Branched chain amino acids are associated with metabolic complications in liver transplant recipients
Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (C...
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| Veröffentlicht in: | Clinical biochemistry 2022-04, Vol.102, p.26-33 |
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| creator | Böhler, Marco van den Berg, Eline H. Almanza, Maria C.T. Connelly, Margery A. Bakker, Stephan J.L. de Meijer, Vincent E. Dullaart, Robin P.F. Blokzijl, Hans Hak, E. Hepkema, B.G. Klont, F. Knobbe, T.J. Kremer, D. Leuvenink, H.G.D. Lexmond, W.S. Niesters, H.G.M. van Pelt, L.J. Pol, R.A. Porte, R.J. Ranchor, A.V. Sanders, J.S.F. Siebelink, M.J. Slart, R.J.H.J.A. Swarte, J.C. Touw, D.J. van den Heuvel, M.C. van Leer-Buter, C. van Londen, M. Verschuuren, E.A.M. Vos, M.J. Weersma, R.K. |
| description | Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (CVD) risk profiles in several non-OLTx populations.
Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients.
336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (P |
| doi_str_mv | 10.1016/j.clinbiochem.2022.01.009 |
| format | Article |
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Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients.
336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (P < 0.001) and T2D (P = 0.002) were significantly more frequent in subjects in the highest BCAA tertile. In logistic regression analyses, the multivariable adjusted odds ratio (OR) per 1 standard deviation increase in BCAA was 1.68 (95%CI: 1.18–2.20, P = 0.003) for MetS and 1.60 (95%CI: 1.14–2.23, P = 0.006) for T2D. Use of Sirolimus (mTOR inhibitor) was significantly associated with higher BCAA plasma levels, independent of age, sex, time after OLTx, MetS and other immunosuppressive medication (adjusted P = 0.002).
Elevated BCAA plasma levels are associated with T2D, MetS and use of Sirolimus in liver transplant recipients. BCAA plasma levels may represent a valuable biomarker for cardiometabolic complications after OLTx.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2022.01.009</identifier><identifier>PMID: 35143831</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acids, Branched-Chain - adverse effects ; Branched chain amino acids ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - complications ; Dyslipidemia ; Humans ; Liver Transplantation ; Metabolic syndrome ; Risk Factors ; Sirolimus ; Type 2 diabetes</subject><ispartof>Clinical biochemistry, 2022-04, Vol.102, p.26-33</ispartof><rights>2022 The Author(s)</rights><rights>Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-8e9552163e7e0f781fc251b371929e4071540992ce90569560844b2463b5a6ee3</citedby><cites>FETCH-LOGICAL-c428t-8e9552163e7e0f781fc251b371929e4071540992ce90569560844b2463b5a6ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912022000236$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35143831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Böhler, Marco</creatorcontrib><creatorcontrib>van den Berg, Eline H.</creatorcontrib><creatorcontrib>Almanza, Maria C.T.</creatorcontrib><creatorcontrib>Connelly, Margery A.</creatorcontrib><creatorcontrib>Bakker, Stephan J.L.</creatorcontrib><creatorcontrib>de Meijer, Vincent E.</creatorcontrib><creatorcontrib>Dullaart, Robin P.F.</creatorcontrib><creatorcontrib>Blokzijl, Hans</creatorcontrib><creatorcontrib>Hak, E.</creatorcontrib><creatorcontrib>Hepkema, B.G.</creatorcontrib><creatorcontrib>Klont, F.</creatorcontrib><creatorcontrib>Knobbe, T.J.</creatorcontrib><creatorcontrib>Kremer, D.</creatorcontrib><creatorcontrib>Leuvenink, H.G.D.</creatorcontrib><creatorcontrib>Lexmond, W.S.</creatorcontrib><creatorcontrib>Niesters, H.G.M.</creatorcontrib><creatorcontrib>van Pelt, L.J.</creatorcontrib><creatorcontrib>Pol, R.A.</creatorcontrib><creatorcontrib>Porte, R.J.</creatorcontrib><creatorcontrib>Ranchor, A.V.</creatorcontrib><creatorcontrib>Sanders, J.S.F.</creatorcontrib><creatorcontrib>Siebelink, M.J.</creatorcontrib><creatorcontrib>Slart, R.J.H.J.A.</creatorcontrib><creatorcontrib>Swarte, J.C.</creatorcontrib><creatorcontrib>Touw, D.J.</creatorcontrib><creatorcontrib>van den Heuvel, M.C.</creatorcontrib><creatorcontrib>van Leer-Buter, C.</creatorcontrib><creatorcontrib>van Londen, M.</creatorcontrib><creatorcontrib>Verschuuren, E.A.M.</creatorcontrib><creatorcontrib>Vos, M.J.</creatorcontrib><creatorcontrib>Weersma, R.K.</creatorcontrib><creatorcontrib>TransplantLines Investigators</creatorcontrib><title>Branched chain amino acids are associated with metabolic complications in liver transplant recipients</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (CVD) risk profiles in several non-OLTx populations.
Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients.
336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (P < 0.001) and T2D (P = 0.002) were significantly more frequent in subjects in the highest BCAA tertile. In logistic regression analyses, the multivariable adjusted odds ratio (OR) per 1 standard deviation increase in BCAA was 1.68 (95%CI: 1.18–2.20, P = 0.003) for MetS and 1.60 (95%CI: 1.14–2.23, P = 0.006) for T2D. Use of Sirolimus (mTOR inhibitor) was significantly associated with higher BCAA plasma levels, independent of age, sex, time after OLTx, MetS and other immunosuppressive medication (adjusted P = 0.002).
Elevated BCAA plasma levels are associated with T2D, MetS and use of Sirolimus in liver transplant recipients. BCAA plasma levels may represent a valuable biomarker for cardiometabolic complications after OLTx.</description><subject>Amino Acids, Branched-Chain - adverse effects</subject><subject>Branched chain amino acids</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Dyslipidemia</subject><subject>Humans</subject><subject>Liver Transplantation</subject><subject>Metabolic syndrome</subject><subject>Risk Factors</subject><subject>Sirolimus</subject><subject>Type 2 diabetes</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAURS0EomX4BWR2bBI8ZPISKiYJiQ2sLcd5VV-VxMF2i_h7XBUQS1ZPts69zz6EXHKWc8ar63VuexxbdHYFQy6YEDnjOWPqgMx5U8tMKCkPyZylq0xxwWbkJIR1OoqiqY7JTJa8kI3kcwK33oyppqN2ZXCkZsDRUWOxC9R4oCYEZ9HEBHxgXNEBomldj5ZaN0xpmohuDDRFe9yCpzH1hak3Y6QeLE4IYwxn5Ghp-gDn3_OUvN3fvS4es-eXh6fFzXNmC9HErAFVloJXEmpgy7rhSytK3sqaK6GgYDUvC6aUsKBYWamyYk1RtKKoZFuaCkCekqt97-Td-wZC1AMGC316DrhN0KISjWRc1HVC1R613oXgYaknj4Pxn5ozvbOs1_qPZb2zrBnXSWnKXnyv2bQDdL_JH60JWOwBSJ_dIngdbBJhocMkJerO4T_WfAFoQ5QB</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Böhler, Marco</creator><creator>van den Berg, Eline H.</creator><creator>Almanza, Maria C.T.</creator><creator>Connelly, Margery A.</creator><creator>Bakker, Stephan J.L.</creator><creator>de Meijer, Vincent E.</creator><creator>Dullaart, Robin P.F.</creator><creator>Blokzijl, Hans</creator><creator>Hak, E.</creator><creator>Hepkema, B.G.</creator><creator>Klont, F.</creator><creator>Knobbe, T.J.</creator><creator>Kremer, D.</creator><creator>Leuvenink, H.G.D.</creator><creator>Lexmond, W.S.</creator><creator>Niesters, H.G.M.</creator><creator>van Pelt, L.J.</creator><creator>Pol, R.A.</creator><creator>Porte, R.J.</creator><creator>Ranchor, A.V.</creator><creator>Sanders, J.S.F.</creator><creator>Siebelink, M.J.</creator><creator>Slart, R.J.H.J.A.</creator><creator>Swarte, J.C.</creator><creator>Touw, D.J.</creator><creator>van den Heuvel, M.C.</creator><creator>van Leer-Buter, C.</creator><creator>van Londen, M.</creator><creator>Verschuuren, E.A.M.</creator><creator>Vos, M.J.</creator><creator>Weersma, R.K.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220401</creationdate><title>Branched chain amino acids are associated with metabolic complications in liver transplant recipients</title><author>Böhler, Marco ; van den Berg, Eline H. ; Almanza, Maria C.T. ; Connelly, Margery A. ; Bakker, Stephan J.L. ; de Meijer, Vincent E. ; Dullaart, Robin P.F. ; Blokzijl, Hans ; Hak, E. ; Hepkema, B.G. ; Klont, F. ; Knobbe, T.J. ; Kremer, D. ; Leuvenink, H.G.D. ; Lexmond, W.S. ; Niesters, H.G.M. ; van Pelt, L.J. ; Pol, R.A. ; Porte, R.J. ; Ranchor, A.V. ; Sanders, J.S.F. ; Siebelink, M.J. ; Slart, R.J.H.J.A. ; Swarte, J.C. ; Touw, D.J. ; van den Heuvel, M.C. ; van Leer-Buter, C. ; van Londen, M. ; Verschuuren, E.A.M. ; Vos, M.J. ; Weersma, R.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-8e9552163e7e0f781fc251b371929e4071540992ce90569560844b2463b5a6ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amino Acids, Branched-Chain - adverse effects</topic><topic>Branched chain amino acids</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Dyslipidemia</topic><topic>Humans</topic><topic>Liver Transplantation</topic><topic>Metabolic syndrome</topic><topic>Risk Factors</topic><topic>Sirolimus</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Böhler, Marco</creatorcontrib><creatorcontrib>van den Berg, Eline H.</creatorcontrib><creatorcontrib>Almanza, Maria C.T.</creatorcontrib><creatorcontrib>Connelly, Margery A.</creatorcontrib><creatorcontrib>Bakker, Stephan J.L.</creatorcontrib><creatorcontrib>de Meijer, Vincent E.</creatorcontrib><creatorcontrib>Dullaart, Robin P.F.</creatorcontrib><creatorcontrib>Blokzijl, Hans</creatorcontrib><creatorcontrib>Hak, E.</creatorcontrib><creatorcontrib>Hepkema, B.G.</creatorcontrib><creatorcontrib>Klont, F.</creatorcontrib><creatorcontrib>Knobbe, T.J.</creatorcontrib><creatorcontrib>Kremer, D.</creatorcontrib><creatorcontrib>Leuvenink, H.G.D.</creatorcontrib><creatorcontrib>Lexmond, W.S.</creatorcontrib><creatorcontrib>Niesters, H.G.M.</creatorcontrib><creatorcontrib>van Pelt, L.J.</creatorcontrib><creatorcontrib>Pol, R.A.</creatorcontrib><creatorcontrib>Porte, R.J.</creatorcontrib><creatorcontrib>Ranchor, A.V.</creatorcontrib><creatorcontrib>Sanders, J.S.F.</creatorcontrib><creatorcontrib>Siebelink, M.J.</creatorcontrib><creatorcontrib>Slart, R.J.H.J.A.</creatorcontrib><creatorcontrib>Swarte, J.C.</creatorcontrib><creatorcontrib>Touw, D.J.</creatorcontrib><creatorcontrib>van den Heuvel, M.C.</creatorcontrib><creatorcontrib>van Leer-Buter, C.</creatorcontrib><creatorcontrib>van Londen, M.</creatorcontrib><creatorcontrib>Verschuuren, E.A.M.</creatorcontrib><creatorcontrib>Vos, M.J.</creatorcontrib><creatorcontrib>Weersma, R.K.</creatorcontrib><creatorcontrib>TransplantLines Investigators</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Böhler, Marco</au><au>van den Berg, Eline H.</au><au>Almanza, Maria C.T.</au><au>Connelly, Margery A.</au><au>Bakker, Stephan J.L.</au><au>de Meijer, Vincent E.</au><au>Dullaart, Robin P.F.</au><au>Blokzijl, Hans</au><au>Hak, E.</au><au>Hepkema, B.G.</au><au>Klont, F.</au><au>Knobbe, T.J.</au><au>Kremer, D.</au><au>Leuvenink, H.G.D.</au><au>Lexmond, W.S.</au><au>Niesters, H.G.M.</au><au>van Pelt, L.J.</au><au>Pol, R.A.</au><au>Porte, R.J.</au><au>Ranchor, A.V.</au><au>Sanders, J.S.F.</au><au>Siebelink, M.J.</au><au>Slart, R.J.H.J.A.</au><au>Swarte, J.C.</au><au>Touw, D.J.</au><au>van den Heuvel, M.C.</au><au>van Leer-Buter, C.</au><au>van Londen, M.</au><au>Verschuuren, E.A.M.</au><au>Vos, M.J.</au><au>Weersma, R.K.</au><aucorp>TransplantLines Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Branched chain amino acids are associated with metabolic complications in liver transplant recipients</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>102</volume><spage>26</spage><epage>33</epage><pages>26-33</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (CVD) risk profiles in several non-OLTx populations.
Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients.
336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (P < 0.001) and T2D (P = 0.002) were significantly more frequent in subjects in the highest BCAA tertile. In logistic regression analyses, the multivariable adjusted odds ratio (OR) per 1 standard deviation increase in BCAA was 1.68 (95%CI: 1.18–2.20, P = 0.003) for MetS and 1.60 (95%CI: 1.14–2.23, P = 0.006) for T2D. Use of Sirolimus (mTOR inhibitor) was significantly associated with higher BCAA plasma levels, independent of age, sex, time after OLTx, MetS and other immunosuppressive medication (adjusted P = 0.002).
Elevated BCAA plasma levels are associated with T2D, MetS and use of Sirolimus in liver transplant recipients. BCAA plasma levels may represent a valuable biomarker for cardiometabolic complications after OLTx.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35143831</pmid><doi>10.1016/j.clinbiochem.2022.01.009</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical biochemistry, 2022-04, Vol.102, p.26-33 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acids, Branched-Chain - adverse effects Branched chain amino acids Cohort Studies Cross-Sectional Studies Diabetes Mellitus, Type 2 - complications Dyslipidemia Humans Liver Transplantation Metabolic syndrome Risk Factors Sirolimus Type 2 diabetes |
| title | Branched chain amino acids are associated with metabolic complications in liver transplant recipients |
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