Association of class I, II, and III MHC gene products with systemic lupus erythematosus. Results of a Central European multicenter study

Class I, II, and III MHC gene products were examined in 248 Central European SLE patients. The previously reported association with HLA-A1, -B8 and -DR3, and C4AQ0 alleles was confirmed. The frequency of HLA-DR2 was also slightly elevated in SLE patients, while no increase in C4BQ0 alleles was obser...

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Veröffentlicht in:Rheumatology international 1989-07, Vol.9 (1), p.13-18
Hauptverfasser: Hartung, K, Fontana, A, Klar, M, Krippner, H, Jörgens, K, Lang, B, Peter, H H, Pichler, W J, Schendel, D, Robin-Winn, M
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Sprache:eng
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Zusammenfassung:Class I, II, and III MHC gene products were examined in 248 Central European SLE patients. The previously reported association with HLA-A1, -B8 and -DR3, and C4AQ0 alleles was confirmed. The frequency of HLA-DR2 was also slightly elevated in SLE patients, while no increase in C4BQ0 alleles was observed. Additional findings were a significantly increased frequency of HLA-B13 and a significant decrease of HLA-B44.
ISSN:0172-8172
1437-160X
DOI:10.1007/BF00270284