Age-related changes in the mitochondria of human mural granulosa cells

What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. Mitochondria play an imp...

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Veröffentlicht in:	Human reproduction (Oxford) 2017-12, Vol.32 (12), p.2465-2473
Hauptverfasser:	Liu, Yifan, Han, Ming, Li, Xiaoshuang, Wang, Hui, Ma, Minyue, Zhang, Shihui, Guo, Yifan, Wang, Shuling, Wang, Yuanfen, Duan, Na, Xu, Bing, Yin, Jingwen, Yao, Yuanqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adult Age Factors DNA, Mitochondrial - genetics Fallopian Tubes - pathology Female Fertilization in Vitro Granulosa Cells - cytology Granulosa Cells - pathology Humans Infertility, Female Membrane Potentials Mitochondria - metabolism Mitochondrial Membranes - metabolism Mitochondrial Proton-Translocating ATPases - metabolism Oocytes - cytology Oxidative Phosphorylation Reactive Oxygen Species - metabolism
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