The yield of CSF molecular testing in febrile neonates
We retrospectively examined the yield of a cerebrospinal fluid (CSF) multiplex real-time PCR assay of febrile young infants undergoing a full sepsis work-up. Eighty infants were included in the study: Forty-nine (61%) neonates and 31 (39%) 29–90 day-old patients were included in the study. A viral p...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2021-07, Vol.40 (7), p.1553-1557 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Nassrallah, Basheer Bamberger, Ellen Cohen, Sarah Srugo, Isaac Golan-Shany, Orit Shlonsky, Yulia Mubariki, Raeda Genizi, Jacob |
| description | We retrospectively examined the yield of a cerebrospinal fluid (CSF) multiplex real-time PCR assay of febrile young infants undergoing a full sepsis work-up. Eighty infants were included in the study: Forty-nine (61%) neonates and 31 (39%) 29–90 day-old patients were included in the study. A viral pathogen was detected in 59% (47/80) of the samples, human enterovirus in 53% (42/80) and Human parechovirus in 6% (5/80). The CSF of nearly half of the subjects with CNS infection was without pleocytosis; all CSF cultures were negative. Multiplex PCR CSF testing enhances the diagnosis of pathogen-specific viral CNS infection among febrile young infants. |
| doi_str_mv | 10.1007/s10096-021-04168-8 |
| format | Article |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences Biomedicine Brief Report Cerebrospinal fluid Enteroviruses Infants Internal Medicine Medical Microbiology Multiplexing Neonates Pathogens Pleocytosis Sepsis |
| title | The yield of CSF molecular testing in febrile neonates |
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