Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines

Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity. Synthese und Biologische Wirkung von 2‐Adam...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 1986, Vol.319 (9), p.830-834
Hauptverfasser: Kuźmierkiewicz, Wojciech, Sa̧czewski, Franciszek, Foks, Henryk, Kaliszan, Roman, Damasiewicz, Barbara, Nasal, Antoni, Radwańska, Aleksandra
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container_end_page 834
container_issue 9
container_start_page 830
container_title Archiv der Pharmazie (Weinheim)
container_volume 319
creator Kuźmierkiewicz, Wojciech
Sa̧czewski, Franciszek
Foks, Henryk
Kaliszan, Roman
Damasiewicz, Barbara
Nasal, Antoni
Radwańska, Aleksandra
description Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity. Synthese und Biologische Wirkung von 2‐Adamantylmethyl‐benzimidazolen und ‐imidazolinen Durch Zusammenschmelzen von Adamantanessigsäuren mit den entsprechenden Aminen wurden Benzimidazol‐ und Imidazolin‐Derivate mit einem 2‐Adamantylmethylsubstituenten erhalten. Einige der synthetisierten Verbindungen zeigen eine ausgeprägte kreislaufanregende und tuberculosstatische Wirkung.
doi_str_mv 10.1002/ardp.19863190910
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identifier ISSN: 0365-6233
ispartof Archiv der Pharmazie (Weinheim), 1986, Vol.319 (9), p.830-834
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1521-4184
language eng
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adamantane - analogs & derivatives
Adamantane - chemical synthesis
Adamantane - pharmacology
Animals
Antitubercular Agents - chemical synthesis
Benzimidazoles - chemical synthesis
Benzimidazoles - pharmacology
Cardiovascular Agents - chemical synthesis
Chemistry
Exact sciences and technology
Hemodynamics - drug effects
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Imidazoles - chemical synthesis
Imidazoles - pharmacology
In Vitro Techniques
Male
Muscle, Smooth, Vascular - drug effects
Mycobacterium tuberculosis - drug effects
Organic chemistry
Preparations and properties
Rats
Rats, Inbred Strains
title Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines
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