Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES

Background The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan. Methods This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mea...

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Veröffentlicht in:Pediatric diabetes 2016-09, Vol.17 (6), p.407-416
Hauptverfasser: Wang, Nan-Kai, Lai, Chi-Chun, Wang, Jung-Pan, Wu, Wei-Chi, Liu, Laura, Yeh, Lung-Kun, Tseng, Hsiao-Jung, Chang, Chee-Jen, Lo, Fu-Sung
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Sprache:eng
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Zusammenfassung:Background The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan. Methods This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self‐reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball. Results There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional‐hazards analysis showed that older‐onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration. Conclusions Development of retinopathy 10 yr after diagnosis in people with juvenile‐onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.
ISSN:1399-543X
1399-5448
DOI:10.1111/pedi.12312