Daidzein-phospholipid complex loaded lipid nanocarriers improved oral absorption: in vitro characteristics and in vivo behavior in rats

A nano-based delivery system was developed to improve the oral absorption of daidzein, which has poor hydrophilicity and lipophilicity. A daidzein-phospholipid complex (DPC) was firstly prepared to improve its lipophilicity, and then encapsulated into lipid nanocarriers (DLNs) to verify the effectiv...

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Veröffentlicht in:	Nanoscale 2011-04, Vol.3 (4), p.178-1787
Hauptverfasser:	Zhang, Zhiwen, Huang, Yan, Gao, Fang, Bu, Huihui, Gu, Wangwen, Li, Yaping
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Delivery systems Intestines - metabolism Isoflavones - administration & dosage Isoflavones - pharmacokinetics Lipids Lipophilicity Metabolic Clearance Rate Mice Nanocapsules - administration & dosage Nanocapsules - chemistry Nanocomposites Nanomaterials Nanostructure Organ Specificity Phospholipids - chemistry Rats Stomach - metabolism Strategy Tissue Distribution
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