Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES
Background The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan. Methods This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mea...
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| Veröffentlicht in: | Pediatric diabetes 2016-09, Vol.17 (6), p.407-416 |
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| container_title | Pediatric diabetes |
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| creator | Wang, Nan-Kai Lai, Chi-Chun Wang, Jung-Pan Wu, Wei-Chi Liu, Laura Yeh, Lung-Kun Tseng, Hsiao-Jung Chang, Chee-Jen Lo, Fu-Sung |
| description | Background
The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan.
Methods
This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self‐reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball.
Results
There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional‐hazards analysis showed that older‐onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration.
Conclusions
Development of retinopathy 10 yr after diagnosis in people with juvenile‐onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration. |
| doi_str_mv | 10.1111/pedi.12312 |
| format | Article |
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The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan.
Methods
This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self‐reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball.
Results
There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional‐hazards analysis showed that older‐onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration.
Conclusions
Development of retinopathy 10 yr after diagnosis in people with juvenile‐onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/pedi.12312</identifier><identifier>PMID: 26332951</identifier><language>eng</language><publisher>Former Munksgaard: John Wiley & Sons A/S</publisher><subject>Adolescent ; Adult ; Diabetes Mellitus, Type 1 - complications ; diabetic retinopathy ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - etiology ; Follow-Up Studies ; Humans ; juvenile onset ; Risk Factors ; T1DM ; Taiwan - epidemiology ; Young Adult</subject><ispartof>Pediatric diabetes, 2016-09, Vol.17 (6), p.407-416</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-6055f85ef453b3927470ad6b75162614f6f43151d71d95bda5e8ce7db42390073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpedi.12312$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpedi.12312$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26332951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Nan-Kai</creatorcontrib><creatorcontrib>Lai, Chi-Chun</creatorcontrib><creatorcontrib>Wang, Jung-Pan</creatorcontrib><creatorcontrib>Wu, Wei-Chi</creatorcontrib><creatorcontrib>Liu, Laura</creatorcontrib><creatorcontrib>Yeh, Lung-Kun</creatorcontrib><creatorcontrib>Tseng, Hsiao-Jung</creatorcontrib><creatorcontrib>Chang, Chee-Jen</creatorcontrib><creatorcontrib>Lo, Fu-Sung</creatorcontrib><creatorcontrib>Chang Gung Juvenile Diabetes Eye Study Group</creatorcontrib><title>Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>Background
The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan.
Methods
This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self‐reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball.
Results
There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional‐hazards analysis showed that older‐onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration.
Conclusions
Development of retinopathy 10 yr after diagnosis in people with juvenile‐onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>diabetic retinopathy</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Diabetic Retinopathy - etiology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>juvenile onset</subject><subject>Risk Factors</subject><subject>T1DM</subject><subject>Taiwan - epidemiology</subject><subject>Young Adult</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1u1DAUhS0EoqWw4QGQl2zS-id2JuzQzDAUVfwW0Z3lxNeM2yRObadDdt3yHLwZT0Jmpszd3Cvd75zFOQi9pOSUTnPWg3GnlHHKHqFjyssyE3k-e3y4-dURehbjNSG0KHn-FB0xyTkrBT1Gf766eIOtrpMPEesYfe10AoM3Lq1xWgM2cAeN71voEvYWB0iu871O6xFT8vf-9xiwtgnCHnb6Z-eji1v0eriDzjWQ-S5CwmnsAdMtUkGCiF2HL7Xb6O4N1rj2ax8SjmkwI7bBtzu7-erDYvntOXpidRPhxcM-Qd_fLS_n77OLT6vz-duLrOaCs0wSIexMgM0Fr3jJirwg2siqEFQySXMrbc6poKagphSV0QJmNRSmyhkvCSn4CXq99-2Dvx0gJtW6WEPT6A78EBWdkVISyaic0FcP6FC1YFQfXKvDqP4HOwF0D2ymAMbDnxK1rUxtK1O7ytTn5eJ8d02abK9xMcGvg0aHGyULXgj14-NKkfmXq0W5yBXh_wD8K5nM</recordid><startdate>201609</startdate><enddate>201609</enddate><creator>Wang, Nan-Kai</creator><creator>Lai, Chi-Chun</creator><creator>Wang, Jung-Pan</creator><creator>Wu, Wei-Chi</creator><creator>Liu, Laura</creator><creator>Yeh, Lung-Kun</creator><creator>Tseng, Hsiao-Jung</creator><creator>Chang, Chee-Jen</creator><creator>Lo, Fu-Sung</creator><general>John Wiley & Sons A/S</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201609</creationdate><title>Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES</title><author>Wang, Nan-Kai ; Lai, Chi-Chun ; Wang, Jung-Pan ; Wu, Wei-Chi ; Liu, Laura ; Yeh, Lung-Kun ; Tseng, Hsiao-Jung ; Chang, Chee-Jen ; Lo, Fu-Sung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-6055f85ef453b3927470ad6b75162614f6f43151d71d95bda5e8ce7db42390073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>diabetic retinopathy</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Diabetic Retinopathy - etiology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>juvenile onset</topic><topic>Risk Factors</topic><topic>T1DM</topic><topic>Taiwan - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Nan-Kai</creatorcontrib><creatorcontrib>Lai, Chi-Chun</creatorcontrib><creatorcontrib>Wang, Jung-Pan</creatorcontrib><creatorcontrib>Wu, Wei-Chi</creatorcontrib><creatorcontrib>Liu, Laura</creatorcontrib><creatorcontrib>Yeh, Lung-Kun</creatorcontrib><creatorcontrib>Tseng, Hsiao-Jung</creatorcontrib><creatorcontrib>Chang, Chee-Jen</creatorcontrib><creatorcontrib>Lo, Fu-Sung</creatorcontrib><creatorcontrib>Chang Gung Juvenile Diabetes Eye Study Group</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Nan-Kai</au><au>Lai, Chi-Chun</au><au>Wang, Jung-Pan</au><au>Wu, Wei-Chi</au><au>Liu, Laura</au><au>Yeh, Lung-Kun</au><au>Tseng, Hsiao-Jung</au><au>Chang, Chee-Jen</au><au>Lo, Fu-Sung</au><aucorp>Chang Gung Juvenile Diabetes Eye Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2016-09</date><risdate>2016</risdate><volume>17</volume><issue>6</issue><spage>407</spage><epage>416</epage><pages>407-416</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>Background
The aim of this study was to examine risk factors associated with the development of diabetic retinopathy (DR) 10 yr after the diagnosis of juvenile‐onset type 1 diabetes in Taiwan.
Methods
This retrospective cohort study of 153 individuals with type 1 diabetes for >10 yr duration (mean duration: 13.1 yr) included participants in the Chang Gung Juvenile Diabetes Eye Study. Risk factors assessed for association with DR included age, gender, age at onset and duration of diabetes, self‐reported smoking, blood pressure, lipid profile, urinalysis, glycated hemoglobin (HbA1c), body mass index, spherical equivalent, and axial length of the eyeball.
Results
There were 128 patients without DR and 25 patients with DR. The mean age at onset was 7.0 ± 4.0 yr (mean ± standard deviation). Cox proportional‐hazards analysis showed that older‐onset age (p = 0.001), higher HbA1c (p = 0.013), and higher triglyceride concentration (p = 0.015) were the strongest correlates of DR after adjustment for diabetes duration.
Conclusions
Development of retinopathy 10 yr after diagnosis in people with juvenile‐onset type 1 diabetes was associated with older onset age, higher HbA1c, and higher triglyceride concentration.</abstract><cop>Former Munksgaard</cop><pub>John Wiley & Sons A/S</pub><pmid>26332951</pmid><doi>10.1111/pedi.12312</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Pediatric diabetes, 2016-09, Vol.17 (6), p.407-416 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Diabetes Mellitus, Type 1 - complications diabetic retinopathy Diabetic Retinopathy - epidemiology Diabetic Retinopathy - etiology Follow-Up Studies Humans juvenile onset Risk Factors T1DM Taiwan - epidemiology Young Adult |
| title | Risk factors associated with the development of retinopathy 10 yr after the diagnosis of juvenile-onset type 1 diabetes in Taiwan: a cohort study from the CGJDES |
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