Age-related changes in the mitochondria of human mural granulosa cells

What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. Mitochondria play an imp...

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Veröffentlicht in:Human reproduction (Oxford) 2017-12, Vol.32 (12), p.2465-2473
Hauptverfasser: Liu, Yifan, Han, Ming, Li, Xiaoshuang, Wang, Hui, Ma, Minyue, Zhang, Shihui, Guo, Yifan, Wang, Shuling, Wang, Yuanfen, Duan, Na, Xu, Bing, Yin, Jingwen, Yao, Yuanqing
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Sprache:eng
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Zusammenfassung:What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. Mitochondria play an important role in the dialogue between the mGCs and oocytes. However, the underlying mechanism of mitochondrial dysfunction in mGCs in aging is still poorly understood. In total, 149 infertile women underwent IVF in the ART Centre of the Chinese PLA General Hospital, China from September 2016 to May 2017. Two age groups were investigated: the young group (
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/dex309