Imbalance of circulating lymphoid cells in Q fever endocarditis

Q fever endocarditis is characterized by a defective cell-mediated immune response, which may be associated with the dysregulation of circulating subsets of immune cells. In this study, we found that naïve CD8+ T lymphocytes and CD56dim natural killer cells were decreased patients whereas central me...

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Veröffentlicht in:Pathogens and disease 2015-03, Vol.73 (2), p.1-3
Hauptverfasser: Ka, Mignane B., Gondois-Rey, Françoise, Ghigo, Eric, Raoult, Didier, Olive, Daniel, Mege, Jean-Louis
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Sprache:eng
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Zusammenfassung:Q fever endocarditis is characterized by a defective cell-mediated immune response, which may be associated with the dysregulation of circulating subsets of immune cells. In this study, we found that naïve CD8+ T lymphocytes and CD56dim natural killer cells were decreased patients whereas central memory CD8+ T lymphocytes were increased. It is likely that these different subsets of immune cells play a role in the immunosuppression accompanying Q fever endocarditis.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/ftu010