Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl
In the footsteps of Victor Grignard: The simple LiCl‐mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, O...
Gespeichert in:
Veröffentlicht in: | Angewandte Chemie (International ed.) 2008-08, Vol.47 (36), p.6802-6806 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | In the footsteps of Victor Grignard: The simple LiCl‐mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, OTs, OBoc; Ts=p‐toluenesulfonyl, Boc=tert‐butylcarbonyloxy). |
---|---|
ISSN: | 1433-7851 1521-3773 |
DOI: | 10.1002/anie.200801968 |