New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus

Chemical investigation of the extracts of Aspergillus terreus resulted in the identification of terreusterpenes A-D (1-4), four new 3,5-dimethylorsellinic acid-based meroterpenoids. The structures and absolute configurations of 1-4 were elucidated by spectroscopic analyses including HRESIMS and 1D-...

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Veröffentlicht in:	Organic & biomolecular chemistry 2018-11, Vol.16 (46), p.9046-9052
Hauptverfasser:	Qi, Changxing, Qiao, Yuben, Gao, Weixi, Liu, Mengting, Zhou, Qun, Chen, Chunmei, Lai, Yongji, Xue, Yongbo, Zhang, Jinwen, Li, Dongyan, Wang, Jianping, Zhu, Hucheng, Hu, Zhengxi, Zhou, Yuan, Zhang, Yonghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Acids Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid precursor protein Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism Aspergillus - chemistry Aspergillus terreus Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Crystallography Crystallography, X-Ray GPI-Linked Proteins - antagonists & inhibitors GPI-Linked Proteins - metabolism Humans Medical treatment Models, Molecular Molecular Docking Simulation Neurodegenerative diseases NMR Nuclear magnetic resonance Organic chemistry Proteins Resorcinols - chemical synthesis Resorcinols - chemistry Resorcinols - pharmacology Single crystals Tetrahydrofuran X ray spectra X-ray diffraction β-Site APP-cleaving enzyme 1
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