Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature
Deuteration of the exchangeable hydrogens of [ N ]urea was found to prolong the T of the N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [ N ]urea, compared to [ C]urea - a pre-clinically proven perfusion agent, makes...
Gespeichert in:
Veröffentlicht in: | Chemphyschem 2018-09, Vol.19 (17), p.2148-2152 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Deuteration of the exchangeable hydrogens of [
N
]urea was found to prolong the T
of the
N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [
N
]urea, compared to [
C]urea - a pre-clinically proven perfusion agent, makes [
N
]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing
N sites bound to labile protons and determining the hyperpolarized
N T
in H
O and D
O. Dissolution in D
O led to marked prolongation for all of the selected sites. In whole human blood, the T
of [
N
]urea was shortened. We present a general strategy for exploiting the markedly longer T
outside the body and the quick decay in blood for performing multiple hyperpolarized perfusion measurements with a single hyperpolarized dose. Improved storage of the generated [
N
]urea polarization prior to the contact with the blood is demonstrated using higher temperatures due to further T
prolongation. |
---|---|
ISSN: | 1439-4235 1439-7641 |
DOI: | 10.1002/cphc.201800261 |