Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice
Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration ( pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe lo...
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| Veröffentlicht in: | Brain research 1988-08, Vol.458 (2), p.361-366 |
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| container_title | Brain research |
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| creator | Mendelsohn, L.G. Smith, M.C. Lucaites, V.L. Kerchner, G.A. Ghetti, B. |
| description | Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration (
pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of
pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in
pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum. |
| doi_str_mv | 10.1016/0006-8993(88)90479-9 |
| format | Article |
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pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of
pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in
pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(88)90479-9</identifier><identifier>PMID: 2850081</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Autoradiography ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Cerebellar Cortex - metabolism ; Cerebellar receptor ; Fundamental and applied biological sciences. Psychology ; Insulin-like growth factor II ; Insulin-Like Growth Factor II - metabolism ; Iodine Radioisotopes ; Mice ; Mice, Neurologic Mutants - metabolism ; Nerve Degeneration ; Purkinje cell degeneration mouse ; Purkinje Cells - metabolism ; Receptors, Cell Surface - metabolism ; Receptors, Somatomedin ; Reference Values ; Somatomedins - metabolism ; Species Specificity ; Vertebrates: nervous system and sense organs ; Weaver mouse</subject><ispartof>Brain research, 1988-08, Vol.458 (2), p.361-366</ispartof><rights>1988 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-154f8618d08e1d71bc2911d753dd629d6c3c480863afb4d8d9f19bb3ce5c4b173</citedby><cites>FETCH-LOGICAL-c417t-154f8618d08e1d71bc2911d753dd629d6c3c480863afb4d8d9f19bb3ce5c4b173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899388904799$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7084643$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2850081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mendelsohn, L.G.</creatorcontrib><creatorcontrib>Smith, M.C.</creatorcontrib><creatorcontrib>Lucaites, V.L.</creatorcontrib><creatorcontrib>Kerchner, G.A.</creatorcontrib><creatorcontrib>Ghetti, B.</creatorcontrib><title>Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration (
pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of
pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in
pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebellar Cortex - metabolism</subject><subject>Cerebellar receptor</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Insulin-like growth factor II</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>Iodine Radioisotopes</subject><subject>Mice</subject><subject>Mice, Neurologic Mutants - metabolism</subject><subject>Nerve Degeneration</subject><subject>Purkinje cell degeneration mouse</subject><subject>Purkinje Cells - metabolism</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Somatomedin</subject><subject>Reference Values</subject><subject>Somatomedins - metabolism</subject><subject>Species Specificity</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Weaver mouse</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vFCEUwInR1G31G2jCwRg9jMLAMnBp0jRWN2miBz0TBt5saWdgBaZVP4afWMbd7FFPPPJ-70_eD6EXlLyjhIr3hBDRSKXYGynfKsI71ahHaEVl1zai5eQxWh2Rp-g059v6ZUyRE3TSyjUhkq7Q74u5xGScj9tkdjfe4jFaM_pfpvgYcBywD3kefWhGfwd4m-JDucGDsbUKbzY4gYVdjXPlsIUEPYyjSdjGVODHUv8A5h4SNsHhL3O68-EWKjiO2MEWAqT9oGkuJhQ8eQvP0JPBjBmeH94z9O3qw9fLT83154-by4vrxnLalYau-SAFlY5IoK6jvW0VrcGaOSda5YRllksiBTNDz510aqCq75mFteU97dgZer3vu0vx-wy56MnnZTMTIM5Zd1IQwaj6L0jrLQVrZQX5HrQp5pxg0LvkJ5N-akr04kwvQvQiREup_zrTS_-Xh_5zP4E7Fh0k1fyrQ97k6mZIJlifj1hHJBecVex8j0E92r2HpLP1ECw4Xy0V7aL_9x5_ADGJtYw</recordid><startdate>19880823</startdate><enddate>19880823</enddate><creator>Mendelsohn, L.G.</creator><creator>Smith, M.C.</creator><creator>Lucaites, V.L.</creator><creator>Kerchner, G.A.</creator><creator>Ghetti, B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880823</creationdate><title>Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice</title><author>Mendelsohn, L.G. ; Smith, M.C. ; Lucaites, V.L. ; Kerchner, G.A. ; Ghetti, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-154f8618d08e1d71bc2911d753dd629d6c3c480863afb4d8d9f19bb3ce5c4b173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Cerebellar Cortex - metabolism</topic><topic>Cerebellar receptor</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Insulin-like growth factor II</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>Iodine Radioisotopes</topic><topic>Mice</topic><topic>Mice, Neurologic Mutants - metabolism</topic><topic>Nerve Degeneration</topic><topic>Purkinje cell degeneration mouse</topic><topic>Purkinje Cells - metabolism</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Somatomedin</topic><topic>Reference Values</topic><topic>Somatomedins - metabolism</topic><topic>Species Specificity</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Weaver mouse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mendelsohn, L.G.</creatorcontrib><creatorcontrib>Smith, M.C.</creatorcontrib><creatorcontrib>Lucaites, V.L.</creatorcontrib><creatorcontrib>Kerchner, G.A.</creatorcontrib><creatorcontrib>Ghetti, B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mendelsohn, L.G.</au><au>Smith, M.C.</au><au>Lucaites, V.L.</au><au>Kerchner, G.A.</au><au>Ghetti, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1988-08-23</date><risdate>1988</risdate><volume>458</volume><issue>2</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Autoradiography was used to visualize insulin-like growth factor II (IGF-II) receptors in the cerebellar cortex of weaver and Purkinje cell degeneration (
pcd) mice. These mutants were selected for their respective absence of granule or Purkinje cells. Histological preparations confirmed a severe loss of granule cells in the cerebella of weaver mutants and an absence of Purkinje cells in those of
pcd mutants. Autoradiographs showed specific IGF-II binding to the granule cell layer of the cerebellar cortex in control mice, and in
pcd specific IGF-II receptor sites are located on the granule cells of the cerebellum.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2850081</pmid><doi>10.1016/0006-8993(88)90479-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1988-08, Vol.458 (2), p.361-366 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoradiography Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellar Cortex - metabolism Cerebellar receptor Fundamental and applied biological sciences. Psychology Insulin-like growth factor II Insulin-Like Growth Factor II - metabolism Iodine Radioisotopes Mice Mice, Neurologic Mutants - metabolism Nerve Degeneration Purkinje cell degeneration mouse Purkinje Cells - metabolism Receptors, Cell Surface - metabolism Receptors, Somatomedin Reference Values Somatomedins - metabolism Species Specificity Vertebrates: nervous system and sense organs Weaver mouse |
| title | Autoradiographic localization of insulin-like growth factor II receptors in cerebellar cortex of weaver and Purkinje cell degeneration mutant mice |
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