A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

A concise synthetic approach toward tamiflu (oseltamivir phosphate): cis-aziridine as the key synthon and RCM

The key synthon cis -aziridine has been efficiently utilised for the synthesis of oseltamivir phosphate, using Wittig olefination, Barbier addition, Mitsunobu reaction and ring closing metathesis (RCM) as key essentials.

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Bibliographische Detailangaben
Veröffentlicht in:RSC advances 2014-01, Vol.4 (22), p.11417-11419
Hauptverfasser: Chavan, Subhash P., Chavan, Prakash N., Khairnar, Lalit B.
Format: Artikel
Sprache:eng
Schlagworte:
Decomposition reactions
Metathesis
Phosphates
RCM
Synthesis
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Zusammenfassung:The key synthon cis -aziridine has been efficiently utilised for the synthesis of oseltamivir phosphate, using Wittig olefination, Barbier addition, Mitsunobu reaction and ring closing metathesis (RCM) as key essentials.
ISSN:2046-2069
2046-2069
DOI:10.1039/C3RA47210H