Downregulation of Thyroid Hormone Receptor Subtype mRNA Levels by Amiodarone during Catecholamine Stress in Vitro
Amiodarone, a powerful antiarrhythmic drug, likely exerts its major effect by antagonism of thyroid hormone (T3), probably at the receptor level. T3 is known to regulate β-adrenergic receptor density in the heart but the effects of sympathomimetic drugs on thyroid hormone receptors (T3R) is not know...
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Veröffentlicht in: | Biochemical and biophysical research communications 1995-06, Vol.211 (3), p.991-996 |
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