A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control

Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was foun...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5460), p.2026-2029
Hauptverfasser: Odom, Audrey R., Stahlberg, Alke, Wente, Susan R., York, John D.
Format: Artikel
Sprache:eng
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Zusammenfassung:Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.287.5460.2026