A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was foun...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5460), p.2026-2029 |
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| creator | Odom, Audrey R. Stahlberg, Alke Wente, Susan R. York, John D. |
| description | Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression. |
| doi_str_mv | 10.1126/science.287.5460.2026 |
| format | Article |
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The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.287.5460.2026</identifier><identifier>PMID: 10720331</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Amino Acid Sequence ; Arginine - metabolism ; Biochemistry ; Biological and medical sciences ; Cell growth ; Cell Nucleus - enzymology ; Cell Nucleus - metabolism ; Cell regulation ; Cells ; Cells (Biology) ; Cellular control mechanisms ; DNA ; DNA-Binding Proteins - metabolism ; Eukaryotes ; Eukaryotic cells ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Fungal ; Genes ; Inositol 1,4,5-Trisphosphate - metabolism ; inositol 1,4,5-trisphosphate kinase ; Inositol Phosphates - metabolism ; Inositols ; Isomers ; Messenger RNA ; Minichromosome Maintenance 1 Protein ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nervous system ; Nitrogen ; Phosphoric Monoester Hydrolases - metabolism ; Phosphorylation ; Phosphotransferases (Alcohol Group Acceptor) - chemistry ; Phosphotransferases (Alcohol Group Acceptor) - metabolism ; Phytic Acid - metabolism ; Plasmids ; Polyphosphates ; Ribonucleic acid ; RNA ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - enzymology ; Saccharomyces cerevisiae - genetics ; Signal Transduction ; Transcription Factors - metabolism ; Transcription, Genetic ; Transcription. Transcription factor. Splicing. Rna processing ; Type C Phospholipases - metabolism ; Yeast ; Yeasts</subject><ispartof>Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5460), p.2026-2029</ispartof><rights>Copyright 2000 American Association for the Advancement of Science</rights><rights>2000 INIST-CNRS</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2000 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Mar 17, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c786t-758fa924841f3650e1dc0656437aa84785a7126c0cc21c3d07c251cd8202b1383</citedby><cites>FETCH-LOGICAL-c786t-758fa924841f3650e1dc0656437aa84785a7126c0cc21c3d07c251cd8202b1383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3074899$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3074899$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1348376$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10720331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Odom, Audrey R.</creatorcontrib><creatorcontrib>Stahlberg, Alke</creatorcontrib><creatorcontrib>Wente, Susan R.</creatorcontrib><creatorcontrib>York, John D.</creatorcontrib><title>A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.</description><subject>Amino Acid Sequence</subject><subject>Arginine - metabolism</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cell growth</subject><subject>Cell Nucleus - enzymology</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell regulation</subject><subject>Cells</subject><subject>Cells (Biology)</subject><subject>Cellular control mechanisms</subject><subject>DNA</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Eukaryotes</subject><subject>Eukaryotic cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genes</subject><subject>Inositol 1,4,5-Trisphosphate - metabolism</subject><subject>inositol 1,4,5-trisphosphate kinase</subject><subject>Inositol Phosphates - metabolism</subject><subject>Inositols</subject><subject>Isomers</subject><subject>Messenger RNA</subject><subject>Minichromosome Maintenance 1 Protein</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nervous system</subject><subject>Nitrogen</subject><subject>Phosphoric Monoester Hydrolases - metabolism</subject><subject>Phosphorylation</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - chemistry</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - metabolism</subject><subject>Phytic Acid - metabolism</subject><subject>Plasmids</subject><subject>Polyphosphates</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - enzymology</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Signal Transduction</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><subject>Transcription. Transcription factor. Splicing. 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Psychology</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genes</topic><topic>Inositol 1,4,5-Trisphosphate - metabolism</topic><topic>inositol 1,4,5-trisphosphate kinase</topic><topic>Inositol Phosphates - metabolism</topic><topic>Inositols</topic><topic>Isomers</topic><topic>Messenger RNA</topic><topic>Minichromosome Maintenance 1 Protein</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nervous system</topic><topic>Nitrogen</topic><topic>Phosphoric Monoester Hydrolases - metabolism</topic><topic>Phosphorylation</topic><topic>Phosphotransferases (Alcohol Group Acceptor) - chemistry</topic><topic>Phosphotransferases (Alcohol Group Acceptor) - metabolism</topic><topic>Phytic Acid - metabolism</topic><topic>Plasmids</topic><topic>Polyphosphates</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - enzymology</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Signal Transduction</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><topic>Transcription. Transcription factor. Splicing. 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The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>10720331</pmid><doi>10.1126/science.287.5460.2026</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2000-03, Vol.287 (5460), p.2026-2029 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743420376 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Amino Acid Sequence Arginine - metabolism Biochemistry Biological and medical sciences Cell growth Cell Nucleus - enzymology Cell Nucleus - metabolism Cell regulation Cells Cells (Biology) Cellular control mechanisms DNA DNA-Binding Proteins - metabolism Eukaryotes Eukaryotic cells Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Genes Inositol 1,4,5-Trisphosphate - metabolism inositol 1,4,5-trisphosphate kinase Inositol Phosphates - metabolism Inositols Isomers Messenger RNA Minichromosome Maintenance 1 Protein Molecular and cellular biology Molecular genetics Molecular Sequence Data Nervous system Nitrogen Phosphoric Monoester Hydrolases - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - metabolism Phytic Acid - metabolism Plasmids Polyphosphates Ribonucleic acid RNA Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Signal Transduction Transcription Factors - metabolism Transcription, Genetic Transcription. Transcription factor. Splicing. Rna processing Type C Phospholipases - metabolism Yeast Yeasts |
| title | A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control |
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