Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea

Summary Background  Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to pl...

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Veröffentlicht in:British journal of dermatology (1951) 2008-07, Vol.159 (1), p.86-90
Hauptverfasser: Fawzi, M.M.T., Tawfik, S.O., Eissa, A.M., El-Komy, M.H.M., Abdel-Halim, M.R.E., Shaker, O.G.
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Sprache:eng
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Zusammenfassung:Summary Background  Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to play a role in some autoimmune connective tissue diseases and has been implicated in the pathogenesis of several fibrotic disorders. Objectives  To evaluate the role of IGF‐I in the pathogenesis of morphoea. Methods  The study was carried out on 15 patients with morphoea and nine healthy controls. Two 5‐mm punch skin biopsies were taken from every patient (one from lesional and one from non‐lesional skin) and a single biopsy was taken from the normal skin of each control. A 10‐mL blood sample was also taken from each patient and control. Quantitative detection of tissue and serum levels of IGF‐I was done using an enzyme‐linked immunosorbent assay technique. Results  IGF‐I in lesional skin was significantly higher than in non‐lesional and control skin (P = 0·001 and P = 0·021, respectively). Moreover, a significantly higher level of IGF‐I was detected in patient serum when compared with control serum (P 
ISSN:0007-0963
1365-2133
DOI:10.1111/j.1365-2133.2008.08592.x