Downregulation of Thyroid Hormone Receptor Subtype mRNA Levels by Amiodarone during Catecholamine Stress in Vitro

Amiodarone, a powerful antiarrhythmic drug, likely exerts its major effect by antagonism of thyroid hormone (T3), probably at the receptor level. T3 is known to regulate β-adrenergic receptor density in the heart but the effects of sympathomimetic drugs on thyroid hormone receptors (T3R) is not know...

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Veröffentlicht in:Biochemical and biophysical research communications 1995-06, Vol.211 (3), p.991-996
Hauptverfasser: Drvota, V., Bronnegard, M., Haggblad, J., Barkhem, T., Sylven, C.
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Sprache:eng
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