Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata
Abstract The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chry...
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| Veröffentlicht in: | Planta medica 2001-06, Vol.67 (4), p.340-344 |
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| container_title | Planta medica |
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| creator | Bezabih, Merhatibeb Abegaz, Berhanu M. Dufall, Kitiya Croft, Kevin Skinner-Adams, Tina Davis, Timothy M. E. |
| description | Abstract
The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-C]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities. |
| doi_str_mv | 10.1055/s-2001-14329 |
| format | Article |
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The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-C]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2001-14329</identifier><identifier>PMID: 11458451</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Antimalarials - chemistry ; Antimalarials - isolation & purification ; Antimalarials - pharmacology ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Biological and medical sciences ; Furans - chemistry ; Furans - isolation & purification ; Furans - pharmacology ; General pharmacology ; Humans ; Hypoxanthine - pharmacology ; Lipid Peroxides - analysis ; Lipoproteins, LDL - blood ; Magnetic Resonance Spectroscopy ; Medical sciences ; Molecular Structure ; Naphthoquinones - chemistry ; Naphthoquinones - isolation & purification ; Naphthoquinones - pharmacology ; Original Paper ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Roots - chemistry ; Plants, Medicinal - chemistry ; Plasmodium falciparum - drug effects</subject><ispartof>Planta medica, 2001-06, Vol.67 (4), p.340-344</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c665042350860650fac35745f7ecf5d0f1b4bcefb3c527f64c2d4f32e39db4793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-14329.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2001-14329$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3004,3005,27901,27902,54534,54535</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1044710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11458451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bezabih, Merhatibeb</creatorcontrib><creatorcontrib>Abegaz, Berhanu M.</creatorcontrib><creatorcontrib>Dufall, Kitiya</creatorcontrib><creatorcontrib>Croft, Kevin</creatorcontrib><creatorcontrib>Skinner-Adams, Tina</creatorcontrib><creatorcontrib>Davis, Timothy M. E.</creatorcontrib><title>Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-C]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.</description><subject>Animals</subject><subject>Antimalarials - chemistry</subject><subject>Antimalarials - isolation & purification</subject><subject>Antimalarials - pharmacology</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Furans - chemistry</subject><subject>Furans - isolation & purification</subject><subject>Furans - pharmacology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hypoxanthine - pharmacology</subject><subject>Lipid Peroxides - analysis</subject><subject>Lipoproteins, LDL - blood</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Naphthoquinones - chemistry</subject><subject>Naphthoquinones - isolation & purification</subject><subject>Naphthoquinones - pharmacology</subject><subject>Original Paper</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Roots - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Plasmodium falciparum - drug effects</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7ePEsOogetTr629rgufoEgiF68hDRN2Ejb1CYF_fem7oIexNMMw8M7Mw9CBwTOCQhxETIKQDLCGS020CTVIgNKySaaADCaQcHZDtoN4S1hvADYRjuEcHHJBZmg13kbXVer0PjKqRqrtsLjyH-4SrUR3wdvh161vlXdMi79--BSbwK2vW9wXBr85H0M2Ft8NdSlaw3WqnNRRbWHtqyqg9lf1yl6ubl-XtxlD4-394v5Q6a5gJjp2UwAp0zA5QxSa5VmIufC5kZbUYElJS-1sSXTguZ2xjWtuGXUsKIqeV6wKTpZ5XZ9Os-EKBsXtKlr1Ro_BJnnRKTPBUvk8f8kAZa00ASerUDd-xB6Y2XXu0b1n5KAHK3LIEfr8tt6wg_XuUPZmOoHXmtOwNEaUEGr2iah2oVfoZyPu6fodIXFpTONkW9-6Nuk7u-tX4Qyl4A</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Bezabih, Merhatibeb</creator><creator>Abegaz, Berhanu M.</creator><creator>Dufall, Kitiya</creator><creator>Croft, Kevin</creator><creator>Skinner-Adams, Tina</creator><creator>Davis, Timothy M. E.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata</title><author>Bezabih, Merhatibeb ; Abegaz, Berhanu M. ; Dufall, Kitiya ; Croft, Kevin ; Skinner-Adams, Tina ; Davis, Timothy M. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c665042350860650fac35745f7ecf5d0f1b4bcefb3c527f64c2d4f32e39db4793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Antimalarials - chemistry</topic><topic>Antimalarials - isolation & purification</topic><topic>Antimalarials - pharmacology</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Furans - chemistry</topic><topic>Furans - isolation & purification</topic><topic>Furans - pharmacology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hypoxanthine - pharmacology</topic><topic>Lipid Peroxides - analysis</topic><topic>Lipoproteins, LDL - blood</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Naphthoquinones - chemistry</topic><topic>Naphthoquinones - isolation & purification</topic><topic>Naphthoquinones - pharmacology</topic><topic>Original Paper</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Roots - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Plasmodium falciparum - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bezabih, Merhatibeb</creatorcontrib><creatorcontrib>Abegaz, Berhanu M.</creatorcontrib><creatorcontrib>Dufall, Kitiya</creatorcontrib><creatorcontrib>Croft, Kevin</creatorcontrib><creatorcontrib>Skinner-Adams, Tina</creatorcontrib><creatorcontrib>Davis, Timothy M. 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E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>67</volume><issue>4</issue><spage>340</spage><epage>344</epage><pages>340-344</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
The roots of B. CAPITATA yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-C]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-C]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-C]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10′-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-C]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-C]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-C]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>11458451</pmid><doi>10.1055/s-2001-14329</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences Furans - chemistry Furans - isolation & purification Furans - pharmacology General pharmacology Humans Hypoxanthine - pharmacology Lipid Peroxides - analysis Lipoproteins, LDL - blood Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Naphthoquinones - chemistry Naphthoquinones - isolation & purification Naphthoquinones - pharmacology Original Paper Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Roots - chemistry Plants, Medicinal - chemistry Plasmodium falciparum - drug effects |
| title | Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the Roots of Bulbine capitata |
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