The involvement of CaMKKI in activating AMPKα in yesso scallop Patinopecten yessoensis under high temperature stress

Calcium/calmodulin dependent protein kinase kinase (CaMKK), a highly conserved protein kinase, is involved in the downstream processes of various biological activities by phosphorylating and activating 5′-AMP-activated protein kinase (AMPK) in response to the increase of cytosolic-free calcium (Ca2+...

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Veröffentlicht in:Developmental and comparative immunology 2024-10, Vol.159, p.105227, Article 105227
Hauptverfasser: Tong, Ziling, Jiang, Dongli, Yang, Chuanyan, Li, Yinan, He, Zhaoyu, Ma, Xiaoxue, Wang, Lingling, Song, Linsheng
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Sprache:eng
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Zusammenfassung:Calcium/calmodulin dependent protein kinase kinase (CaMKK), a highly conserved protein kinase, is involved in the downstream processes of various biological activities by phosphorylating and activating 5′-AMP-activated protein kinase (AMPK) in response to the increase of cytosolic-free calcium (Ca2+). In the present study, a CaMKKI was identified from Yesso scallop Patinopecten yessoensis. Its mRNA was ubiquitously expressed in haemocytes and all tested tissues with the highest expression level in mantle. The expression level of PyCaMKKI mRNA in adductor muscle was significantly upregulated at 1, 3 and 6 h after high temperature treatment (25 °C), which was 3.43-fold (p 
ISSN:0145-305X
1879-0089
1879-0089
DOI:10.1016/j.dci.2024.105227