Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines
Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity. Synthese und Biologische Wirkung von 2‐Adam...
Gespeichert in:
Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 1986, Vol.319 (9), p.830-834 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 834 |
---|---|
container_issue | 9 |
container_start_page | 830 |
container_title | Archiv der Pharmazie (Weinheim) |
container_volume | 319 |
creator | Kuźmierkiewicz, Wojciech Sa̧czewski, Franciszek Foks, Henryk Kaliszan, Roman Damasiewicz, Barbara Nasal, Antoni Radwańska, Aleksandra |
description | Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity.
Synthese und Biologische Wirkung von 2‐Adamantylmethyl‐benzimidazolen und ‐imidazolinen
Durch Zusammenschmelzen von Adamantanessigsäuren mit den entsprechenden Aminen wurden Benzimidazol‐ und Imidazolin‐Derivate mit einem 2‐Adamantylmethylsubstituenten erhalten. Einige der synthetisierten Verbindungen zeigen eine ausgeprägte kreislaufanregende und tuberculosstatische Wirkung. |
doi_str_mv | 10.1002/ardp.19863190910 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77152402</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77152402</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3300-bde4306d3cd0fc2f1610ac9bc614a76f11050267a81921fd13288bdcb221ae6f3</originalsourceid><addsrcrecordid>eNqFkE1P3DAQhi3Uim6BOxekPVSoPQRm7NhJDj0s0EIrBAioKnGxHH8Ut06yxNm24dc3qw0reuJkWe_7zIweQnYRDhCAHqrWzA-wyAXDAgqEDTJBTjFJMU9fkQkwwRNBGXtD3sb4EwAYUL5JNhkUggqYkLubvu7ubbRxqmozPfJNaH54rcJ0pjv_23d-SBo3pcn7mVGVqrs-VLa778OH0taPvvJGPTZhxJOnv69t3CavnQrR7ozvFvn2-dPt8Vlyfnn65Xh2nmjGAJLS2JSBMEwbcJo6FAhKF6UWmKpMOETgQEWmciwoOoOM5nlpdEkpKisc2yL7q7nztnlY2NjJykdtQ1C1bRZRZtmgJAU6FGFV1G0TY2udnLe-Um0vEeRSp1zqlM90DsjeOHtRVtasgdHfkL8bcxUHaa5VtfZxXcuznPJ0ufnjqvbHB9u_uFbOrk-u_j8jWfE-dvbvmlftLykylnH5_eJU8it-xE_OvsoL9g-T7p7h</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77152402</pqid></control><display><type>article</type><title>Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kuźmierkiewicz, Wojciech ; Sa̧czewski, Franciszek ; Foks, Henryk ; Kaliszan, Roman ; Damasiewicz, Barbara ; Nasal, Antoni ; Radwańska, Aleksandra</creator><creatorcontrib>Kuźmierkiewicz, Wojciech ; Sa̧czewski, Franciszek ; Foks, Henryk ; Kaliszan, Roman ; Damasiewicz, Barbara ; Nasal, Antoni ; Radwańska, Aleksandra</creatorcontrib><description>Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity.
Synthese und Biologische Wirkung von 2‐Adamantylmethyl‐benzimidazolen und ‐imidazolinen
Durch Zusammenschmelzen von Adamantanessigsäuren mit den entsprechenden Aminen wurden Benzimidazol‐ und Imidazolin‐Derivate mit einem 2‐Adamantylmethylsubstituenten erhalten. Einige der synthetisierten Verbindungen zeigen eine ausgeprägte kreislaufanregende und tuberculosstatische Wirkung.</description><identifier>ISSN: 0365-6233</identifier><identifier>EISSN: 1521-4184</identifier><identifier>DOI: 10.1002/ardp.19863190910</identifier><identifier>PMID: 3096260</identifier><identifier>CODEN: ARPMAS</identifier><language>eng</language><publisher>Hannover: WILEY-VCH Verlag</publisher><subject>Adamantane - analogs & derivatives ; Adamantane - chemical synthesis ; Adamantane - pharmacology ; Animals ; Antitubercular Agents - chemical synthesis ; Benzimidazoles - chemical synthesis ; Benzimidazoles - pharmacology ; Cardiovascular Agents - chemical synthesis ; Chemistry ; Exact sciences and technology ; Hemodynamics - drug effects ; Heterocyclic compounds ; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings ; Imidazoles - chemical synthesis ; Imidazoles - pharmacology ; In Vitro Techniques ; Male ; Muscle, Smooth, Vascular - drug effects ; Mycobacterium tuberculosis - drug effects ; Organic chemistry ; Preparations and properties ; Rats ; Rats, Inbred Strains</subject><ispartof>Archiv der Pharmazie (Weinheim), 1986, Vol.319 (9), p.830-834</ispartof><rights>Copyright © 1986 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3300-bde4306d3cd0fc2f1610ac9bc614a76f11050267a81921fd13288bdcb221ae6f3</citedby><cites>FETCH-LOGICAL-c3300-bde4306d3cd0fc2f1610ac9bc614a76f11050267a81921fd13288bdcb221ae6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fardp.19863190910$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fardp.19863190910$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8782542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3096260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuźmierkiewicz, Wojciech</creatorcontrib><creatorcontrib>Sa̧czewski, Franciszek</creatorcontrib><creatorcontrib>Foks, Henryk</creatorcontrib><creatorcontrib>Kaliszan, Roman</creatorcontrib><creatorcontrib>Damasiewicz, Barbara</creatorcontrib><creatorcontrib>Nasal, Antoni</creatorcontrib><creatorcontrib>Radwańska, Aleksandra</creatorcontrib><title>Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines</title><title>Archiv der Pharmazie (Weinheim)</title><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><description>Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity.
Synthese und Biologische Wirkung von 2‐Adamantylmethyl‐benzimidazolen und ‐imidazolinen
Durch Zusammenschmelzen von Adamantanessigsäuren mit den entsprechenden Aminen wurden Benzimidazol‐ und Imidazolin‐Derivate mit einem 2‐Adamantylmethylsubstituenten erhalten. Einige der synthetisierten Verbindungen zeigen eine ausgeprägte kreislaufanregende und tuberculosstatische Wirkung.</description><subject>Adamantane - analogs & derivatives</subject><subject>Adamantane - chemical synthesis</subject><subject>Adamantane - pharmacology</subject><subject>Animals</subject><subject>Antitubercular Agents - chemical synthesis</subject><subject>Benzimidazoles - chemical synthesis</subject><subject>Benzimidazoles - pharmacology</subject><subject>Cardiovascular Agents - chemical synthesis</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Hemodynamics - drug effects</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings</subject><subject>Imidazoles - chemical synthesis</subject><subject>Imidazoles - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0365-6233</issn><issn>1521-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi3Uim6BOxekPVSoPQRm7NhJDj0s0EIrBAioKnGxHH8Ut06yxNm24dc3qw0reuJkWe_7zIweQnYRDhCAHqrWzA-wyAXDAgqEDTJBTjFJMU9fkQkwwRNBGXtD3sb4EwAYUL5JNhkUggqYkLubvu7ubbRxqmozPfJNaH54rcJ0pjv_23d-SBo3pcn7mVGVqrs-VLa778OH0taPvvJGPTZhxJOnv69t3CavnQrR7ozvFvn2-dPt8Vlyfnn65Xh2nmjGAJLS2JSBMEwbcJo6FAhKF6UWmKpMOETgQEWmciwoOoOM5nlpdEkpKisc2yL7q7nztnlY2NjJykdtQ1C1bRZRZtmgJAU6FGFV1G0TY2udnLe-Um0vEeRSp1zqlM90DsjeOHtRVtasgdHfkL8bcxUHaa5VtfZxXcuznPJ0ufnjqvbHB9u_uFbOrk-u_j8jWfE-dvbvmlftLykylnH5_eJU8it-xE_OvsoL9g-T7p7h</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Kuźmierkiewicz, Wojciech</creator><creator>Sa̧czewski, Franciszek</creator><creator>Foks, Henryk</creator><creator>Kaliszan, Roman</creator><creator>Damasiewicz, Barbara</creator><creator>Nasal, Antoni</creator><creator>Radwańska, Aleksandra</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines</title><author>Kuźmierkiewicz, Wojciech ; Sa̧czewski, Franciszek ; Foks, Henryk ; Kaliszan, Roman ; Damasiewicz, Barbara ; Nasal, Antoni ; Radwańska, Aleksandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3300-bde4306d3cd0fc2f1610ac9bc614a76f11050267a81921fd13288bdcb221ae6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adamantane - analogs & derivatives</topic><topic>Adamantane - chemical synthesis</topic><topic>Adamantane - pharmacology</topic><topic>Animals</topic><topic>Antitubercular Agents - chemical synthesis</topic><topic>Benzimidazoles - chemical synthesis</topic><topic>Benzimidazoles - pharmacology</topic><topic>Cardiovascular Agents - chemical synthesis</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Hemodynamics - drug effects</topic><topic>Heterocyclic compounds</topic><topic>Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings</topic><topic>Imidazoles - chemical synthesis</topic><topic>Imidazoles - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuźmierkiewicz, Wojciech</creatorcontrib><creatorcontrib>Sa̧czewski, Franciszek</creatorcontrib><creatorcontrib>Foks, Henryk</creatorcontrib><creatorcontrib>Kaliszan, Roman</creatorcontrib><creatorcontrib>Damasiewicz, Barbara</creatorcontrib><creatorcontrib>Nasal, Antoni</creatorcontrib><creatorcontrib>Radwańska, Aleksandra</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archiv der Pharmazie (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuźmierkiewicz, Wojciech</au><au>Sa̧czewski, Franciszek</au><au>Foks, Henryk</au><au>Kaliszan, Roman</au><au>Damasiewicz, Barbara</au><au>Nasal, Antoni</au><au>Radwańska, Aleksandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines</atitle><jtitle>Archiv der Pharmazie (Weinheim)</jtitle><addtitle>Arch. Pharm. Pharm. Med. Chem</addtitle><date>1986</date><risdate>1986</risdate><volume>319</volume><issue>9</issue><spage>830</spage><epage>834</epage><pages>830-834</pages><issn>0365-6233</issn><eissn>1521-4184</eissn><coden>ARPMAS</coden><abstract>Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity.
Synthese und Biologische Wirkung von 2‐Adamantylmethyl‐benzimidazolen und ‐imidazolinen
Durch Zusammenschmelzen von Adamantanessigsäuren mit den entsprechenden Aminen wurden Benzimidazol‐ und Imidazolin‐Derivate mit einem 2‐Adamantylmethylsubstituenten erhalten. Einige der synthetisierten Verbindungen zeigen eine ausgeprägte kreislaufanregende und tuberculosstatische Wirkung.</abstract><cop>Hannover</cop><pub>WILEY-VCH Verlag</pub><pmid>3096260</pmid><doi>10.1002/ardp.19863190910</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0365-6233 |
ispartof | Archiv der Pharmazie (Weinheim), 1986, Vol.319 (9), p.830-834 |
issn | 0365-6233 1521-4184 |
language | eng |
recordid | cdi_proquest_miscellaneous_77152402 |
source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Adamantane - analogs & derivatives Adamantane - chemical synthesis Adamantane - pharmacology Animals Antitubercular Agents - chemical synthesis Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Cardiovascular Agents - chemical synthesis Chemistry Exact sciences and technology Hemodynamics - drug effects Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imidazoles - chemical synthesis Imidazoles - pharmacology In Vitro Techniques Male Muscle, Smooth, Vascular - drug effects Mycobacterium tuberculosis - drug effects Organic chemistry Preparations and properties Rats Rats, Inbred Strains |
title | Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T19%3A38%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Syntheses%20and%20Biological%20Activities%20of%202-(Adamantylmethyl)benzimidazoles%20and%20-imidazolines&rft.jtitle=Archiv%20der%20Pharmazie%20(Weinheim)&rft.au=Ku%C5%BAmierkiewicz,%20Wojciech&rft.date=1986&rft.volume=319&rft.issue=9&rft.spage=830&rft.epage=834&rft.pages=830-834&rft.issn=0365-6233&rft.eissn=1521-4184&rft.coden=ARPMAS&rft_id=info:doi/10.1002/ardp.19863190910&rft_dat=%3Cproquest_cross%3E77152402%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77152402&rft_id=info:pmid/3096260&rfr_iscdi=true |