Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice
Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration ( pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe lo...
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Veröffentlicht in: | Brain research 1988-08, Vol.458 (2), p.361-366 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration (
pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of
pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in
pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum. |
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ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/0006-8993(88)90479-9 |