Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord
•TRPV1 and TRPV2 channels are multimodal sensors.•Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2.•Sympathetic neurons were surrounded by TRPV2-containing nerve fibers.•Lateral horn neurons in human spinal cord have TRPV2.•There is TRPV1- or TRPV2-containing sympathetic path...
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| Veröffentlicht in: | Neuroscience letters 2015-03, Vol.590, p.6-11 |
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| creator | Kokubun, Souichi Sato, Tadasu Ogawa, Chikara Kudo, Kai Goto, Koju Fujii, Yuki Shimizu, Yoshinaka Ichikawa, Hiroyuki |
| description | •TRPV1 and TRPV2 channels are multimodal sensors.•Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2.•Sympathetic neurons were surrounded by TRPV2-containing nerve fibers.•Lateral horn neurons in human spinal cord have TRPV2.•There is TRPV1- or TRPV2-containing sympathetic pathway in stellate ganglion and spinal cord.
Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600μm2) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small ( |
| doi_str_mv | 10.1016/j.neulet.2015.01.074 |
| format | Article |
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Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600μm2) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small (<600μm2) sympathetic neurons (TRPV1, 22.0%; TRPV2, 13.6%). The present study also demonstrated that 10.0% of sympathetic neurons in the stellate ganglion had pericellular TRPV2-IR nerve fibers. Fourteen percent of large neurons and 7.8% of small neurons were surrounded by TRPV2-IR nerve fibers. TRPV2-immunoreactivity was also detected in about 40% of neuronal cell bodies with pericellular TRPV2-IR nerve fibers. In the lateral horn of the human thoracic spinal cord, TRPV2-immunoreactivity was expressed by some neurons and many varicose fibers surrounding TRPV2-immunonegative neurons. TRPV2-IR pericellular fibers in the stellate ganglion may originate from the lateral horn of the spinal cord. There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2015.01.074</identifier><identifier>PMID: 25641129</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Aged ; Aged, 80 and over ; Cell Size ; Female ; Human ; Humans ; Immunohistochemistry ; Male ; Nerve Fibers - metabolism ; Neurons - cytology ; Neurons - metabolism ; Organ Specificity ; Spinal cord ; Spinal Cord - metabolism ; Stellate ganglion ; Stellate Ganglion - metabolism ; TRPV Cation Channels - metabolism ; TRPV1 ; TRPV2</subject><ispartof>Neuroscience letters, 2015-03, Vol.590, p.6-11</ispartof><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-df94b44e269978392d6b3fb799f1f0cc2b645271ac908850778a48bdeb3f520a3</citedby><cites>FETCH-LOGICAL-c479t-df94b44e269978392d6b3fb799f1f0cc2b645271ac908850778a48bdeb3f520a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394015000877$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25641129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kokubun, Souichi</creatorcontrib><creatorcontrib>Sato, Tadasu</creatorcontrib><creatorcontrib>Ogawa, Chikara</creatorcontrib><creatorcontrib>Kudo, Kai</creatorcontrib><creatorcontrib>Goto, Koju</creatorcontrib><creatorcontrib>Fujii, Yuki</creatorcontrib><creatorcontrib>Shimizu, Yoshinaka</creatorcontrib><creatorcontrib>Ichikawa, Hiroyuki</creatorcontrib><title>Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•TRPV1 and TRPV2 channels are multimodal sensors.•Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2.•Sympathetic neurons were surrounded by TRPV2-containing nerve fibers.•Lateral horn neurons in human spinal cord have TRPV2.•There is TRPV1- or TRPV2-containing sympathetic pathway in stellate ganglion and spinal cord.
Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600μm2) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small (<600μm2) sympathetic neurons (TRPV1, 22.0%; TRPV2, 13.6%). The present study also demonstrated that 10.0% of sympathetic neurons in the stellate ganglion had pericellular TRPV2-IR nerve fibers. Fourteen percent of large neurons and 7.8% of small neurons were surrounded by TRPV2-IR nerve fibers. TRPV2-immunoreactivity was also detected in about 40% of neuronal cell bodies with pericellular TRPV2-IR nerve fibers. In the lateral horn of the human thoracic spinal cord, TRPV2-immunoreactivity was expressed by some neurons and many varicose fibers surrounding TRPV2-immunonegative neurons. TRPV2-IR pericellular fibers in the stellate ganglion may originate from the lateral horn of the spinal cord. There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cell Size</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Nerve Fibers - metabolism</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Organ Specificity</subject><subject>Spinal cord</subject><subject>Spinal Cord - metabolism</subject><subject>Stellate ganglion</subject><subject>Stellate Ganglion - metabolism</subject><subject>TRPV Cation Channels - metabolism</subject><subject>TRPV1</subject><subject>TRPV2</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1ExS7Qf4CQj1ySjh0nji9IaKGlEmortO3VcpwJeJV1FttB6r9v0kCPPc0cnnc-HkIuGOQMWPVpl3sce0w5B1bmwHKQ4oisWS15JpXkx2QNBYisUAJW5DTGHQCUrBQnZMXLSjDG1Zp8u3UxBdeMyQ2eDh3dPv74xajx7d-OU-dpekb6PO6NpzFh35uE9Mn4p35OzGA8OG96aofQnpMPnekjfnyrZ-Tn57vt5j57-P7l6-bmIbNCqpS1nRKNEMgrpWRdKN5WTdE1UqmOdWAtbypRcsmMVVDXJUhZG1E3LU5UycEUZ-RqmXsIw8uIMem9i3Y-zuMwRs2qCkQhJZcTKhbUhiHGgJ0-BLc34bdmoGeTeqcXk3o2qYHpyeQUu3zbMDZ7bP-F3tVNwPUC4PTnq8Ogo3XoLbYuoE26Hdz_N_wB3eeE4A</recordid><startdate>20150317</startdate><enddate>20150317</enddate><creator>Kokubun, Souichi</creator><creator>Sato, Tadasu</creator><creator>Ogawa, Chikara</creator><creator>Kudo, Kai</creator><creator>Goto, Koju</creator><creator>Fujii, Yuki</creator><creator>Shimizu, Yoshinaka</creator><creator>Ichikawa, Hiroyuki</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150317</creationdate><title>Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord</title><author>Kokubun, Souichi ; Sato, Tadasu ; Ogawa, Chikara ; Kudo, Kai ; Goto, Koju ; Fujii, Yuki ; Shimizu, Yoshinaka ; Ichikawa, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-df94b44e269978392d6b3fb799f1f0cc2b645271ac908850778a48bdeb3f520a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cell Size</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Nerve Fibers - metabolism</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Organ Specificity</topic><topic>Spinal cord</topic><topic>Spinal Cord - metabolism</topic><topic>Stellate ganglion</topic><topic>Stellate Ganglion - metabolism</topic><topic>TRPV Cation Channels - metabolism</topic><topic>TRPV1</topic><topic>TRPV2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kokubun, Souichi</creatorcontrib><creatorcontrib>Sato, Tadasu</creatorcontrib><creatorcontrib>Ogawa, Chikara</creatorcontrib><creatorcontrib>Kudo, Kai</creatorcontrib><creatorcontrib>Goto, Koju</creatorcontrib><creatorcontrib>Fujii, Yuki</creatorcontrib><creatorcontrib>Shimizu, Yoshinaka</creatorcontrib><creatorcontrib>Ichikawa, Hiroyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kokubun, Souichi</au><au>Sato, Tadasu</au><au>Ogawa, Chikara</au><au>Kudo, Kai</au><au>Goto, Koju</au><au>Fujii, Yuki</au><au>Shimizu, Yoshinaka</au><au>Ichikawa, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2015-03-17</date><risdate>2015</risdate><volume>590</volume><spage>6</spage><epage>11</epage><pages>6-11</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•TRPV1 and TRPV2 channels are multimodal sensors.•Sympathetic neurons in human stellate ganglion contained TRPV1 and TRPV2.•Sympathetic neurons were surrounded by TRPV2-containing nerve fibers.•Lateral horn neurons in human spinal cord have TRPV2.•There is TRPV1- or TRPV2-containing sympathetic pathway in stellate ganglion and spinal cord.
Immunohistochemistry for the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2) was performed on the stellate ganglion and spinal cord in human cadavers. In the stellate ganglion, 25.3% and 16.2% of sympathetic neurons contained TRPV1- and TRPV2-immunoreactivity, respectively. The cell size analysis also demonstrated that proportion of TRPV1- or TRPV2-immunoreactive (-IR) neurons among large (>600μm2) sympathetic neurons (TRPV1, 30.7%; TRPV2, 27.0%) was higher than among small (<600μm2) sympathetic neurons (TRPV1, 22.0%; TRPV2, 13.6%). The present study also demonstrated that 10.0% of sympathetic neurons in the stellate ganglion had pericellular TRPV2-IR nerve fibers. Fourteen percent of large neurons and 7.8% of small neurons were surrounded by TRPV2-IR nerve fibers. TRPV2-immunoreactivity was also detected in about 40% of neuronal cell bodies with pericellular TRPV2-IR nerve fibers. In the lateral horn of the human thoracic spinal cord, TRPV2-immunoreactivity was expressed by some neurons and many varicose fibers surrounding TRPV2-immunonegative neurons. TRPV2-IR pericellular fibers in the stellate ganglion may originate from the lateral horn of the spinal cord. There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25641129</pmid><doi>10.1016/j.neulet.2015.01.074</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Cell Size Female Human Humans Immunohistochemistry Male Nerve Fibers - metabolism Neurons - cytology Neurons - metabolism Organ Specificity Spinal cord Spinal Cord - metabolism Stellate ganglion Stellate Ganglion - metabolism TRPV Cation Channels - metabolism TRPV1 TRPV2 |
| title | Distribution of TRPV1 and TRPV2 in the human stellate ganglion and spinal cord |
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