X‐Ray, NMR, and Theoretical Studies of the Nootropic Agent BMY‐21502, a Pyrrolidinone Derivative

The preferred crystalline, solution, andin vacuoarrangements of 1‐[[1‐[2‐(trifluoromethyl)‐4‐pyrimidinyl]‐4‐piperidinyl]methyl]‐2‐pyrrolidinone (BMY‐21502) were investigated by means of single‐crystal X‐ray diffraction,1H and13C NMR spectroscopy, and semiempirical molecular orbital and molecular mec...

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Veröffentlicht in:Journal of pharmaceutical sciences 1994-06, Vol.83 (6), p.878-882
Hauptverfasser: Bandoli, Giuliano, Dolmella, Alessandro, Nicolini, Marino, Tisato, Francesco
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Sprache:eng
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Zusammenfassung:The preferred crystalline, solution, andin vacuoarrangements of 1‐[[1‐[2‐(trifluoromethyl)‐4‐pyrimidinyl]‐4‐piperidinyl]methyl]‐2‐pyrrolidinone (BMY‐21502) were investigated by means of single‐crystal X‐ray diffraction,1H and13C NMR spectroscopy, and semiempirical molecular orbital and molecular mechanics calculations. The X‐ray powder diffraction pattern is also reported.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600830624