Branched chain amino acids are associated with metabolic complications in liver transplant recipients

Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (C...

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Veröffentlicht in:Clinical biochemistry 2022-04, Vol.102, p.26-33
Hauptverfasser: Böhler, Marco, van den Berg, Eline H., Almanza, Maria C.T., Connelly, Margery A., Bakker, Stephan J.L., de Meijer, Vincent E., Dullaart, Robin P.F., Blokzijl, Hans, Hak, E., Hepkema, B.G., Klont, F., Knobbe, T.J., Kremer, D., Leuvenink, H.G.D., Lexmond, W.S., Niesters, H.G.M., van Pelt, L.J., Pol, R.A., Porte, R.J., Ranchor, A.V., Sanders, J.S.F., Siebelink, M.J., Slart, R.J.H.J.A., Swarte, J.C., Touw, D.J., van den Heuvel, M.C., van Leer-Buter, C., van Londen, M., Verschuuren, E.A.M., Vos, M.J., Weersma, R.K.
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Sprache:eng
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Zusammenfassung:Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (CVD) risk profiles in several non-OLTx populations. Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients. 336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (P 
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2022.01.009