Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord
•TRPV1 and TRPV2 channels are multimodal sensors.•Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2.•Sympathetic neurons were surrounded by TRPV2-containing nerve fibers.•Lateral horn neurons in human spinal cord have TRPV2.•There is TRPV1- or TRPV2-containing sympathetic path...
Gespeichert in:
Veröffentlicht in: | Neuroscience letters 2015-03, Vol.590, p.6-11 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | •TRPV1 and TRPV2 channels are multimodal sensors.•Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2.•Sympathetic neurons were surrounded by TRPV2-containing nerve fibers.•Lateral horn neurons in human spinal cord have TRPV2.•There is TRPV1- or TRPV2-containing sympathetic pathway in stellate ganglion and spinal cord.
Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600μm2) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small ( |
---|---|
ISSN: | 0304-3940 1872-7972 |
DOI: | 10.1016/j.neulet.2015.01.074 |