Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice

Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration ( pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe lo...

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Veröffentlicht in:Brain research 1988-08, Vol.458 (2), p.361-366
Hauptverfasser: Mendelsohn, L.G., Smith, M.C., Lucaites, V.L., Kerchner, G.A., Ghetti, B.
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Sprache:eng
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Zusammenfassung:Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration ( pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(88)90479-9