The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes
The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and con...
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Veröffentlicht in: | In vitro cellular & developmental biology. Animal 1994-03, Vol.30A (3), p.187-191 |
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container_title | In vitro cellular & developmental biology. Animal |
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creator | HANAFIN, N. M PERSONS, K. S HOLICK, M. F |
description | The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes. |
doi_str_mv | 10.1007/BF02631442 |
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Psychology ; Gene expression ; Gene Expression - drug effects ; Genes, myc - genetics ; Genetic engineering ; Genetic technics ; Humans ; Keratinocytes - cytology ; Keratinocytes - drug effects ; Keratinocytes - physiology ; Methods. Procedures. Technologies ; Miscellaneous ; Molecular and cellular biology ; Molecular genetics ; Receptors, Calcitriol - genetics ; RNA, Messenger ; Synthetic digonucleotides and genes. Sequencing</subject><ispartof>In vitro cellular & developmental biology. 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F</creatorcontrib><title>The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes.</description><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Calcitriol - pharmacology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Genes, myc - genetics</subject><subject>Genetic engineering</subject><subject>Genetic technics</subject><subject>Humans</subject><subject>Keratinocytes - cytology</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - physiology</subject><subject>Methods. Procedures. Technologies</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Receptors, Calcitriol - genetics</subject><subject>RNA, Messenger</subject><subject>Synthetic digonucleotides and genes. 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F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c229t-2cb2139037257683020b11c45f0ea82e57e299c45913537164b623104efa922e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Calcitriol - pharmacology</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Genes, myc - genetics</topic><topic>Genetic engineering</topic><topic>Genetic technics</topic><topic>Humans</topic><topic>Keratinocytes - cytology</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - physiology</topic><topic>Methods. Procedures. Technologies</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Receptors, Calcitriol - genetics</topic><topic>RNA, Messenger</topic><topic>Synthetic digonucleotides and genes. Sequencing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HANAFIN, N. M</creatorcontrib><creatorcontrib>PERSONS, K. S</creatorcontrib><creatorcontrib>HOLICK, M. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>In vitro cellular & developmental biology. Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HANAFIN, N. M</au><au>PERSONS, K. S</au><au>HOLICK, M. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>1994-03</date><risdate>1994</risdate><volume>30A</volume><issue>3</issue><spage>187</spage><epage>191</epage><pages>187-191</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><abstract>The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes.</abstract><cop>Largo, MD</cop><pub>Society for In Vitro Biology</pub><pmid>25939167</pmid><doi>10.1007/BF02631442</doi><tpages>5</tpages></addata></record> |
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subjects | Biological and medical sciences Biotechnology Calcitriol - pharmacology Cell Proliferation - drug effects Cells, Cultured Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Genes, myc - genetics Genetic engineering Genetic technics Humans Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - physiology Methods. Procedures. Technologies Miscellaneous Molecular and cellular biology Molecular genetics Receptors, Calcitriol - genetics RNA, Messenger Synthetic digonucleotides and genes. Sequencing |
title | The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes |
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