Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl

In the footsteps of Victor Grignard: The simple LiCl‐mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, O...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2008-08, Vol.47 (36), p.6802-6806
Hauptverfasser:	Piller, Fabian M, Appukkuttan, Prasad, Gavryushin, Andrei, Helm, Matthew, Knochel, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	copper catalysis CC coupling Grignard reaction heterocycles insertion reactions
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creator	Piller, Fabian M Appukkuttan, Prasad Gavryushin, Andrei Helm, Matthew Knochel, Paul
description	In the footsteps of Victor Grignard: The simple LiCl‐mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, OTs, OBoc; Ts=p‐toluenesulfonyl, Boc=tert‐butylcarbonyloxy).
doi_str_mv	10.1002/anie.200801968
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subjects	copper catalysis CC coupling Grignard reaction heterocycles insertion reactions
title	Convenient Preparation of Polyfunctional Aryl Magnesium Reagents by a Direct Magnesium Insertion in the Presence of LiCl
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