Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature

Deuteration of the exchangeable hydrogens of [ N ]urea was found to prolong the T of the N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [ N ]urea, compared to [ C]urea - a pre-clinically proven perfusion agent, makes...

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Veröffentlicht in:Chemphyschem 2018-09, Vol.19 (17), p.2148-2152
Hauptverfasser: Harris, Talia, Gamliel, Ayelet, Uppala, Sivaranjan, Nardi-Schreiber, Atara, Sosna, Jacob, Gomori, J Moshe, Katz-Brull, Rachel
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Sprache:eng
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Zusammenfassung:Deuteration of the exchangeable hydrogens of [ N ]urea was found to prolong the T of the N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [ N ]urea, compared to [ C]urea - a pre-clinically proven perfusion agent, makes [ N ]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing N sites bound to labile protons and determining the hyperpolarized N T in H O and D O. Dissolution in D O led to marked prolongation for all of the selected sites. In whole human blood, the T of [ N ]urea was shortened. We present a general strategy for exploiting the markedly longer T outside the body and the quick decay in blood for performing multiple hyperpolarized perfusion measurements with a single hyperpolarized dose. Improved storage of the generated [ N ]urea polarization prior to the contact with the blood is demonstrated using higher temperatures due to further T prolongation.
ISSN:1439-4235
1439-7641
DOI:10.1002/cphc.201800261