Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature
Deuteration of the exchangeable hydrogens of [ N ]urea was found to prolong the T of the N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [ N ]urea, compared to [ C]urea - a pre-clinically proven perfusion agent, makes...
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| Veröffentlicht in: | Chemphyschem 2018-09, Vol.19 (17), p.2148-2152 |
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| container_title | Chemphyschem |
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| creator | Harris, Talia Gamliel, Ayelet Uppala, Sivaranjan Nardi-Schreiber, Atara Sosna, Jacob Gomori, J Moshe Katz-Brull, Rachel |
| description | Deuteration of the exchangeable hydrogens of [
N
]urea was found to prolong the T
of the
N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [
N
]urea, compared to [
C]urea - a pre-clinically proven perfusion agent, makes [
N
]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing
N sites bound to labile protons and determining the hyperpolarized
N T
in H
O and D
O. Dissolution in D
O led to marked prolongation for all of the selected sites. In whole human blood, the T
of [
N
]urea was shortened. We present a general strategy for exploiting the markedly longer T
outside the body and the quick decay in blood for performing multiple hyperpolarized perfusion measurements with a single hyperpolarized dose. Improved storage of the generated [
N
]urea polarization prior to the contact with the blood is demonstrated using higher temperatures due to further T
prolongation. |
| doi_str_mv | 10.1002/cphc.201800261 |
| format | Article |
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N
]urea was found to prolong the T
of the
N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [
N
]urea, compared to [
C]urea - a pre-clinically proven perfusion agent, makes [
N
]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing
N sites bound to labile protons and determining the hyperpolarized
N T
in H
O and D
O. Dissolution in D
O led to marked prolongation for all of the selected sites. In whole human blood, the T
of [
N
]urea was shortened. We present a general strategy for exploiting the markedly longer T
outside the body and the quick decay in blood for performing multiple hyperpolarized perfusion measurements with a single hyperpolarized dose. Improved storage of the generated [
N
]urea polarization prior to the contact with the blood is demonstrated using higher temperatures due to further T
prolongation.</description><identifier>ISSN: 1439-4235</identifier><identifier>EISSN: 1439-7641</identifier><identifier>DOI: 10.1002/cphc.201800261</identifier><identifier>PMID: 29679471</identifier><language>eng</language><publisher>Germany</publisher><subject>Deuterium - chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Nitrogen Isotopes - chemistry ; Perfusion Imaging - methods ; Temperature ; Urea - blood ; Urea - chemistry</subject><ispartof>Chemphyschem, 2018-09, Vol.19 (17), p.2148-2152</ispartof><rights>2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1401-bb553bd5ef0a63395f4008d51f4bf77420e35467f72e5f9483b284c58a03f75b3</citedby><cites>FETCH-LOGICAL-c1401-bb553bd5ef0a63395f4008d51f4bf77420e35467f72e5f9483b284c58a03f75b3</cites><orcidid>0000-0003-4850-1616</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29679471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, Talia</creatorcontrib><creatorcontrib>Gamliel, Ayelet</creatorcontrib><creatorcontrib>Uppala, Sivaranjan</creatorcontrib><creatorcontrib>Nardi-Schreiber, Atara</creatorcontrib><creatorcontrib>Sosna, Jacob</creatorcontrib><creatorcontrib>Gomori, J Moshe</creatorcontrib><creatorcontrib>Katz-Brull, Rachel</creatorcontrib><title>Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature</title><title>Chemphyschem</title><addtitle>Chemphyschem</addtitle><description>Deuteration of the exchangeable hydrogens of [
N
]urea was found to prolong the T
of the
N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [
N
]urea, compared to [
C]urea - a pre-clinically proven perfusion agent, makes [
N
]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing
N sites bound to labile protons and determining the hyperpolarized
N T
in H
O and D
O. Dissolution in D
O led to marked prolongation for all of the selected sites. In whole human blood, the T
of [
N
]urea was shortened. We present a general strategy for exploiting the markedly longer T
outside the body and the quick decay in blood for performing multiple hyperpolarized perfusion measurements with a single hyperpolarized dose. Improved storage of the generated [
N
]urea polarization prior to the contact with the blood is demonstrated using higher temperatures due to further T
prolongation.</description><subject>Deuterium - chemistry</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Nitrogen Isotopes - chemistry</subject><subject>Perfusion Imaging - methods</subject><subject>Temperature</subject><subject>Urea - blood</subject><subject>Urea - chemistry</subject><issn>1439-4235</issn><issn>1439-7641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1P20AQhldVqwJprz2iPXJx2E-vfWxDIEgpRBU9W2N7NizYXrNrV4X_0_-JI0J6mS89845GLyHfOJtzxsR51d9Xc8F4NjUp_0COuZJ5YlLFP-5rJaQ-IicxPjDGMmb4Z3Ik8tTkyvBj8m_tu23SuD9YU67pDV099xh630BwLzA431HoavoLejdFbODvfhgp0I0fsBscNPQHRBep9WFieoRhUrt0IQ50AzHSDQY7xt3adQtb121pQn9CeJyopbVYDZF6Sy9wHDD8v3mHbb_rx4BfyCcLTcSv-zwjvy-Xd4tVsr69ul58XycVV4wnZam1LGuNlkEqZa6tml6uNbeqtMYowVBqlRprBGqbq0yWIlOVzoBJa3QpZ-TsTbcP_mnEOBStixU2DXTox1gIJrJcc6bZhM7f0Cr4GAPaog-uhfBccFbsrCl21hQHa6aF0732WLZYH_B3L-QrP_eKxg</recordid><startdate>20180905</startdate><enddate>20180905</enddate><creator>Harris, Talia</creator><creator>Gamliel, Ayelet</creator><creator>Uppala, Sivaranjan</creator><creator>Nardi-Schreiber, Atara</creator><creator>Sosna, Jacob</creator><creator>Gomori, J Moshe</creator><creator>Katz-Brull, Rachel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4850-1616</orcidid></search><sort><creationdate>20180905</creationdate><title>Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature</title><author>Harris, Talia ; Gamliel, Ayelet ; Uppala, Sivaranjan ; Nardi-Schreiber, Atara ; Sosna, Jacob ; Gomori, J Moshe ; Katz-Brull, Rachel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1401-bb553bd5ef0a63395f4008d51f4bf77420e35467f72e5f9483b284c58a03f75b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Deuterium - chemistry</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Nitrogen Isotopes - chemistry</topic><topic>Perfusion Imaging - methods</topic><topic>Temperature</topic><topic>Urea - blood</topic><topic>Urea - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harris, Talia</creatorcontrib><creatorcontrib>Gamliel, Ayelet</creatorcontrib><creatorcontrib>Uppala, Sivaranjan</creatorcontrib><creatorcontrib>Nardi-Schreiber, Atara</creatorcontrib><creatorcontrib>Sosna, Jacob</creatorcontrib><creatorcontrib>Gomori, J Moshe</creatorcontrib><creatorcontrib>Katz-Brull, Rachel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemphyschem</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harris, Talia</au><au>Gamliel, Ayelet</au><au>Uppala, Sivaranjan</au><au>Nardi-Schreiber, Atara</au><au>Sosna, Jacob</au><au>Gomori, J Moshe</au><au>Katz-Brull, Rachel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature</atitle><jtitle>Chemphyschem</jtitle><addtitle>Chemphyschem</addtitle><date>2018-09-05</date><risdate>2018</risdate><volume>19</volume><issue>17</issue><spage>2148</spage><epage>2152</epage><pages>2148-2152</pages><issn>1439-4235</issn><eissn>1439-7641</eissn><abstract>Deuteration of the exchangeable hydrogens of [
N
]urea was found to prolong the T
of the
N sites to more than 3 min at physiological temperatures. This significant increase in the lifetime of the hyperpolarized state of [
N
]urea, compared to [
C]urea - a pre-clinically proven perfusion agent, makes [
N
]urea a promising perfusion agent. The molecular parameters that may lead to this profound effect were assessed by investigating small molecules with different molecular structures containing
N sites bound to labile protons and determining the hyperpolarized
N T
in H
O and D
O. Dissolution in D
O led to marked prolongation for all of the selected sites. In whole human blood, the T
of [
N
]urea was shortened. We present a general strategy for exploiting the markedly longer T
outside the body and the quick decay in blood for performing multiple hyperpolarized perfusion measurements with a single hyperpolarized dose. Improved storage of the generated [
N
]urea polarization prior to the contact with the blood is demonstrated using higher temperatures due to further T
prolongation.</abstract><cop>Germany</cop><pmid>29679471</pmid><doi>10.1002/cphc.201800261</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4850-1616</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Chemphyschem, 2018-09, Vol.19 (17), p.2148-2152 |
| issn | 1439-4235 1439-7641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2028951050 |
| source | MEDLINE; Wiley Journals |
| subjects | Deuterium - chemistry Humans Magnetic Resonance Spectroscopy Nitrogen Isotopes - chemistry Perfusion Imaging - methods Temperature Urea - blood Urea - chemistry |
| title | Long-lived 15 N Hyperpolarization and Rapid Relaxation as a Potential Basis for Repeated First Pass Perfusion Imaging - Marked Effects of Deuteration and Temperature |
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