FAILURE OF FORMATION OF 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL INSUFFICIENCY

1,25-dihydroxycholecalciferol (1,25- D.H.C.C.) could not be detected in the serum of patients with chronic renal insufficiency after injection of radioactive cholecalciferol. These patients were comparable in degree of vitamin-D deficiency with controls who formed 1,25-D.H.C.C. It is suggested that...

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Veröffentlicht in:	The Lancet (British edition) 1973-03, Vol.301 (7804), p.626-628
Hauptverfasser:	Mawer, E.Barbara, Taylor, CarolM, Backhouse, Joan, Lumb, G.A, Stanbury, S.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biomedical materials Calcitriol Calcium - metabolism Carbon Isotopes Cholecalciferol - metabolism Chromatography Chronic Kidney Disease-Mineral and Bone Disorder - metabolism Dihydroxycholecalciferols - biosynthesis Humans Hydroxycholecalciferols - biosynthesis Intestinal Absorption Kidney - metabolism Kidney Failure, Chronic - complications Kidney Failure, Chronic - metabolism Kidneys Metabolites Osteomalacia Osteomalacia - etiology Patients Renal insufficiency Tritium Vitamin D Vitamin D Deficiency - complications Vitamin deficiency
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Zusammenfassung:	1,25-dihydroxycholecalciferol (1,25- D.H.C.C.) could not be detected in the serum of patients with chronic renal insufficiency after injection of radioactive cholecalciferol. These patients were comparable in degree of vitamin-D deficiency with controls who formed 1,25-D.H.C.C. It is suggested that inability to form this active metabolite of vitamin D contributes to the vitamin-D-resistant osteomalacia of chronic renal insufficiency.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(73)92197-1