Microencapsulation of parathyroid cells via electric field and non-surgical transplantation approach

Purpose Hypoparathyroidism is a rare disease with low PTH, mostly seen as a consequence of neck surgery. Current management is the prescription of calcium and vitamin D, but the definitive treatment is parathyroid allotransplantation, which frequently triggers an immune response, thus cannot achieve...

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Veröffentlicht in:Journal of endocrinological investigation 2023-11, Vol.46 (11), p.2257-2267
Hauptverfasser: Karabıyık Acar, Ö., Başoğlu, H., Keğin, M., Nozhatzadeh, G. D., Hacıhasanoğlu, E., Tuncer, A. A., Şahin, F., Torun Köse, G., Aysan, E.
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Sprache:eng
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Zusammenfassung:Purpose Hypoparathyroidism is a rare disease with low PTH, mostly seen as a consequence of neck surgery. Current management is the prescription of calcium and vitamin D, but the definitive treatment is parathyroid allotransplantation, which frequently triggers an immune response, thus cannot achieve the expected success. To overcome this problem, encapsulation of allogeneic cells is the most promising method. By optimizing the standard alginate cell encapsulation technique with parathyroid cells under high-voltage application, the authors reduced the size of parathyroid-encapsulated beads and evaluated these samples in vitro and in vivo . Methods Parathyroid cells were isolated, and standard-sized alginate macrobeads were prepared without any electrical field application, while microbeads in smaller sizes (
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-023-02075-7