New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus
Chemical investigation of the extracts of Aspergillus terreus resulted in the identification of terreusterpenes A-D (1-4), four new 3,5-dimethylorsellinic acid-based meroterpenoids. The structures and absolute configurations of 1-4 were elucidated by spectroscopic analyses including HRESIMS and 1D-...
Gespeichert in:
Veröffentlicht in: | Organic & biomolecular chemistry 2018-11, Vol.16 (46), p.9046-9052 |
---|---|
Hauptverfasser: | , , , , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 9052 |
---|---|
container_issue | 46 |
container_start_page | 9046 |
container_title | Organic & biomolecular chemistry |
container_volume | 16 |
creator | Qi, Changxing Qiao, Yuben Gao, Weixi Liu, Mengting Zhou, Qun Chen, Chunmei Lai, Yongji Xue, Yongbo Zhang, Jinwen Li, Dongyan Wang, Jianping Zhu, Hucheng Hu, Zhengxi Zhou, Yuan Zhang, Yonghui |
description | Chemical investigation of the extracts of Aspergillus terreus resulted in the identification of terreusterpenes A-D (1-4), four new 3,5-dimethylorsellinic acid-based meroterpenoids. The structures and absolute configurations of 1-4 were elucidated by spectroscopic analyses including HRESIMS and 1D- and 2D-NMR, chemical conversion, and single crystal X-ray diffraction. Terreusterpenes A (1) and B (2) featured 2,3,5-trimethyl-4-oxo-5-carboxy tetrahydrofuran moieties. Terreusterpene D (4) was characterized by a 4-hydroxy-3-methyl gamma lactone fragment that was generated by accident from the rearrangement of 3 in a mixed tetrahydrofuran-H2O-MeOH solvent. All these compounds were evaluated for the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and acetylcholinesterase (AchE) inhibitory activities. Among them, compounds 1 and 2 showed potentially significant BACE1 inhibitory activity, with IC50 values of 5.98 and 11.42 μM, respectively. Interestingly, compound 4 exhibited promising BACE1 and AchE inhibitory activities, with IC50 values of 1.91 and 8.86 μM, respectively, while 3 showed no such activity. Taken together, terreusterpenes A and B could be of great importance for the development of new BACE1 inhibitors, while terreusterpene D could serve as the first dual-targeted 3,5-dimethylorsellinic acid-based meroterpenoid for the treatment of Alzheimer's disease. |
doi_str_mv | 10.1039/c8ob02741b |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2133825789</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2138873494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-4e9e2ef51ee999b325e5fc6cf68ffeca59467137ce3c89af6af4ac0e1b3103583</originalsourceid><addsrcrecordid>eNpdkUtPwzAQhC0E4n3hByBLXBAiYMd2bB_bqjwkBBc4R46zpkZJXOyEqv-elNeB0-7hm9HuDEInlFxRwvS1VaEiueS02kL7lEuZEcH09t-ekz10kNIbIVTLgu-iPUY4I1TKfbR6hBVmlyKrfQv9Yt2EmKBpfOctNtbXWWUS1LiFGHqIS-iCrxNe-X6Bp5PZnGLT1XhiF3Psu4WvfB_iehT2_sP3HhJ2MbR4kpYQX33TDAmPLhGGdIR2nGkSHP_MQ_RyM3-e3WUPT7f3s8lDZpko-oyDhhycoABa64rlAoSzhXWFcg6sEZoXkjJpgVmljSuM48YSoBUboxGKHaLzb99lDO8DpL5sfbLjh6aDMKQyp4ypXEilR_TsH_oWhtiN120opSTjmo_UxTdlY0gpgiuX0bcmrktKyk0d5Uw9Tb_qmI7w6Y_lULVQ_6G_-bNPjK2GKQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2138873494</pqid></control><display><type>article</type><title>New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Qi, Changxing ; Qiao, Yuben ; Gao, Weixi ; Liu, Mengting ; Zhou, Qun ; Chen, Chunmei ; Lai, Yongji ; Xue, Yongbo ; Zhang, Jinwen ; Li, Dongyan ; Wang, Jianping ; Zhu, Hucheng ; Hu, Zhengxi ; Zhou, Yuan ; Zhang, Yonghui</creator><creatorcontrib>Qi, Changxing ; Qiao, Yuben ; Gao, Weixi ; Liu, Mengting ; Zhou, Qun ; Chen, Chunmei ; Lai, Yongji ; Xue, Yongbo ; Zhang, Jinwen ; Li, Dongyan ; Wang, Jianping ; Zhu, Hucheng ; Hu, Zhengxi ; Zhou, Yuan ; Zhang, Yonghui</creatorcontrib><description>Chemical investigation of the extracts of Aspergillus terreus resulted in the identification of terreusterpenes A-D (1-4), four new 3,5-dimethylorsellinic acid-based meroterpenoids. The structures and absolute configurations of 1-4 were elucidated by spectroscopic analyses including HRESIMS and 1D- and 2D-NMR, chemical conversion, and single crystal X-ray diffraction. Terreusterpenes A (1) and B (2) featured 2,3,5-trimethyl-4-oxo-5-carboxy tetrahydrofuran moieties. Terreusterpene D (4) was characterized by a 4-hydroxy-3-methyl gamma lactone fragment that was generated by accident from the rearrangement of 3 in a mixed tetrahydrofuran-H2O-MeOH solvent. All these compounds were evaluated for the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and acetylcholinesterase (AchE) inhibitory activities. Among them, compounds 1 and 2 showed potentially significant BACE1 inhibitory activity, with IC50 values of 5.98 and 11.42 μM, respectively. Interestingly, compound 4 exhibited promising BACE1 and AchE inhibitory activities, with IC50 values of 1.91 and 8.86 μM, respectively, while 3 showed no such activity. Taken together, terreusterpenes A and B could be of great importance for the development of new BACE1 inhibitors, while terreusterpene D could serve as the first dual-targeted 3,5-dimethylorsellinic acid-based meroterpenoid for the treatment of Alzheimer's disease.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/c8ob02741b</identifier><identifier>PMID: 30430177</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acetylcholinesterase ; Acetylcholinesterase - metabolism ; Acids ; Alzheimer Disease - drug therapy ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Amyloid precursor protein ; Amyloid Precursor Protein Secretases - antagonists & inhibitors ; Amyloid Precursor Protein Secretases - metabolism ; Aspartic Acid Endopeptidases - antagonists & inhibitors ; Aspartic Acid Endopeptidases - metabolism ; Aspergillus - chemistry ; Aspergillus terreus ; Cholinesterase Inhibitors - chemical synthesis ; Cholinesterase Inhibitors - chemistry ; Cholinesterase Inhibitors - pharmacology ; Crystallography ; Crystallography, X-Ray ; GPI-Linked Proteins - antagonists & inhibitors ; GPI-Linked Proteins - metabolism ; Humans ; Medical treatment ; Models, Molecular ; Molecular Docking Simulation ; Neurodegenerative diseases ; NMR ; Nuclear magnetic resonance ; Organic chemistry ; Proteins ; Resorcinols - chemical synthesis ; Resorcinols - chemistry ; Resorcinols - pharmacology ; Single crystals ; Tetrahydrofuran ; X ray spectra ; X-ray diffraction ; β-Site APP-cleaving enzyme 1</subject><ispartof>Organic & biomolecular chemistry, 2018-11, Vol.16 (46), p.9046-9052</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-4e9e2ef51ee999b325e5fc6cf68ffeca59467137ce3c89af6af4ac0e1b3103583</citedby><cites>FETCH-LOGICAL-c356t-4e9e2ef51ee999b325e5fc6cf68ffeca59467137ce3c89af6af4ac0e1b3103583</cites><orcidid>0000-0002-8881-1232 ; 0000-0002-6672-0014 ; 0000-0001-9133-6439 ; 0000-0003-4272-9003 ; 0000-0002-7222-2142 ; 0000-0002-1247-5615</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30430177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qi, Changxing</creatorcontrib><creatorcontrib>Qiao, Yuben</creatorcontrib><creatorcontrib>Gao, Weixi</creatorcontrib><creatorcontrib>Liu, Mengting</creatorcontrib><creatorcontrib>Zhou, Qun</creatorcontrib><creatorcontrib>Chen, Chunmei</creatorcontrib><creatorcontrib>Lai, Yongji</creatorcontrib><creatorcontrib>Xue, Yongbo</creatorcontrib><creatorcontrib>Zhang, Jinwen</creatorcontrib><creatorcontrib>Li, Dongyan</creatorcontrib><creatorcontrib>Wang, Jianping</creatorcontrib><creatorcontrib>Zhu, Hucheng</creatorcontrib><creatorcontrib>Hu, Zhengxi</creatorcontrib><creatorcontrib>Zhou, Yuan</creatorcontrib><creatorcontrib>Zhang, Yonghui</creatorcontrib><title>New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus</title><title>Organic & biomolecular chemistry</title><addtitle>Org Biomol Chem</addtitle><description>Chemical investigation of the extracts of Aspergillus terreus resulted in the identification of terreusterpenes A-D (1-4), four new 3,5-dimethylorsellinic acid-based meroterpenoids. The structures and absolute configurations of 1-4 were elucidated by spectroscopic analyses including HRESIMS and 1D- and 2D-NMR, chemical conversion, and single crystal X-ray diffraction. Terreusterpenes A (1) and B (2) featured 2,3,5-trimethyl-4-oxo-5-carboxy tetrahydrofuran moieties. Terreusterpene D (4) was characterized by a 4-hydroxy-3-methyl gamma lactone fragment that was generated by accident from the rearrangement of 3 in a mixed tetrahydrofuran-H2O-MeOH solvent. All these compounds were evaluated for the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and acetylcholinesterase (AchE) inhibitory activities. Among them, compounds 1 and 2 showed potentially significant BACE1 inhibitory activity, with IC50 values of 5.98 and 11.42 μM, respectively. Interestingly, compound 4 exhibited promising BACE1 and AchE inhibitory activities, with IC50 values of 1.91 and 8.86 μM, respectively, while 3 showed no such activity. Taken together, terreusterpenes A and B could be of great importance for the development of new BACE1 inhibitors, while terreusterpene D could serve as the first dual-targeted 3,5-dimethylorsellinic acid-based meroterpenoid for the treatment of Alzheimer's disease.</description><subject>Acetylcholinesterase</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Acids</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Amyloid precursor protein</subject><subject>Amyloid Precursor Protein Secretases - antagonists & inhibitors</subject><subject>Amyloid Precursor Protein Secretases - metabolism</subject><subject>Aspartic Acid Endopeptidases - antagonists & inhibitors</subject><subject>Aspartic Acid Endopeptidases - metabolism</subject><subject>Aspergillus - chemistry</subject><subject>Aspergillus terreus</subject><subject>Cholinesterase Inhibitors - chemical synthesis</subject><subject>Cholinesterase Inhibitors - chemistry</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Crystallography</subject><subject>Crystallography, X-Ray</subject><subject>GPI-Linked Proteins - antagonists & inhibitors</subject><subject>GPI-Linked Proteins - metabolism</subject><subject>Humans</subject><subject>Medical treatment</subject><subject>Models, Molecular</subject><subject>Molecular Docking Simulation</subject><subject>Neurodegenerative diseases</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organic chemistry</subject><subject>Proteins</subject><subject>Resorcinols - chemical synthesis</subject><subject>Resorcinols - chemistry</subject><subject>Resorcinols - pharmacology</subject><subject>Single crystals</subject><subject>Tetrahydrofuran</subject><subject>X ray spectra</subject><subject>X-ray diffraction</subject><subject>β-Site APP-cleaving enzyme 1</subject><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtPwzAQhC0E4n3hByBLXBAiYMd2bB_bqjwkBBc4R46zpkZJXOyEqv-elNeB0-7hm9HuDEInlFxRwvS1VaEiueS02kL7lEuZEcH09t-ekz10kNIbIVTLgu-iPUY4I1TKfbR6hBVmlyKrfQv9Yt2EmKBpfOctNtbXWWUS1LiFGHqIS-iCrxNe-X6Bp5PZnGLT1XhiF3Psu4WvfB_iehT2_sP3HhJ2MbR4kpYQX33TDAmPLhGGdIR2nGkSHP_MQ_RyM3-e3WUPT7f3s8lDZpko-oyDhhycoABa64rlAoSzhXWFcg6sEZoXkjJpgVmljSuM48YSoBUboxGKHaLzb99lDO8DpL5sfbLjh6aDMKQyp4ypXEilR_TsH_oWhtiN120opSTjmo_UxTdlY0gpgiuX0bcmrktKyk0d5Uw9Tb_qmI7w6Y_lULVQ_6G_-bNPjK2GKQ</recordid><startdate>20181128</startdate><enddate>20181128</enddate><creator>Qi, Changxing</creator><creator>Qiao, Yuben</creator><creator>Gao, Weixi</creator><creator>Liu, Mengting</creator><creator>Zhou, Qun</creator><creator>Chen, Chunmei</creator><creator>Lai, Yongji</creator><creator>Xue, Yongbo</creator><creator>Zhang, Jinwen</creator><creator>Li, Dongyan</creator><creator>Wang, Jianping</creator><creator>Zhu, Hucheng</creator><creator>Hu, Zhengxi</creator><creator>Zhou, Yuan</creator><creator>Zhang, Yonghui</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8881-1232</orcidid><orcidid>https://orcid.org/0000-0002-6672-0014</orcidid><orcidid>https://orcid.org/0000-0001-9133-6439</orcidid><orcidid>https://orcid.org/0000-0003-4272-9003</orcidid><orcidid>https://orcid.org/0000-0002-7222-2142</orcidid><orcidid>https://orcid.org/0000-0002-1247-5615</orcidid></search><sort><creationdate>20181128</creationdate><title>New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus</title><author>Qi, Changxing ; Qiao, Yuben ; Gao, Weixi ; Liu, Mengting ; Zhou, Qun ; Chen, Chunmei ; Lai, Yongji ; Xue, Yongbo ; Zhang, Jinwen ; Li, Dongyan ; Wang, Jianping ; Zhu, Hucheng ; Hu, Zhengxi ; Zhou, Yuan ; Zhang, Yonghui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-4e9e2ef51ee999b325e5fc6cf68ffeca59467137ce3c89af6af4ac0e1b3103583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acetylcholinesterase</topic><topic>Acetylcholinesterase - metabolism</topic><topic>Acids</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Amyloid precursor protein</topic><topic>Amyloid Precursor Protein Secretases - antagonists & inhibitors</topic><topic>Amyloid Precursor Protein Secretases - metabolism</topic><topic>Aspartic Acid Endopeptidases - antagonists & inhibitors</topic><topic>Aspartic Acid Endopeptidases - metabolism</topic><topic>Aspergillus - chemistry</topic><topic>Aspergillus terreus</topic><topic>Cholinesterase Inhibitors - chemical synthesis</topic><topic>Cholinesterase Inhibitors - chemistry</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Crystallography</topic><topic>Crystallography, X-Ray</topic><topic>GPI-Linked Proteins - antagonists & inhibitors</topic><topic>GPI-Linked Proteins - metabolism</topic><topic>Humans</topic><topic>Medical treatment</topic><topic>Models, Molecular</topic><topic>Molecular Docking Simulation</topic><topic>Neurodegenerative diseases</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organic chemistry</topic><topic>Proteins</topic><topic>Resorcinols - chemical synthesis</topic><topic>Resorcinols - chemistry</topic><topic>Resorcinols - pharmacology</topic><topic>Single crystals</topic><topic>Tetrahydrofuran</topic><topic>X ray spectra</topic><topic>X-ray diffraction</topic><topic>β-Site APP-cleaving enzyme 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qi, Changxing</creatorcontrib><creatorcontrib>Qiao, Yuben</creatorcontrib><creatorcontrib>Gao, Weixi</creatorcontrib><creatorcontrib>Liu, Mengting</creatorcontrib><creatorcontrib>Zhou, Qun</creatorcontrib><creatorcontrib>Chen, Chunmei</creatorcontrib><creatorcontrib>Lai, Yongji</creatorcontrib><creatorcontrib>Xue, Yongbo</creatorcontrib><creatorcontrib>Zhang, Jinwen</creatorcontrib><creatorcontrib>Li, Dongyan</creatorcontrib><creatorcontrib>Wang, Jianping</creatorcontrib><creatorcontrib>Zhu, Hucheng</creatorcontrib><creatorcontrib>Hu, Zhengxi</creatorcontrib><creatorcontrib>Zhou, Yuan</creatorcontrib><creatorcontrib>Zhang, Yonghui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qi, Changxing</au><au>Qiao, Yuben</au><au>Gao, Weixi</au><au>Liu, Mengting</au><au>Zhou, Qun</au><au>Chen, Chunmei</au><au>Lai, Yongji</au><au>Xue, Yongbo</au><au>Zhang, Jinwen</au><au>Li, Dongyan</au><au>Wang, Jianping</au><au>Zhu, Hucheng</au><au>Hu, Zhengxi</au><au>Zhou, Yuan</au><au>Zhang, Yonghui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus</atitle><jtitle>Organic & biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2018-11-28</date><risdate>2018</risdate><volume>16</volume><issue>46</issue><spage>9046</spage><epage>9052</epage><pages>9046-9052</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>Chemical investigation of the extracts of Aspergillus terreus resulted in the identification of terreusterpenes A-D (1-4), four new 3,5-dimethylorsellinic acid-based meroterpenoids. The structures and absolute configurations of 1-4 were elucidated by spectroscopic analyses including HRESIMS and 1D- and 2D-NMR, chemical conversion, and single crystal X-ray diffraction. Terreusterpenes A (1) and B (2) featured 2,3,5-trimethyl-4-oxo-5-carboxy tetrahydrofuran moieties. Terreusterpene D (4) was characterized by a 4-hydroxy-3-methyl gamma lactone fragment that was generated by accident from the rearrangement of 3 in a mixed tetrahydrofuran-H2O-MeOH solvent. All these compounds were evaluated for the β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) and acetylcholinesterase (AchE) inhibitory activities. Among them, compounds 1 and 2 showed potentially significant BACE1 inhibitory activity, with IC50 values of 5.98 and 11.42 μM, respectively. Interestingly, compound 4 exhibited promising BACE1 and AchE inhibitory activities, with IC50 values of 1.91 and 8.86 μM, respectively, while 3 showed no such activity. Taken together, terreusterpenes A and B could be of great importance for the development of new BACE1 inhibitors, while terreusterpene D could serve as the first dual-targeted 3,5-dimethylorsellinic acid-based meroterpenoid for the treatment of Alzheimer's disease.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30430177</pmid><doi>10.1039/c8ob02741b</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8881-1232</orcidid><orcidid>https://orcid.org/0000-0002-6672-0014</orcidid><orcidid>https://orcid.org/0000-0001-9133-6439</orcidid><orcidid>https://orcid.org/0000-0003-4272-9003</orcidid><orcidid>https://orcid.org/0000-0002-7222-2142</orcidid><orcidid>https://orcid.org/0000-0002-1247-5615</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1477-0520 |
ispartof | Organic & biomolecular chemistry, 2018-11, Vol.16 (46), p.9046-9052 |
issn | 1477-0520 1477-0539 |
language | eng |
recordid | cdi_proquest_miscellaneous_2133825789 |
source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
subjects | Acetylcholinesterase Acetylcholinesterase - metabolism Acids Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Amyloid precursor protein Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Aspartic Acid Endopeptidases - antagonists & inhibitors Aspartic Acid Endopeptidases - metabolism Aspergillus - chemistry Aspergillus terreus Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Crystallography Crystallography, X-Ray GPI-Linked Proteins - antagonists & inhibitors GPI-Linked Proteins - metabolism Humans Medical treatment Models, Molecular Molecular Docking Simulation Neurodegenerative diseases NMR Nuclear magnetic resonance Organic chemistry Proteins Resorcinols - chemical synthesis Resorcinols - chemistry Resorcinols - pharmacology Single crystals Tetrahydrofuran X ray spectra X-ray diffraction β-Site APP-cleaving enzyme 1 |
title | New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T10%3A17%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%203,5-dimethylorsellinic%20acid-based%20meroterpenoids%20with%20BACE1%20and%20AchE%20inhibitory%20activities%20from%20Aspergillus%20terreus&rft.jtitle=Organic%20&%20biomolecular%20chemistry&rft.au=Qi,%20Changxing&rft.date=2018-11-28&rft.volume=16&rft.issue=46&rft.spage=9046&rft.epage=9052&rft.pages=9046-9052&rft.issn=1477-0520&rft.eissn=1477-0539&rft_id=info:doi/10.1039/c8ob02741b&rft_dat=%3Cproquest_cross%3E2138873494%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2138873494&rft_id=info:pmid/30430177&rfr_iscdi=true |