Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea
Summary Background Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to pl...
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| Veröffentlicht in: | British journal of dermatology (1951) 2008-07, Vol.159 (1), p.86-90 |
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| container_title | British journal of dermatology (1951) |
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| creator | Fawzi, M.M.T. Tawfik, S.O. Eissa, A.M. El-Komy, M.H.M. Abdel-Halim, M.R.E. Shaker, O.G. |
| description | Summary
Background Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to play a role in some autoimmune connective tissue diseases and has been implicated in the pathogenesis of several fibrotic disorders.
Objectives To evaluate the role of IGF‐I in the pathogenesis of morphoea.
Methods The study was carried out on 15 patients with morphoea and nine healthy controls. Two 5‐mm punch skin biopsies were taken from every patient (one from lesional and one from non‐lesional skin) and a single biopsy was taken from the normal skin of each control. A 10‐mL blood sample was also taken from each patient and control. Quantitative detection of tissue and serum levels of IGF‐I was done using an enzyme‐linked immunosorbent assay technique.
Results IGF‐I in lesional skin was significantly higher than in non‐lesional and control skin (P = 0·001 and P = 0·021, respectively). Moreover, a significantly higher level of IGF‐I was detected in patient serum when compared with control serum (P |
| doi_str_mv | 10.1111/j.1365-2133.2008.08592.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69278957</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69278957</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4052-6c412e1a0c5e2e3eac8838974fd9942abb582ef325776b45e526c4f67a8756dc3</originalsourceid><addsrcrecordid>eNqNkM1OGzEUhS3UClLKKyCv2M3gn_HfoguaAqVCIKFCpW4sZ3KnOJmMp_ZECW9fD0nptt7Y8v2-c6WDEKakpPmcL0rKpSgY5bxkhOiSaGFYuT1Ak7fBOzQhhKiCGMmP0IeUFoRQTgQ5REdUV9pIoiaoudz2EVLyocOhwb5L69Z3ReuXgH_FsBmecePqIcTiJg9xCyPpWuy6Oe5CBv9-pKV_Tejd4KEbEt747K5C7J8DuI_ofePaBCf7-xg9Xl1-n34tbu-vb6YXt0VdEcEKWVeUAXWkFsCAg6u15tqoqpkbUzE3mwnNoOFMKCVnlQDBstJI5bQScl7zY3S2y-1j-L2GNNiVTzW0resgrJOVhilthMqg3oF1DClFaGwf_crFF0uJHTu2CztWaccq7dixfe3YbrN6ut-xnq1g_k_cl5qBTztg41t4-e9g-_nbl_GV_WLn-zTA9s13cWml4krYH3fX1jz9vCOVmdoH_gcGyJqO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69278957</pqid></control><display><type>article</type><title>Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Fawzi, M.M.T. ; Tawfik, S.O. ; Eissa, A.M. ; El-Komy, M.H.M. ; Abdel-Halim, M.R.E. ; Shaker, O.G.</creator><creatorcontrib>Fawzi, M.M.T. ; Tawfik, S.O. ; Eissa, A.M. ; El-Komy, M.H.M. ; Abdel-Halim, M.R.E. ; Shaker, O.G.</creatorcontrib><description>Summary
Background Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to play a role in some autoimmune connective tissue diseases and has been implicated in the pathogenesis of several fibrotic disorders.
Objectives To evaluate the role of IGF‐I in the pathogenesis of morphoea.
Methods The study was carried out on 15 patients with morphoea and nine healthy controls. Two 5‐mm punch skin biopsies were taken from every patient (one from lesional and one from non‐lesional skin) and a single biopsy was taken from the normal skin of each control. A 10‐mL blood sample was also taken from each patient and control. Quantitative detection of tissue and serum levels of IGF‐I was done using an enzyme‐linked immunosorbent assay technique.
Results IGF‐I in lesional skin was significantly higher than in non‐lesional and control skin (P = 0·001 and P = 0·021, respectively). Moreover, a significantly higher level of IGF‐I was detected in patient serum when compared with control serum (P < 0·001). A direct significant correlation existed between lesional and non‐lesional skin level (r = 0·618, P = 0·014), and between lesional skin level and Rodnan score (r = 0·538, P = 0·039).
Conclusions Despite the small sample size, this study suggests that IGF‐I plays an important role in the pathogenesis of fibrosis, characteristic of morphoea. Studies on a larger number of patients with morphoea as well as on patients with systemic sclerosis are recommended. Furthermore, therapeutic trials using IGF‐I antagonist (octreotide) are highly recommended in patients with morphoea.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2008.08592.x</identifier><identifier>PMID: 18489607</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Enzyme-Linked Immunosorbent Assay ; Female ; growth factors ; Humans ; Insulin-Like Growth Factor I - metabolism ; insulin-like growth factor-I ; Male ; Middle Aged ; morphoea ; scleroderma ; Scleroderma, Localized - etiology ; sclerosis</subject><ispartof>British journal of dermatology (1951), 2008-07, Vol.159 (1), p.86-90</ispartof><rights>2008 The Authors. Journal Compilation © 2008 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-6c412e1a0c5e2e3eac8838974fd9942abb582ef325776b45e526c4f67a8756dc3</citedby><cites>FETCH-LOGICAL-c4052-6c412e1a0c5e2e3eac8838974fd9942abb582ef325776b45e526c4f67a8756dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2008.08592.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2008.08592.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18489607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fawzi, M.M.T.</creatorcontrib><creatorcontrib>Tawfik, S.O.</creatorcontrib><creatorcontrib>Eissa, A.M.</creatorcontrib><creatorcontrib>El-Komy, M.H.M.</creatorcontrib><creatorcontrib>Abdel-Halim, M.R.E.</creatorcontrib><creatorcontrib>Shaker, O.G.</creatorcontrib><title>Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to play a role in some autoimmune connective tissue diseases and has been implicated in the pathogenesis of several fibrotic disorders.
Objectives To evaluate the role of IGF‐I in the pathogenesis of morphoea.
Methods The study was carried out on 15 patients with morphoea and nine healthy controls. Two 5‐mm punch skin biopsies were taken from every patient (one from lesional and one from non‐lesional skin) and a single biopsy was taken from the normal skin of each control. A 10‐mL blood sample was also taken from each patient and control. Quantitative detection of tissue and serum levels of IGF‐I was done using an enzyme‐linked immunosorbent assay technique.
Results IGF‐I in lesional skin was significantly higher than in non‐lesional and control skin (P = 0·001 and P = 0·021, respectively). Moreover, a significantly higher level of IGF‐I was detected in patient serum when compared with control serum (P < 0·001). A direct significant correlation existed between lesional and non‐lesional skin level (r = 0·618, P = 0·014), and between lesional skin level and Rodnan score (r = 0·538, P = 0·039).
Conclusions Despite the small sample size, this study suggests that IGF‐I plays an important role in the pathogenesis of fibrosis, characteristic of morphoea. Studies on a larger number of patients with morphoea as well as on patients with systemic sclerosis are recommended. Furthermore, therapeutic trials using IGF‐I antagonist (octreotide) are highly recommended in patients with morphoea.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>growth factors</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>insulin-like growth factor-I</subject><subject>Male</subject><subject>Middle Aged</subject><subject>morphoea</subject><subject>scleroderma</subject><subject>Scleroderma, Localized - etiology</subject><subject>sclerosis</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1OGzEUhS3UClLKKyCv2M3gn_HfoguaAqVCIKFCpW4sZ3KnOJmMp_ZECW9fD0nptt7Y8v2-c6WDEKakpPmcL0rKpSgY5bxkhOiSaGFYuT1Ak7fBOzQhhKiCGMmP0IeUFoRQTgQ5REdUV9pIoiaoudz2EVLyocOhwb5L69Z3ReuXgH_FsBmecePqIcTiJg9xCyPpWuy6Oe5CBv9-pKV_Tejd4KEbEt747K5C7J8DuI_ofePaBCf7-xg9Xl1-n34tbu-vb6YXt0VdEcEKWVeUAXWkFsCAg6u15tqoqpkbUzE3mwnNoOFMKCVnlQDBstJI5bQScl7zY3S2y-1j-L2GNNiVTzW0resgrJOVhilthMqg3oF1DClFaGwf_crFF0uJHTu2CztWaccq7dixfe3YbrN6ut-xnq1g_k_cl5qBTztg41t4-e9g-_nbl_GV_WLn-zTA9s13cWml4krYH3fX1jz9vCOVmdoH_gcGyJqO</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Fawzi, M.M.T.</creator><creator>Tawfik, S.O.</creator><creator>Eissa, A.M.</creator><creator>El-Komy, M.H.M.</creator><creator>Abdel-Halim, M.R.E.</creator><creator>Shaker, O.G.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea</title><author>Fawzi, M.M.T. ; Tawfik, S.O. ; Eissa, A.M. ; El-Komy, M.H.M. ; Abdel-Halim, M.R.E. ; Shaker, O.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-6c412e1a0c5e2e3eac8838974fd9942abb582ef325776b45e526c4f67a8756dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>growth factors</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>insulin-like growth factor-I</topic><topic>Male</topic><topic>Middle Aged</topic><topic>morphoea</topic><topic>scleroderma</topic><topic>Scleroderma, Localized - etiology</topic><topic>sclerosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fawzi, M.M.T.</creatorcontrib><creatorcontrib>Tawfik, S.O.</creatorcontrib><creatorcontrib>Eissa, A.M.</creatorcontrib><creatorcontrib>El-Komy, M.H.M.</creatorcontrib><creatorcontrib>Abdel-Halim, M.R.E.</creatorcontrib><creatorcontrib>Shaker, O.G.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fawzi, M.M.T.</au><au>Tawfik, S.O.</au><au>Eissa, A.M.</au><au>El-Komy, M.H.M.</au><au>Abdel-Halim, M.R.E.</au><au>Shaker, O.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>159</volume><issue>1</issue><spage>86</spage><epage>90</epage><pages>86-90</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>Summary
Background Morphoea (scleroderma) is a chronic disorder characterized by circumscribed sclerotic plaques with the hallmark of increased fibroblast activation and fibrosis. Through its effect on connective tissue cells and immune cells, insulin‐like growth factor (IGF)‐I has been found to play a role in some autoimmune connective tissue diseases and has been implicated in the pathogenesis of several fibrotic disorders.
Objectives To evaluate the role of IGF‐I in the pathogenesis of morphoea.
Methods The study was carried out on 15 patients with morphoea and nine healthy controls. Two 5‐mm punch skin biopsies were taken from every patient (one from lesional and one from non‐lesional skin) and a single biopsy was taken from the normal skin of each control. A 10‐mL blood sample was also taken from each patient and control. Quantitative detection of tissue and serum levels of IGF‐I was done using an enzyme‐linked immunosorbent assay technique.
Results IGF‐I in lesional skin was significantly higher than in non‐lesional and control skin (P = 0·001 and P = 0·021, respectively). Moreover, a significantly higher level of IGF‐I was detected in patient serum when compared with control serum (P < 0·001). A direct significant correlation existed between lesional and non‐lesional skin level (r = 0·618, P = 0·014), and between lesional skin level and Rodnan score (r = 0·538, P = 0·039).
Conclusions Despite the small sample size, this study suggests that IGF‐I plays an important role in the pathogenesis of fibrosis, characteristic of morphoea. Studies on a larger number of patients with morphoea as well as on patients with systemic sclerosis are recommended. Furthermore, therapeutic trials using IGF‐I antagonist (octreotide) are highly recommended in patients with morphoea.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18489607</pmid><doi>10.1111/j.1365-2133.2008.08592.x</doi><tpages>5</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Case-Control Studies Child Enzyme-Linked Immunosorbent Assay Female growth factors Humans Insulin-Like Growth Factor I - metabolism insulin-like growth factor-I Male Middle Aged morphoea scleroderma Scleroderma, Localized - etiology sclerosis |
| title | Expression of insulin-like growth factor-I in lesional and non-lesional skin of patients with morphoea |
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