Genotypic analysis of Mycobacterium leprae isolates from Japan and other Asian countries reveals a global transmission pattern of leprosy

Abstract The genotype of single-nucleotide polymorphism type 3, CTC, at positions 14676, 164275, and 2935685, along with four copies of 6bp repeats in the rpoT gene, was predominant for isolates originating in the Japanese mainland. Type 1, CGA, type 2, CTA, and type 3 were detected from Korea, Indo...

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Veröffentlicht in:FEMS microbiology letters 2006-08, Vol.261 (1), p.150-154
Hauptverfasser: Matsuoka, Masanori, Roa, Rocio Ivette Lopez, Budiawan, Teky, Kyaw, Kyaw, Chae, Gue-Tae
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Sprache:eng
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Zusammenfassung:Abstract The genotype of single-nucleotide polymorphism type 3, CTC, at positions 14676, 164275, and 2935685, along with four copies of 6bp repeats in the rpoT gene, was predominant for isolates originating in the Japanese mainland. Type 1, CGA, type 2, CTA, and type 3 were detected from Korea, Indonesia, and Myanmar. No isolates with four copies of 6bp were detected from Myanmar, Okinawa, and Japanese Brazilian patients. Type 4, TTC, with three copies of 6bp, was detected only from Japanese Brazilians. The results indicate that infection occurred in Brazil and the disease developed later in Japan.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2006.00346.x