FAILURE OF FORMATION OF 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL INSUFFICIENCY
1,25-dihydroxycholecalciferol (1,25- D.H.C.C.) could not be detected in the serum of patients with chronic renal insufficiency after injection of radioactive cholecalciferol. These patients were comparable in degree of vitamin-D deficiency with controls who formed 1,25-D.H.C.C. It is suggested that...
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Veröffentlicht in: | The Lancet (British edition) 1973-03, Vol.301 (7804), p.626-628 |
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creator | Mawer, E.Barbara Taylor, CarolM Backhouse, Joan Lumb, G.A Stanbury, S.W |
description | 1,25-dihydroxycholecalciferol (1,25- D.H.C.C.) could not be detected in the serum of patients with chronic renal insufficiency after injection of radioactive cholecalciferol. These patients were comparable in degree of vitamin-D deficiency with controls who formed 1,25-D.H.C.C. It is suggested that inability to form this active metabolite of vitamin D contributes to the vitamin-D-resistant osteomalacia of chronic renal insufficiency. |
doi_str_mv | 10.1016/S0140-6736(73)92197-1 |
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These patients were comparable in degree of vitamin-D deficiency with controls who formed 1,25-D.H.C.C. It is suggested that inability to form this active metabolite of vitamin D contributes to the vitamin-D-resistant osteomalacia of chronic renal insufficiency.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(73)92197-1</identifier><identifier>PMID: 4121843</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biocompatibility ; Biomedical materials ; Calcitriol ; Calcium - metabolism ; Carbon Isotopes ; Cholecalciferol - metabolism ; Chromatography ; Chronic Kidney Disease-Mineral and Bone Disorder - metabolism ; Dihydroxycholecalciferols - biosynthesis ; Humans ; Hydroxycholecalciferols - biosynthesis ; Intestinal Absorption ; Kidney - metabolism ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - metabolism ; Kidneys ; Metabolites ; Osteomalacia ; Osteomalacia - etiology ; Patients ; Renal insufficiency ; Tritium ; Vitamin D ; Vitamin D Deficiency - complications ; Vitamin deficiency</subject><ispartof>The Lancet (British edition), 1973-03, Vol.301 (7804), p.626-628</ispartof><rights>1973</rights><rights>Copyright Elsevier Limited Mar 24, 1973</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-b66cccf76538ad15acbba4a9e9e0baa4788200d9f5511e49b9c74e44f298bebd3</citedby><cites>FETCH-LOGICAL-c388t-b66cccf76538ad15acbba4a9e9e0baa4788200d9f5511e49b9c74e44f298bebd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673673921971$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4121843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mawer, E.Barbara</creatorcontrib><creatorcontrib>Taylor, CarolM</creatorcontrib><creatorcontrib>Backhouse, Joan</creatorcontrib><creatorcontrib>Lumb, G.A</creatorcontrib><creatorcontrib>Stanbury, S.W</creatorcontrib><title>FAILURE OF FORMATION OF 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL INSUFFICIENCY</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>1,25-dihydroxycholecalciferol (1,25- D.H.C.C.) could not be detected in the serum of patients with chronic renal insufficiency after injection of radioactive cholecalciferol. 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It is suggested that inability to form this active metabolite of vitamin D contributes to the vitamin-D-resistant osteomalacia of chronic renal insufficiency.</description><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Calcitriol</subject><subject>Calcium - metabolism</subject><subject>Carbon Isotopes</subject><subject>Cholecalciferol - metabolism</subject><subject>Chromatography</subject><subject>Chronic Kidney Disease-Mineral and Bone Disorder - metabolism</subject><subject>Dihydroxycholecalciferols - biosynthesis</subject><subject>Humans</subject><subject>Hydroxycholecalciferols - biosynthesis</subject><subject>Intestinal Absorption</subject><subject>Kidney - metabolism</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidneys</subject><subject>Metabolites</subject><subject>Osteomalacia</subject><subject>Osteomalacia - etiology</subject><subject>Patients</subject><subject>Renal insufficiency</subject><subject>Tritium</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin deficiency</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r4zAQhsXSpZum-xMKhoXSQt1qbFkfpxJcuxG4NrgJNCchyzK4JHFqJQv77-s0IYde9iRG88w7w4PQFeB7wEAfXjEQ7FMW0hsW3ooABPPhBxoBYcSPCHs7Q6MT8gtdOPeOMSYUR-fonEAAnIQjNEsnMpuXiVekXlqUL5OZLPJ9AXdB5D_J6eKpLN4W8bTIkniSxTJNyiLzZO7F07LIZeyVST7Zf7zO01TGMsnjxSX62eils7-P7xjN02QWT_2seJZDim9Czrd-RakxpmE0CrmuIdKmqjTRwgqLK60J4zzAuBZNFAFYIiphGLGENIHgla3qcIyuD7mbvvvYWbdVq9YZu1zqte12TnEQmADHA_jnG_je7fr1cJsKAswpo5TxgYoOlOk753rbqE3frnT_TwFWe-fqy7naC1UsVF_OFQxzV8f0XbWy9WnqKHnoPx76dnDxt7W9cqa1a2Prtrdmq-qu_c-GT0WqiJQ</recordid><startdate>19730324</startdate><enddate>19730324</enddate><creator>Mawer, E.Barbara</creator><creator>Taylor, CarolM</creator><creator>Backhouse, Joan</creator><creator>Lumb, G.A</creator><creator>Stanbury, S.W</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19730324</creationdate><title>FAILURE OF FORMATION OF 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL INSUFFICIENCY</title><author>Mawer, E.Barbara ; Taylor, CarolM ; Backhouse, Joan ; Lumb, G.A ; Stanbury, S.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-b66cccf76538ad15acbba4a9e9e0baa4788200d9f5511e49b9c74e44f298bebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1973</creationdate><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Calcitriol</topic><topic>Calcium - metabolism</topic><topic>Carbon Isotopes</topic><topic>Cholecalciferol - metabolism</topic><topic>Chromatography</topic><topic>Chronic Kidney Disease-Mineral and Bone Disorder - metabolism</topic><topic>Dihydroxycholecalciferols - biosynthesis</topic><topic>Humans</topic><topic>Hydroxycholecalciferols - biosynthesis</topic><topic>Intestinal Absorption</topic><topic>Kidney - metabolism</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidneys</topic><topic>Metabolites</topic><topic>Osteomalacia</topic><topic>Osteomalacia - etiology</topic><topic>Patients</topic><topic>Renal insufficiency</topic><topic>Tritium</topic><topic>Vitamin D</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mawer, E.Barbara</creatorcontrib><creatorcontrib>Taylor, CarolM</creatorcontrib><creatorcontrib>Backhouse, Joan</creatorcontrib><creatorcontrib>Lumb, G.A</creatorcontrib><creatorcontrib>Stanbury, S.W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mawer, E.Barbara</au><au>Taylor, CarolM</au><au>Backhouse, Joan</au><au>Lumb, G.A</au><au>Stanbury, S.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FAILURE OF FORMATION OF 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL INSUFFICIENCY</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1973-03-24</date><risdate>1973</risdate><volume>301</volume><issue>7804</issue><spage>626</spage><epage>628</epage><pages>626-628</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>1,25-dihydroxycholecalciferol (1,25- D.H.C.C.) could not be detected in the serum of patients with chronic renal insufficiency after injection of radioactive cholecalciferol. These patients were comparable in degree of vitamin-D deficiency with controls who formed 1,25-D.H.C.C. It is suggested that inability to form this active metabolite of vitamin D contributes to the vitamin-D-resistant osteomalacia of chronic renal insufficiency.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>4121843</pmid><doi>10.1016/S0140-6736(73)92197-1</doi><tpages>3</tpages></addata></record> |
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subjects | Biocompatibility Biomedical materials Calcitriol Calcium - metabolism Carbon Isotopes Cholecalciferol - metabolism Chromatography Chronic Kidney Disease-Mineral and Bone Disorder - metabolism Dihydroxycholecalciferols - biosynthesis Humans Hydroxycholecalciferols - biosynthesis Intestinal Absorption Kidney - metabolism Kidney Failure, Chronic - complications Kidney Failure, Chronic - metabolism Kidneys Metabolites Osteomalacia Osteomalacia - etiology Patients Renal insufficiency Tritium Vitamin D Vitamin D Deficiency - complications Vitamin deficiency |
title | FAILURE OF FORMATION OF 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL INSUFFICIENCY |
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