity, and then encapsulated into lipid nanocarriers (DLNs) to verify the effectiv...
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Veröffentlicht in: | Nanoscale 2011-04, Vol.3 (4), p.178-1787 |
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description | A nano-based delivery system was developed to improve the oral absorption of daidzein, which has poor hydrophilicity and lipophilicity. A daidzein-phospholipid complex (DPC) was firstly prepared to improve its lipophilicity, and then encapsulated into lipid nanocarriers (DLNs) to verify the effectiveness of the strategy in enhancing the oral delivery of daidzein. DLNs were spherical nanosized particles with evidently increased dissolution. DLNs were mainly distributed in stomach and proximal intestine of mice after oral administration, and the intestinal permeability of DLNs in rats was significantly improved when compared with that of daidzein solution. The peak concentration of daidzein in rats after oral administration of DPC and DLNs was 6833 ± 1112 ng mL
−1
and 14 512 ± 2390 ng mL
−1
, respectively, which was improved over 10-fold and 21-fold than that of free daidzein. Moreover, the areas under the concentration-time curve (AUC
0-
t
) of DPC and DLNs were enhanced by 3.62-fold and 6.87-fold compared with that of free daidzein. These results suggested that DLNs could be an effective strategy to improve the oral absorption of poor hydrophilic and lipophilic drugs like daidzein.
A nano-based delivery system with a view to improving the oral absorption of poor hydrophilic and lipophilic daidzein:
in vitro
characteristics and
in vivo
behavior in rats. |
doi_str_mv | 10.1039/c0nr00879f |
format | Article |
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−1
and 14 512 ± 2390 ng mL
−1
, respectively, which was improved over 10-fold and 21-fold than that of free daidzein. Moreover, the areas under the concentration-time curve (AUC
0-
t
) of DPC and DLNs were enhanced by 3.62-fold and 6.87-fold compared with that of free daidzein. These results suggested that DLNs could be an effective strategy to improve the oral absorption of poor hydrophilic and lipophilic drugs like daidzein.
A nano-based delivery system with a view to improving the oral absorption of poor hydrophilic and lipophilic daidzein:
in vitro
characteristics and
in vivo
behavior in rats.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/c0nr00879f</identifier><identifier>PMID: 21350765</identifier><language>eng</language><publisher>England</publisher><subject>Administration, Oral ; Animals ; Delivery systems ; Intestines - metabolism ; Isoflavones - administration & dosage ; Isoflavones - pharmacokinetics ; Lipids ; Lipophilicity ; Metabolic Clearance Rate ; Mice ; Nanocapsules - administration & dosage ; Nanocapsules - chemistry ; Nanocomposites ; Nanomaterials ; Nanostructure ; Organ Specificity ; Phospholipids - chemistry ; Rats ; Stomach - metabolism ; Strategy ; Tissue Distribution</subject><ispartof>Nanoscale, 2011-04, Vol.3 (4), p.178-1787</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-ef464533a5fe3bcb2130ae82dbb3421c1c614bae45e9b02eb3bf5d4f60ed5b1d3</citedby><cites>FETCH-LOGICAL-c367t-ef464533a5fe3bcb2130ae82dbb3421c1c614bae45e9b02eb3bf5d4f60ed5b1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21350765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Zhiwen</creatorcontrib><creatorcontrib>Huang, Yan</creatorcontrib><creatorcontrib>Gao, Fang</creatorcontrib><creatorcontrib>Bu, Huihui</creatorcontrib><creatorcontrib>Gu, Wangwen</creatorcontrib><creatorcontrib>Li, Yaping</creatorcontrib><title>Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>A nano-based delivery system was developed to improve the oral absorption of daidzein, which has poor hydrophilicity and lipophilicity. A daidzein-phospholipid complex (DPC) was firstly prepared to improve its lipophilicity, and then encapsulated into lipid nanocarriers (DLNs) to verify the effectiveness of the strategy in enhancing the oral delivery of daidzein. DLNs were spherical nanosized particles with evidently increased dissolution. DLNs were mainly distributed in stomach and proximal intestine of mice after oral administration, and the intestinal permeability of DLNs in rats was significantly improved when compared with that of daidzein solution. The peak concentration of daidzein in rats after oral administration of DPC and DLNs was 6833 ± 1112 ng mL
−1
and 14 512 ± 2390 ng mL
−1
, respectively, which was improved over 10-fold and 21-fold than that of free daidzein. Moreover, the areas under the concentration-time curve (AUC
0-
t
) of DPC and DLNs were enhanced by 3.62-fold and 6.87-fold compared with that of free daidzein. These results suggested that DLNs could be an effective strategy to improve the oral absorption of poor hydrophilic and lipophilic drugs like daidzein.
A nano-based delivery system with a view to improving the oral absorption of poor hydrophilic and lipophilic daidzein:
in vitro
characteristics and
in vivo
behavior in rats.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Delivery systems</subject><subject>Intestines - metabolism</subject><subject>Isoflavones - administration & dosage</subject><subject>Isoflavones - pharmacokinetics</subject><subject>Lipids</subject><subject>Lipophilicity</subject><subject>Metabolic Clearance Rate</subject><subject>Mice</subject><subject>Nanocapsules - administration & dosage</subject><subject>Nanocapsules - chemistry</subject><subject>Nanocomposites</subject><subject>Nanomaterials</subject><subject>Nanostructure</subject><subject>Organ Specificity</subject><subject>Phospholipids - chemistry</subject><subject>Rats</subject><subject>Stomach - metabolism</subject><subject>Strategy</subject><subject>Tissue Distribution</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVoyVd7yb1FPSUE3EqWLK9zK5uPBgK5tGczksasgm25I--S5g_kb8fByYZechhmmPfhZYaXsSMpvkuhqh9O9CTEoqyaHbafCy0ypcr8w3Y2eo8dpHQnhKmUUbtsL5eqEKUp9tnjOQT_gKHPhlVMU7VhCJ672A0t3vM2gkfP52UPfXRAFJASD91AcTNpkaDlYFOkYQyxP-Oh55swUuRuBQRuRAppDC5x6P0sbiK3uIJNiPS8IBjTJ_axgTbh55d-yP5cXvxe_spubq-ulz9vMqdMOWbYaKMLpaBoUFlnp0cE4CL31iqdSyedkdoC6gIrK3K0yjaF140R6AsrvTpkx7PvdP3fNaax7kJy2LbQY1ynemFkLipZmIk8eZeUppR5qZWWE3o6o45iSoRNPVDogP7VUtTPEdVvEU3w1xffte3Qb9HXTCbgywxQclv1P4Nv7-n14Bv1BIiFpY8</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Zhang, Zhiwen</creator><creator>Huang, Yan</creator><creator>Gao, Fang</creator><creator>Bu, Huihui</creator><creator>Gu, Wangwen</creator><creator>Li, Yaping</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201104</creationdate><title>Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats</title><author>Zhang, Zhiwen ; Huang, Yan ; Gao, Fang ; Bu, Huihui ; Gu, Wangwen ; Li, Yaping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-ef464533a5fe3bcb2130ae82dbb3421c1c614bae45e9b02eb3bf5d4f60ed5b1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Delivery systems</topic><topic>Intestines - metabolism</topic><topic>Isoflavones - administration & dosage</topic><topic>Isoflavones - pharmacokinetics</topic><topic>Lipids</topic><topic>Lipophilicity</topic><topic>Metabolic Clearance Rate</topic><topic>Mice</topic><topic>Nanocapsules - administration & dosage</topic><topic>Nanocapsules - chemistry</topic><topic>Nanocomposites</topic><topic>Nanomaterials</topic><topic>Nanostructure</topic><topic>Organ Specificity</topic><topic>Phospholipids - chemistry</topic><topic>Rats</topic><topic>Stomach - metabolism</topic><topic>Strategy</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Zhiwen</creatorcontrib><creatorcontrib>Huang, Yan</creatorcontrib><creatorcontrib>Gao, Fang</creatorcontrib><creatorcontrib>Bu, Huihui</creatorcontrib><creatorcontrib>Gu, Wangwen</creatorcontrib><creatorcontrib>Li, Yaping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Zhiwen</au><au>Huang, Yan</au><au>Gao, Fang</au><au>Bu, Huihui</au><au>Gu, Wangwen</au><au>Li, Yaping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2011-04</date><risdate>2011</risdate><volume>3</volume><issue>4</issue><spage>178</spage><epage>1787</epage><pages>178-1787</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>A nano-based delivery system was developed to improve the oral absorption of daidzein, which has poor hydrophilicity and lipophilicity. A daidzein-phospholipid complex (DPC) was firstly prepared to improve its lipophilicity, and then encapsulated into lipid nanocarriers (DLNs) to verify the effectiveness of the strategy in enhancing the oral delivery of daidzein. DLNs were spherical nanosized particles with evidently increased dissolution. DLNs were mainly distributed in stomach and proximal intestine of mice after oral administration, and the intestinal permeability of DLNs in rats was significantly improved when compared with that of daidzein solution. The peak concentration of daidzein in rats after oral administration of DPC and DLNs was 6833 ± 1112 ng mL
−1
and 14 512 ± 2390 ng mL
−1
, respectively, which was improved over 10-fold and 21-fold than that of free daidzein. Moreover, the areas under the concentration-time curve (AUC
0-
t
) of DPC and DLNs were enhanced by 3.62-fold and 6.87-fold compared with that of free daidzein. These results suggested that DLNs could be an effective strategy to improve the oral absorption of poor hydrophilic and lipophilic drugs like daidzein.
A nano-based delivery system with a view to improving the oral absorption of poor hydrophilic and lipophilic daidzein:
in vitro
characteristics and
in vivo
behavior in rats.</abstract><cop>England</cop><pmid>21350765</pmid><doi>10.1039/c0nr00879f</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
subjects | Administration, Oral Animals Delivery systems Intestines - metabolism Isoflavones - administration & dosage Isoflavones - pharmacokinetics Lipids Lipophilicity Metabolic Clearance Rate Mice Nanocapsules - administration & dosage Nanocapsules - chemistry Nanocomposites Nanomaterials Nanostructure Organ Specificity Phospholipids - chemistry Rats Stomach - metabolism Strategy Tissue Distribution |
title | Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats |
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