The yield of CSF molecular testing in febrile neonates

We retrospectively examined the yield of a cerebrospinal fluid (CSF) multiplex real-time PCR assay of febrile young infants undergoing a full sepsis work-up. Eighty infants were included in the study: Forty-nine (61%) neonates and 31 (39%) 29–90 day-old patients were included in the study. A viral p...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2021-07, Vol.40 (7), p.1553-1557
Hauptverfasser: Nassrallah, Basheer, Bamberger, Ellen, Cohen, Sarah, Srugo, Isaac, Golan-Shany, Orit, Shlonsky, Yulia, Mubariki, Raeda, Genizi, Jacob
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Sprache:eng
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Zusammenfassung:We retrospectively examined the yield of a cerebrospinal fluid (CSF) multiplex real-time PCR assay of febrile young infants undergoing a full sepsis work-up. Eighty infants were included in the study: Forty-nine (61%) neonates and 31 (39%) 29–90 day-old patients were included in the study. A viral pathogen was detected in 59% (47/80) of the samples, human enterovirus in 53% (42/80) and Human parechovirus in 6% (5/80). The CSF of nearly half of the subjects with CNS infection was without pleocytosis; all CSF cultures were negative. Multiplex PCR CSF testing enhances the diagnosis of pathogen-specific viral CNS infection among febrile young infants.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-021-04168-8