The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes

The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and con...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 1994-03, Vol.30A (3), p.187-191
Hauptverfasser:	HANAFIN, N. M, PERSONS, K. S, HOLICK, M. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Calcitriol - pharmacology Cell Proliferation - drug effects Cells, Cultured Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gene expression Gene Expression - drug effects Genes, myc - genetics Genetic engineering Genetic technics Humans Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - physiology Methods. Procedures. Technologies Miscellaneous Molecular and cellular biology Molecular genetics Receptors, Calcitriol - genetics RNA, Messenger Synthetic digonucleotides and genes. Sequencing
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Zusammenfassung:	The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes.
ISSN:	1071-2690 1543-706X
DOI:	10.1007/BF02631442