Syntheses and Biological Activities of 2-(Adamantylmethyl)benzimidazoles and -imidazolines

Derivatives of benzimidazole and imidazoline with a 2‐(adamantylmethyl) substituent were obtained by direct fusion of adamantaneacetic acids and suitable diamines. Some of the compounds synthesised show significant circulatory and tuberculostatic activity. Synthese und Biologische Wirkung von 2‐Adam...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1986, Vol.319 (9), p.830-834
Hauptverfasser:	Kuźmierkiewicz, Wojciech, Sa̧czewski, Franciszek, Foks, Henryk, Kaliszan, Roman, Damasiewicz, Barbara, Nasal, Antoni, Radwańska, Aleksandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemical synthesis Adamantane - pharmacology Animals Antitubercular Agents - chemical synthesis Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Cardiovascular Agents - chemical synthesis Chemistry Exact sciences and technology Hemodynamics - drug effects Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Imidazoles - chemical synthesis Imidazoles - pharmacology In Vitro Techniques Male Muscle, Smooth, Vascular - drug effects Mycobacterium tuberculosis - drug effects Organic chemistry Preparations and properties Rats Rats, Inbred Strains
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