Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata

Abstract The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chry...

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Veröffentlicht in:Planta medica 2001-06, Vol.67 (4), p.340-344
Hauptverfasser: Bezabih, Merhatibeb, Abegaz, Berhanu M., Dufall, Kitiya, Croft, Kevin, Skinner-Adams, Tina, Davis, Timothy M. E.
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Sprache:eng
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Zusammenfassung:Abstract The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-C]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2001-14329